IP Library › Granted Patent US 11,584,717
Granted Patent B2
US 11,584,717 · App. 16/229,069 · Granted Feb 21, 2023

MIF modulators

Inventors: William L. Jorgensen (Deep River, CT); Richard J. Bucala (Cos Cob, CT)
Assignee: YALE UNIVERSITY
C07D209/18C07D235/12C07D235/24C07D249/06C07D263/58C07D275/04C07D307/80C07D307/83C07D401/04C07D401/06C07D403/04C07D405/06C07D413/04C07D417/04
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Quick Facts
Patent No.
US 11,584,717
App. No.
16/229,069
Granted
Feb 21, 2023
Kind
B2
Abstract

The invention provides novel heterocyclic compounds, pharmaceutical compositions and methods of treatment that modulate levels of MIF expression and treat disorders associated with high or low levels of MIF expression.

Claims (8)

1. A compound selected from the group consisting of:

or a salt thereof.

2. A pharmaceutical composition comprising:

a compound selected from the group consisting of:

or a salt thereof;

and

a pharmaceutically acceptable carrier, additive, or excipient.

3. The pharmaceutical composition of claim 2 , further comprising an additional anticancer agent or antiviral agent.

Continuity (7)
Continuation 15656555 · Jul 21, 2017
Continuation 15401967 · Jan 9, 2017
Continuation 13100922 · May 4, 2011
Continuation In Part 12773430 · May 4, 2010
Continuation In Part PCTUS2009004704 · Aug 18, 2009
Provisional Application 61189327 · Aug 18, 2008
Related Publication 20190270706A1 · Sep 5, 2019