Implantable scaffolds for treatment of sinusitis and method of reducing inflammation
This disclosure describes, inter alia, materials, devices, kits and methods that may be used to treat chronic sinusitis. More specifically, a drug-eluting scaffold is implanted in the middle meatus to treat chronic sinusitis for weeks to months.
1. A method for reducing inflammation of the nasal tissue caused by a sinus condition in an individual in need of treatment, said method comprising delivering an expandable implant to the sinus cavity where the implant self-expands and is in apposition with the walls of the sinus cavity, wherein the implant comprises a plurality of strands, said strands comprising a conformal coating comprising an anti-inflammatory agent in an amount effective to reduce inflammation, and a conformal topcoat layer, which is disposed over the conformal coating wherein release of the anti-inflammatory agent from the implant is continuous for a period of at least 12 weeks after delivery to the sinus cavity such that inflammation is reduced, wherein the thickness of the topcoat layer causes the anti-inflammatory agent to be released in a more linear fashion.
2. The method of claim 1 wherein the sinus condition is chronic sinusitis.
3. The method of claim 1 wherein less than 15% of the anti-inflammatory agent is released during the first week after delivery of the implant.
4. The method of claim 3 wherein 20 to 80% of the agent is released during the first 12 weeks after delivery of the implant.
5. The method of claim 3 wherein 30 to 70% of the agent is released during the first 12 weeks after delivery of the implant.
6. The method of claim 3 wherein 40 to 60% of the agent is released during the first 12 weeks after delivery of the implant.
7. The method of claim 1 wherein the anti-inflammatory agent is mometasone furoate.
8. The method of claim 7 wherein the quantity of mometasone furoate initially present in the implant per unit area ranges from 0.1 μg/mm 2 to 20 μg/mm 2 .