Cognitive function improving agent
Provided are a cognitive function improving agent effective for improving cognitive function such as memory and learning ability, and a method for evaluating or selecting the cognitive function improving agent. The cognitive function improving agent comprises a GIP function inhibitor as an active ingredient.
1. A method for improving cognitive function of a subject in need thereof, comprising administering a Glucose-Dependent Insulinotropic Polypeptide (GIP) function inhibitor to the subject, thereby improving the subject's cognitive function, wherein the cognitive function that is improved is the subject's memory and wherein the GIP function inhibitor is an anti-GIP antibody.
2. The method according to claim 1 , wherein the anti-GIP antibody is an anti-active GIP antibody.
3. The method of claim 2 , wherein the anti-active GIP antibody recognizes one or more amino acids selected from the 8th to 10th amino acids of the amino acid sequence of SEQ ID NO: 5, and wherein the antibody includes a region consisting of the amino acid sequence of the following formula (1) or a conservative sequence modification thereof in an H-chain: EMNPSDGRTHFNE (1).
4. The method of claim 3 , wherein the antibody includes a region consisting of the amino acid sequence of the following formula (1) in an H-chain:
EMNPSDGRTHFNE (1).
5. The method of claim 2 , wherein the amino acid sequence of the anti-active GIP antibody comprises a region consisting of the amino acid sequence of SEQ ID NO:2 or a conservative sequence modification thereof as an H-chain variable region.
6. The method of claim 5 , wherein the amino acid sequence of the anti-active GIP antibody comprises a region consisting of the amino acid sequence of SEQ ID NO: 2 as an H-chain variable region.
7. The method of claim 5 , wherein the conservatively modified amino acid sequence has a sequence identity of 90% or more with the amino acid sequence of SEQ ID NO: 2.
8. The method of claim 2 , wherein the anti-active GIP antibody comprises a region consisting of the amino acid sequence of SEQ ID NO:2 or a conservative sequence modification thereof as an H-chain variable region, and comprises a region consisting of the amino acid sequence of SEQ ID NO: 4 or a conservative sequence modification thereof as an L-chain variable region.
9. The method of claim 8 , wherein the amino acid sequence of the anti-active GIP antibody comprises the amino acid sequence of SEQ ID NO: 2 as an H-chain variable region and comprises the amino acid sequence of SEQ ID NO: 4 as an L-chain variable region.
10. The method of claim 8 , wherein the amino acid sequence of the region consisting of an amino acid sequence that is a conservative sequence modification of SEQ ID NO:2 has 90% or more sequence identity to SEQ ID NO:2 as an H-chain variable region and wherein the amino acid sequence of the region consisting of the amino acid sequence that is a conservative sequence modification of SEQ ID NO: 4 has 90% or more sequence identity to SEQ ID NO:4 as an L-chain variable region.
11. The method of claim 2 , wherein the subject is in need of improvement in the subject's short term memory.
12. The method of claim 2 , wherein the subject is in need of improvement in the subject's short-term memory.