Compositions and methods for treating neuropsychiatric disorders
As described below, the present invention features compositions and methods for treating brain and/or behavioral health disorders and their associated symptoms.
1. A therapeutic combination for the treatment of a panic disorder, social anxiety disorder, or post-traumatic stress disorder in a subject in need thereof, the therapeutic combination comprising an effective amount of verapamil and telmisartan for the treatment of a panic disorder, social anxiety disorder, or post-traumatic stress disorder, wherein the effective amount of verapamil is between about 120 mg and 360 mg and the effective amount of telmisartan is between about 40 mg and about 180 mg, and wherein the mass ratio of verapamil to telmisartan in the combination is between about 2:1 and about 3:1.
2. The therapeutic combination of claim 1 , wherein verapamil and telmisartan are formulated separately.
3. The therapeutic combination of claim 1 , wherein verapamil and telmisartan are formulated together.
4. The therapeutic combination of claim 1 , wherein verapamil and/or telmisartan is provided in an extended release formulation.
5. The therapeutic combination of claim 1 , wherein the mass ratio of verapamil to telmisartan is about 3:1.
6. A therapeutic combination for the treatment of a panic disorder, social anxiety disorder, or post-traumatic stress disorder in a subject in need thereof, the therapeutic combination comprising an effective amount of verapamil and telmisartan for the treatment of a panic disorder, social anxiety disorder, or post-traumatic stress disorder, wherein the effective amount of verapamil is between about 120 mg and about 360 mg of, and the effective amount of telmisartan is between about 40 mg and about 180 mg of telmisartan, wherein the mass ratio of is about 3:1.
7. The therapeutic combination of claim 6 , wherein the effective amount of verapamil is between about 250 and about 360 mg and the effective amount of telmisartan is at least 90 mg.
8. The therapeutic combination of claim 6 , wherein the effective amount of verapamil is about 288 mg and the effective amount of telmisartan is about 96 mg.
9. The therapeutic combination of claim 6 , wherein verapamil and telmisartan are formulated separately.
10. The therapeutic combination of claim 6 , wherein verapamil and telmisartan are formulated together.
11. The therapeutic combination of claim 6 , wherein verapamil and/or telmisartan is provided in an extended release formulation.
12. The therapeutic combination of claim 6 , wherein verapamil and/or telmisartan is provided in an extended release formulation.
13. A therapeutic combination for the treatment of a panic disorder, social anxiety disorder, or post-traumatic stress disorder in a subject in need thereof, the therapeutic combination comprising an effective amount of verapamil and telmisartan for the treatment of a panic disorder, social anxiety disorder, or post-traumatic stress disorder, wherein the mass ratio of verapamil to telmisartan is about 3:1, the effective amount of verapamil is between about 250 mg and about 360 mg, and the effective amount of the telmisartan is between about 90 mg and about 180 mg.
14. The therapeutic combination of claim 13 , wherein the effective amount of verapamil is about 288 mg and the effective amount of telmisartan is about 96 mg.
15. The therapeutic combination of claim 13 , wherein the therapeutic combination consists of verapamil and telmisartan.
16. The therapeutic combination of claim 13 , wherein the verapamil and/or telmisartan is provided in an extended release formulation.
17. The therapeutic combination of claim 13 , wherein the verapamil is provided in an extended release formulation.
18. The therapeutic combination of claim 13 , wherein the verapamil and telmisartan are formulated together.
19. The therapeutic combination of claim 13 , wherein the effective amount of the verapamil is about 288 mg and the effective amount of the telmisartan is about 96 mg.