SARS-COV2 spike peptides that interact with HLA-DR1 and human TLR8
View Patent ↗The multi-epitope SARS-COV2 Spike peptides are analyzed for their ability to form association or binding complex with HLA-DR1 and human TLR8 by using computer modeling and molecular docking experiments. These peptides are identified as candidates for vaccine development as well as antibody-based immunotherapy.
1. A SARS-COV2 Spike peptide consisting of any one of the amino acid sequences selected from the group of SEQ ID Numbers 7; 9; 10; 11; 12 where the peptide is a candidate for vaccine development and monoclonal antibodies for immunotherapy.
2. A composition comprising at least one SARS-COV2 Spike peptide consisting of a peptide selected from the group of SEQ ID Numbers 7; 8; 9; 10; 11; 12 where the composition can be used as multiepitope antigens to generate polyclonal antibodies and activate T cell immune responses to reduce severity of SARS-COV2 reinfection or recurring SARS-COV2 infection.