Levodopa sensor for tight tuning of dosage
An enzymatic sensor configured to determine the concentration of levodopa present in a sample according to a current or a resonant frequency produced in response to levodopa interactions with L-amino acid decarboxylase present in the sensor. A processor associated with the sensor determines levodopa concentration and produces dose recommendation or output according to levodopa concentration.
1. A levodopa sensor device comprising:
a processor;
a polyimide pad layer with encapsulated L-amino acid decarboxylase;
a harmonic oscillating circuit associated with the polyimide pad layer such that an electrochemical signal produced by interactions of a sample with the encapsulated L-amino acid decarboxylase will produce a resonant frequency on the circuit; and
a computer-readable program code having instructions, which when executed cause the processor to:
detect the resonant frequency obtained from the circuit; and
compute a levodopa concentration based upon the resonant frequency obtained from the circuit.
2. The device of claim 1 , further comprising a levodopa delivery component.
3. The device of claim 2 , wherein the levodopa delivery component provides a displayed oral dose recommendation according to the calculated levodopa concentration.
4. The device of claim 2 , wherein the levodopa delivery component is a duodenal pump.
5. The device of claim 4 , wherein the levodopa delivery component provides a displayed pump setting recommendation according to the calculated levodopa concentration.
6. The device of claim 4 , wherein the levodopa delivery component provides an automatic adjustment of duodenal pump settings settings according to the calculated levodopa concentration.
7. The device of claim 2 , further comprising an electrical stimulation delivery component.
8. The device of claim 7 , wherein the electrical stimulation delivery component is a deep brain stimulation (DBS) system.
9. The device of claim 7 , wherein the electrical stimulation delivery component provides a displayed electrical stimulation system setting recommendation according to the calculated levodopa concentration.
10. The device of claim 7 , wherein the electrical stimulation delivery component provides an automatic adjustment of electrical stimulation system settings according to the calculated levodopa concentration.