Powdered collagen wound care compositions
Powdered collagen compositions and methods for wound care or the dressing or treatment of wounds in a subject in need thereof. The powdered collagen wound care composition includes powdered collagen or collagen-based material substantially covered with a hydrophobic barrier. In at least some instances, the hydrophobic barrier prevents the complete absorption or dissolution of the powdered collage or collagen-based material when placed on or in a wound or body of a subject for at least three (3) days. The powdered collagen wound care compositions are suitable for dressing or packing wounds or post-surgical incisions.
1. A collagen wound care composition, the composition comprising:
powdered collagen or powdered collagen-based material; and
a hydrophobic barrier, wherein the hydrophobic barrier at least partially coats the surface of the powdered collagen or powdered collagen-based material;
wherein the powdered collagen or powdered collagen-based material comprises from about 45 weight percent to about 85 weight percent of the collagen wound care composition; and
wherein the hydrophobic barrier comprises greater than about 80% by weight petrolatum.
2. The composition according to claim 1 , wherein the hydrophobic barrier is in the form of a coating at least partially surrounding and adsorbed to the powdered collagen or powdered collagen-based material, the coating effective to reduce the dissolution rate or the rate of absorption of the powdered collagen or powdered collagen-based material when placed in or on a wound in a subject in need thereof.
3. The composition according to claim 2 , wherein the hydrophobic barrier prevents the dissolution or absorption of the powdered collagen or powdered collagen-based material when placed on or in a wound or body of a subject for at least seven (7) days.
4. The composition according to claim 3 , wherein the wound and/or one or more tissues surrounding the wound is characterized as having a good blood supply.
5. The composition according to claim 1 , wherein the hydrophobic barrier comprises one or more oils selected from the group consisting of animal oil, vegetable oil, natural oil, synthetic oil, hydrocarbon oils, silicone oils, and semi-synthetic derivatives thereof, and any combination thereof.
6. The composition according to claim 1 , wherein the hydrophobic barrier comprises one or more preservatives selected from the group consisting of polyhexamethylene biguanide (PHMB), polyaminopropyl biguanide (PAPB), benzalkonium chloride, cetrimide, chlorhexidine, polihexanide biguanide, polihexanide, polyhexamethylene guanide, poly(iminoimidocarbonyl-iminoimidocarbonyl-iminohexamethylene), and any salt or combination thereof.
7. The composition according to claim 6 , wherein the hydrophobic barrier comprises from about 0.05% to about 5% by weight polyhexamethylene biguanide (PHMB) or polyaminopropyl biguanide (PAPB).
8. The composition according to claim 7 , wherein the hydrophobic barrier comprises one or more additional preservatives selected from the group consisting of benzalkonium chloride, cetrimide, chlorhexidine, and any salt or combination thereof.
9. The composition according to claim 7 , wherein the hydrophobic barrier comprises from about 0.001% to about 0.15% by weight benzalkonium chloride (BZK).
10. The composition according to claim 1 , wherein the hydrophobic barrier comprises from about 15 weight percent to about 55 weight percent of the collagen wound care composition.
11. The composition according to claim 1 , wherein the hydrophobic barrier comprises a polar solvent, the polar solvent comprising one or more preservatives and suspended in the hydrophobic barrier, wherein the polar solvent is selected from the group consisting of water, ethanol, a mixture of water and ethanol, acetic acid, and any combination thereof.
12. The composition according to claim 11 , wherein the hydrophobic barrier excludes an added emulsifier other than the recited components.
13. The composition according to claim 1 , wherein the powdered collagen or powdered collagen-based material is characterized by an average particle size of from about 5 microns to about 80 microns.
14. The composition according to claim 1 , wherein the collagen wound care composition has a fluffy or unconsolidated consistency suitable for wound packing.
15. A method of treating or dressing a wound or a post-surgical incision in a subject, the method comprising applying the composition according to claim 1 to a wound or post-surgical incision in need of dressing or treatment.
16. The method according to claim 15 , further comprising:
contacting the composition according to claim 1 to a wound covering, wherein the wound covering is a selected from the group consisting of a bandage, wrap, gauze, sponge, and film; and
applying the wound covering to the wound or post-surgical skin graft in need of treatment.
17. A method of packing a wound in need of dressing, the method comprising:
packing the wound with the composition according to claim 1 ; and
applying a wound covering to the packed wound.