IP Library › Granted Patent US 11,591,544
Granted Patent B2
US 11,591,544 · App. 17/456,567 · Granted Feb 28, 2023

Ionizable cationic lipids

Inventors: Daryl C. Drummond (Lincoln, MA); Dmitri B. Kirpotin (San Francisco, CA); Mark E. Hayes (Mill Valley, CA)
Assignee: Akagera Medicines, Inc.
C11C3/003C07D317/28C07F9/091
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Quick Facts
Patent No.
US 11,591,544
App. No.
17/456,567
Granted
Feb 28, 2023
Kind
B2
Abstract

The present disclosure provides compounds useful as ionizable cationic lipids. The ionizable cationic lipids are useful for preparing lipid nanoparticles for the delivery of therapeutic nucleic acids to cells. Cationic ionizable lipids were engineered with improved stability to oxidative degradation while in storage.

Claims (16)

1. A compound selected from the group consisting of compounds 1-3 and compounds 5-8:

2. The compound of claim 1 , wherein the compound is compound 1:

3. The compound of claim 1 , wherein the compound is compound 2:

4. The compound of claim 1 , wherein the compound is compound 3:

5. The compound of claim 1 , wherein the compound is compound 5:

6. The compound of claim 1 , wherein the compound is compound 6:

7. The compound of claim 1 , wherein the compound is compound 7:

8. The compound of claim 1 , wherein the compound is compound 8:

9. A pharmaceutical composition comprising a compound selected from the group consisting of compounds 1-3 and compounds 5-8:

10. The pharmaceutical composition of claim 9 comprising the compound 1:

11. The pharmaceutical composition of claim 9 comprising the compound 2:

12. The pharmaceutical composition of claim 9 comprising the compound 3:

13. The pharmaceutical composition of claim 9 comprising the compound 5:

14. The pharmaceutical composition of claim 9 comprising the compound 6:

15. The pharmaceutical composition of claim 9 comprising the compound 7:

16. The pharmaceutical composition of claim 9 comprising the compound 8:

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 21, 2022
From: DRUMMOND, DARYL C.; KIRPOTIN, DMITRI B.; HAYES, MARK E.
To: AKAGERA MEDICINES, INC.
Reel/Frame 062168/0580 →
Continuity (2)
Provisional Application 63118534 · Nov 25, 2020
Related Publication 20220162521A1 · May 26, 2022
Cited By (5)
US 12,311,033 US 12,331,264 US 12,559,450 US 12,605,464 US 12,606,773