Methods of treating Crohn's disease and ulcerative colitis
The present disclosure is directed to methods for treating Crohn's disease, and in particular, to methods for inducing clinical remission and/or endoscopic improvement of Crohn's disease, using a JAK1 inhibitor. In certain embodiments, the patient is administered an induction dose of the JAK1 inhibitor to induce clinical remission and/or endoscopic improvement of the Crohn's disease, followed by administration of at least one maintenance dose of the JAK1 inhibitor thereafter. In other embodiments, the present disclosure is directed to methods for treating ulcerative colitis using a JAK1 inhibitor.
1. A method of treating ulcerative colitis in an adult patient having moderately to severely active ulcerative colitis to achieve clinical remission, the method comprising:
(a) orally administering to the patient an induction dose of 45 mg of upadacitinib once daily for 8 weeks; and
(b) orally administering to the patient, after the last induction dose of 45 mg of upadacitinib, a maintenance dose of 15 mg of upadacitinib once daily,
wherein the method achieves clinical remission of the ulcerative colitis in the patient.
2. The method of claim 1 , wherein the method achieves induction of clinical remission per Adapted Mayo Score at 8 weeks after the administration of the initial induction dose of 45 mg of upadacitinib.
3. The method of claim 1 , wherein the method achieves maintenance of clinical remission per Adapted Mayo Score at 52 weeks after administration of the initial maintenance dose of 15 mg of upadacitinib.
4. The method of claim 1 , wherein prior to receiving the initial induction dose the adult patient had an inadequate response or intolerance to a previous treatment with an anti-TNF agent.