IP Library Granted Patent US 11,630,099
Granted Patent B2
US 11,630,099 · App. 16/696,783 · Granted Apr 18, 2023

Blood condition analyzing device, blood condition analyzing system, and blood condition analyzing program

Inventors: Marcaurele Brun (Tokyo, JP); Yoshihito Hayashi (Chiba, JP); Ludovic Keiser (Gentilly, FR)
Assignee: Sony Corporation
G01N33/49G01N27/06G01N27/221
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Quick Facts
Patent No.
US 11,630,099
App. No.
16/696,783
Granted
Apr 18, 2023
Kind
B2
Abstract

There is provided a blood condition analyzing device including: an extraction unit configured to use temporal change data of an electrical characteristic of blood at an arbitrary frequency to extract a feature of the data; and a blood condition evaluation unit configured to evaluate a condition change of blood from a feature extracted in the extraction unit.

Claims (52)

1. A blood analyzing system comprising:

circuitry configured to:

apply a voltage to at least one electrode configured to be arranged in electrical contact with a blood sample;

measure the electrical characteristic of the blood sample, generated by applying the voltage, at a plurality of time points and within a predetermined frequency band to generate temporal change data of the electrical characteristic of the blood sample;

select an extraction method from a plurality of extraction methods for evaluating a blood status of the blood sample;

extract a feature of the temporal change data according to the selected extraction method;

evaluate the blood status of the blood sample from the feature of the temporal change data; and

output a result based on the evaluation of the blood status of the blood sample.

2. The blood analyzing system according to claim 1 , wherein the circuitry is further configured to set an extraction criterion used to extract the feature of the temporal change data.

3. The blood analyzing system according to claim 1 , wherein the circuitry is further configured to remove noise of the temporal change data of the electrical characteristic.

4. The blood analyzing system according to claim 1 , wherein the circuitry is further configured to evaluate reliability of the temporal change data of the electrical characteristic.

5. The blood analyzing system according to claim 1 , wherein the circuitry is further configured to store an extraction result.

6. The blood analyzing system according to claim 1 , wherein the circuitry is further configured to store an evaluation result.

7. The blood analyzing system according to claim 1 , wherein the circuitry is further configured to store a measurement result.

8. The blood analyzing system according to claim 1 , further comprising:

a server configured to store a measurement result and/or an analysis result from the circuitry.

9. The blood analyzing system according to claim 8 , wherein the server is connected to the circuitry via a network.

10. The blood analyzing system according to claim 1 ,

wherein analyzing temporal change data according to the selected extraction method comprises:

determining an average amplitude M of a minimum value and a maximum value of the temporal change data;

connecting each datum in the temporal change data from a point (1, M) to obtain a plurality of line segments; and

determining a line segment with a maximum slope, and

wherein evaluating a condition change of the blood sample according to the selected extraction method comprises:

evaluating an end of blood coagulation based on a datum corresponding to the line segment.

11. The blood analyzing system according to claim 1 ,

wherein analyzing temporal change data according to the selected extraction method comprises:

determining an average amplitude M of a minimum value and a maximum value of the temporal change data;

connecting each datum in the temporal change data corresponding to a time less than T from a point (T, M) to obtain a plurality of line segments; and

determining a line segment with a maximum slope, and

wherein evaluating a condition change of the blood sample according to the selected extraction method comprises:

evaluating a start of blood coagulation based on a datum corresponding to the line segment.

12. The blood analyzing system according to claim 1 , further comprising at least one blood sample holder configured to hold the blood sample, wherein the at least one blood sample holder comprises a substrate having at least one cell provided thereon or at least one container.

13. The blood analyzing system according to claim 1 , wherein the plurality of extraction methods comprise a linear approximation method, a linear projection method, an approximation method using non-linear rational functions, and a boundary detection algorithm.

14. The blood analyzing system according to claim 1 , wherein the predetermined frequency band relates to the blood condition being analyzed.

15. The blood analyzing system according to claim 1 , wherein the blood status of the blood sample comprises a blood condition and/or a condition change of the blood sample.

16. The blood analyzing system according to claim 1 , wherein the circuitry is arranged within an electrical characteristic measuring device and/or a blood analyzing device of the blood analyzing system.

17. The blood analyzing system according to claim 16 , wherein the at least one electrode is included in the electrical characteristic measuring device, and wherein the electrical characteristic measuring device includes the circuitry configured to apply the voltage to the at least one electrode and measure the electrical characteristic of the blood sample.

18. The blood analyzing system according to claim 16 , wherein the blood analyzing device includes the circuitry configured to select the extraction method, extract the feature of the temporal change data, evaluate the blood status of the blood sample, and output the result.

19. A non-transitory computer-readable storage medium storing a blood analyzing program for causing a computer to execute:

applying a voltage to at least one electrode configured to be arranged in electrical contact with a blood sample;

measuring the electrical characteristic of the blood sample, generated by applying the voltage, at a plurality of time points and within a predetermined frequency band to generate temporal change data of the electrical characteristic of the blood sample;

selecting an extraction method from a plurality of extraction methods for evaluating a blood status of the blood sample;

extracting a feature of the temporal change data according to the selected extraction method;

evaluating the blood status of the blood sample from the feature of the temporal change data; and

outputting a result based on the evaluation of the blood status of the blood sample.

20. A method for analyzing blood comprising:

applying a voltage to at least one electrode configured to be arranged in electrical contact with a blood sample;

measuring the electrical characteristic of the blood sample, generated by applying the voltage, at a plurality of time points and within a predetermined frequency band to generate temporal change data of the electrical characteristic of the blood sample;

selecting an extraction method from a plurality of extraction methods for evaluating a blood status of the blood sample;

extracting a feature of the temporal change data according to the selected extraction method;

evaluating the blood status of the blood sample from the feature of the temporal change data; and

outputting a result based on the evaluation of the blood status of the blood sample.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 15, 2020
From: BRUN, MARCAURELE; HAYASHI, YOSHIHITO; KEISER, LUDOVIC
To: SONY CORPORATION
Reel/Frame 051597/0382 →
Priority Claims (2)
JP JP2013-050822 · Mar 13, 2013 · national
JP JP2013-263944 · Dec 20, 2013 · national
Continuity (2)
Continuation 14772483
Related Publication 20200096497A1 · Mar 26, 2020