Substituted amino triazoles useful as chitinase inhibitors
Disclosed are amino triazole compounds of formula (I). These compounds are inhibitors of acidic mammalian chitinase and chitotriosidase. Also disclosed are methods of using the compounds to treat asthma reactions caused by allergens, as well as acute and chronic inflammatory diseases, autoimmune diseases, dental diseases, neurologic diseases, metabolic diseases, liver diseases, polycystic ovary syndrome, endometriosis, and cancer.
1. A compound represented by formula (I),
wherein:
W is Cl or Br; and
R 2 is fluoro(C 1 -C 6 )alkyl;
or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 , wherein W is chloro.
3. The compound of claim 1 , wherein R 2 is fluoro(C 1 -C 2 )alkyl.
4. The compound of claim 1 , wherein R 2 is fluoro(C 1 )alkyl.
5. The compound of claim 1 , wherein R 2 is fluoro(C 2 )alkyl.
6. The compound of claim 1 , wherein R 2 is —CH 2 F.
7. The compound of claim 1 , wherein R 2 is —CHF 2 .
8. The compound of claim 1 , wherein R 2 is —CF 3 .
9. The compound of claim 1 , wherein R 2 is —CH 2 CF 3 .
10. The compound of claim 1 , wherein R 2 is —CHFCH 3 .
11. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, represented by any one of the following structural formulae:
12. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 ; and a pharmaceutically acceptable carrier.
13. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, represented by the following structure:
14. The compound of claim 1 , or a pharmaceutically acceptable salt thereof, represented by the following structure: