Use of quinoline derivatives for the treatment of inflammatory diseases
The present disclosure relates to the use of a compound of formula (I) or anyone of its pharmaceutically acceptable salts, in the treatment and/or prevention of an inflammatory disease; wherein: means an aromatic ring wherein V is C or N and when V is N; Q is N or O, provided that R″ does not exist when Q is O; R′ independently represent a hydrogen atom or a group chosen among a (C 1 -C 3 )alkyl group, a halogen atom, a hydroxyl group, a —COOR 1 group, a —NO 2 group, a —NR 1 R 2 group, a morpholinyl or a morpholino group, a N-methylpiperazinyl group, a (C 1 -C 3 )fluoroalkyl group, a —O—P(═O)—(OR 3 )(OR 4 ) group, a (C 1 -C 4 )alkoxy group and a —CN group, and can further be a group chosen among:
1. A method of treating an inflammatory disease comprising administering 8-chloro-N-[4-(trifluoromethoxy)phenyl]quinolin-2-amine, or a pharmaceutically acceptable salt thereof, to a patient in need thereof to treat the inflammatory disease, wherein the inflammatory disease is inflammatory bowel disease, Crohn's disease, or ulcerative colitis.
2. The method of claim 1 , which comprises administering 8-chloro-N-[4-(trifluoromethoxy)phenyl]quinolin-2-amine.
3. The method of claim 1 , wherein the inflammatory disease is inflammatory bowel disease.
4. The method of claim 1 , wherein the inflammatory disease is Crohn's disease.
5. The method of claim 1 , wherein the inflammatory disease is ulcerative colitis.
6. The method of claim 2 , wherein the inflammatory disease is inflammatory bowel disease.
7. The method of claim 2 , wherein the inflammatory disease is Crohn's disease.
8. The method of claim 2 , wherein the inflammatory disease is ulcerative colitis.
9. A method of treating an inflammatory disease comprising administering 8-chloro-N-[4-(trifluoromethoxy)phenyl]quinolin-2-amine, or a pharmaceutically acceptable salt thereof, to a patient in need thereof to treat the inflammatory disease, wherein the inflammatory disease is arthritis, rheumatoid arthritis, or osteoarthritis.
10. The method of claim 9 , which comprises administering 8-chloro-N-[4-(trifluoromethoxy)phenyl]quinolin-2-amine.
11. The method of claim 9 , wherein the inflammatory disease is arthritis.
12. The method of claim 9 , wherein the inflammatory disease is rheumatoid arthritis.
13. The method of claim 9 , wherein the inflammatory disease is osteoarthritis.
14. The method of claim 10 , wherein the inflammatory disease is arthritis.
15. The method of claim 10 , wherein the inflammatory disease is rheumatoid arthritis.
16. The method of claim 10 , wherein the inflammatory disease is osteoarthritis.