Pyridine and pyrazine derivatives as preferential cannabinoid 2 agonists

1. A compound of formula (I)

wherein

A 1 is —CH— or nitrogen;

A 2 is —CH 2 — or carbonyl;

R 1 is haloalkoxyalkylcycloalkyl, haloalkylcycloalkyl, haloalkoxyalkyl, hydroxyalkylcycloalkyl, oxetanyl, haloalkoxyalkyloxetanyl, hydroxyalkyloxetanyl, haloalkyloxetanyl, 1-fluoroethyl, 1-fluoro-prop-2-yl, fluoro-tert.-butyl, cyclopropylfluoromethyl, fluorocyclopropyl, halooxanyl, halotetrahydrofuranyl, phenylalkoxyalkylcycloalkyl, 1-fluoro-1,1-dideuteroprop-2-yl, fluorodideuteromethyl, fluorodideuteromethyloxyalkylcycloalkyl, 2-fluoro-2,2-dideuteroethyloxyalkylcycloalkyl, fluorodideuteromethylcycloalkyl, fluorodideuteromethyloxyalkyl, fluorodideuteromethylalkyl, fluorodideuteromethyloxyalkyloxetanyl, 2-fluoro-2,2-dideuteroethyloxyalkyloxetanyl, 3-fluoro-3,3-dideuteropropyloxyalkyloxetanyl or fluorodideuteromethyloxetanyl;

R 2 is alkoxyazetidinyl, haloazetidinyl, dihaloazetidinyl, pyrrolidinyl or alkylphenylsulfonyloxyazetidinyl;

R 3 and R 4 are independently selected from hydrogen, alkyl, alkenyl and deuterioalkyl;

R 5 is hydrogen, alkyl, haloalkyl, deuterioalkyl, alkylphenylsulfonyloxyalkyl, alkylphenylsulfonyloxydeuterioalkyl or hydroxyalkyl; and

X is oxygen or —NH—;

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 , wherein A 1 is —CH—.

3. The compound of claim 1 , wherein A 2 is carbonyl.

4. The compound of claim 1 , wherein R 1 is haloalkoxyalkylcycloalkyl, haloalkylcycloalkyl or hydroxyalkylcycloalkyl.

5. The compound of claim 4 , wherein R 1 is fluoromethoxymethylcyclopropyl, fluoromethylcyclopropyl or hydroxmethylcyclopropyl.

6. The compound of claim 1 , wherein R 2 is alkoxyazetidinyl or haloazetidinyl.

7. The compound of claim 6 , wherein R 2 is methoxyazetidinyl or fluoroazetidinyl.

8. The compound of claim 1 , wherein R 3 and R 4 are both alkyl at the same time or both deuterioalkyl at the same time.

9. The compound claim 8 , wherein R 3 and R 4 are both ethyl at the same time or both dideuterioethyl at the same time.

10. The compound of claim 1 , wherein R 5 is alkyl, haloalkyl or halodeuterioalkyl.

11. The compound of claim 10 , wherein R 5 is ethyl, fluoromethyl, fluoropropyl, fluorobutyl or fluorohexadeuteriopropyl.

12. The compound of claim 1 , wherein X is oxygen.

13. The compound of claim 1 selected from the group consisting of:

Ethyl 2-ethyl-2-{[6-({(1S,2S)-2-[(fluoromethoxy)methyl]cyclopropyl}methoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-({(1R,2R)-2-[(fluoromethoxy)methyl]cyclopropyl}methoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-caronyl]amino}butanoate;

Ethyl 2-ethyl-2-{[6({(1S,2S)-2-[(2-fluoroethoxy)methyl]cyclopropyl}methoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-({(1R,2R)-2-[(2-fluoroethoxy)methyl]cyclopropyl}methoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

Ethyl 2-ethyl-2-{[6-{[(1S,2S)-2-(fluoromethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate and ethyl 2-ethyl-2-{[6-{[(1R,R)-2-(fluoromethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

Ethyl 2-ethyl-2-{[6-{[(1R,2S)-2-(fluoromethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate and ethyl 2-ethyl-2-{[6-{[(1S,2R)-2-(fluoromethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

Ethyl 2-ethyl-2-{[6-({(1R,2S)-2-[(fluoromethoxy)methyl]cyclopropyl}methoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6({(1S,2R)-2-[(fluoromethoxy)methyl]cyclopropyl}methoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

Ethyl 2-ethyl-2-{[6-({(1R,2S)-2-[(2-fluoroethoxy)methyl]cyclopropyl}methoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6({(1S,2R)-2-[(2-fluoroethoxy)methyl]cyclopropyl}methoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

Ethyl 2-ethyl-2-({6-[3-(fluoromethoxy)-2,2-dimethylpropoxy]-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl}amino)butanoate;

(+)-trans-Ethyl 2-ethyl-2-{[6-({-2-[(fluoromethoxy)methyl]cyclopropyl}methoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

(−)-trans-Ethyl 2-ethyl-2-{[6-({-2-[(fluoromethoxy)methyl]cyclopropyl}methoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-({(1R,2S)-2-[(fluoromethoxy)methyl]cyclopropyl}methoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate

ethyl 2-ethyl-2-{[6-({(1S,2R)-2-[(fluoromethoxy)methyl]cyclopropyl}methoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

(−)-trans-Fluoromethyl 2-ethyl-2-{[6-{[(1R,2R)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate; (+)-trans-Fluoromethyl 2-ethyl-2-{[6-{[-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

(+)-trans-2-Fluoroethyl 2-ethyl-2-{[6-{[-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

(−)-trans-2-Fluoroethyl 2-ethyl-2-{[6-{[-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

3-Fuoropropyl 2-ethyl-2-{[6-{[(1S,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

3-Fuoropropyl 2-ethyl-2-{[6-{[(1R,2R)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

N-[(2S)-1-(fluoromethoxy)propan-2-yl]-6-{[(1S,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-[(2S)-1-(2-fluoroethoxy)propan-2-yl]-6-{[(1S,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-[(2S)-1-(3-fluoropropoxy)propan-2-yl]-6-{[(1S,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-[(2S)-1-(fluoromethoxy)-3-methylbutan-2-yl]-6-{[(1S,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-[(2S)-1-(2-fluoroethoxy)-3-methylbutan-2-yl]-6-{[(1S,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-[(2S)-1-(3-fluoropropoxy)-3-methylbutan-2-yl]-6-{[(1S,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-[(2S)-1-(fluoromethoxy)-4-methylpentan-2-yl]-6-{[(1S,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-[(2S)-1-(2-fluoroethoxy)-4-methylpentan-2-yl]-6-{[(1S,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-[(2S)-1-(3-fluoropropoxy)-4-methylpentan-2-yl]-6-{[(1S,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-{3-[(fluoromethoxy)methyl]pentan-3-yl}-6-{[(1S,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-{3-[(2-fluoroethoxy)methyl]pentan-3-yl}-6-{[(1S,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-{3-[(3-fluoropropoxy)methyl]pentan-3-yl}-6-{[(1S,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

fluoromethyl 2-ethyl-2-{[6-{[(1R,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

2-fluoroethyl 2-ethyl-2-{[6-{[(1R,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

3-fluoropropyl 2-ethyl-2-{[6-{[(1R,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

N-[(2S)-1-(fluoromethoxy)propan-2-yl]-6-{[(1R,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-[(2S)-1-(2-fluoroethoxy)propan-2-yl]-6-{[(1R,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-[(2S)-1-(3-fluoropropoxy)propan-2-yl]-6-{[(1R,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-[(2S)-1-(fluoromethoxy)-3-methylbutan-2-yl]-6-{[(1R,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-[(2S)-1-(2-fluoroethoxy)-3-methylbutan-2-yl]-6-{[(1R,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-[(2S)-1-(3-fluoropropoxy)-3-methylbutan-2-yl]-6-{[(1R,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-[(2S)-1-(fluoromethoxy)-4-methylpentan-2-yl]-6-{[(1R,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-[(2S)-1-(2-fluoroethoxy)-4-methylpentan-2-yl]-6-{[(1R,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-[(2S)-1-(3-fluoropropoxy)-4-methylpentan-2-yl]-6-{[(1R,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-{3-[(fluoromethoxy)methyl]pentan-3-yl}-6-{[(1R,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-{3-[(2-fluoroethoxy)methyl]pentan-3-yl}-6-{[(1R,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-{3-[(3-fluoropropoxy)methyl]pentan-3-yl}-6-{[(1R,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

fluoromethyl 2-ethyl-2-({5-(3-methoxyazetidin-1-yl)-6-[(oxetan-3-yl)methoxy]pyridine-2-carbonyl}amino)butanoate;

2-fluoroethyl 2-ethyl-2-({5-(3-methoxyazetidin-1-yl)-6-[(oxetan-3-yl)methoxy]pyridine-2-carbonyl}amino)butanoate;

3-fluoropropyl 2-ethyl-2-({5-(3-methoxyazetidin-1-yl)-6-[(oxetan-3-yl)methoxy]pyridine-2-carbonyl}amino)butanoate;

N-[(2S)-1-(fluoromethoxy)propan-2-yl]-5-(3-methoxyazetidin-1-yl)-6-[(oxetan-3-yl)methoxy]pyridine-2-carboxamide;

N-[(2S)-1-(2-fluoroethoxy)propan-2-yl]-5-(3-methoxyazetidin-1-yl)-6-[(oxetan-3-yl)methoxy]pyridine-2-carboxamide;

N-[(2S)-1-(3-fluoropropoxy)propan-2-yl]-5-(3-methoxyazetidin-1-yl)-6-[(oxetan-3-yl)methoxy]pyridine-2-carboxamide;

N-[(2S)-1-(fluoromethoxy)-3-methylbutan-2-yl]-5-(3-methoxyazetidin-1-yl)-6-[(oxetan-3-yl)methoxy]pyridine-2-carboxamide;

N-[(2S)-1-(2-fluoroethoxy)-3-methylbutan-2-yl]-5-(3-methoxyazetidin-1-yl)-6-[(oxetan-3-yl)methoxy]pyridine-2-carboxamide;

N-[(2S)-1-(3-fluoropropoxy)-3-methylbutan-2-yl]-5-(3-methoxyazetidin-1-yl)-6-[(oxetan-3-yl)methoxy]pyridine-2-carboxamide;

N-[(2S)-1-(fluoromethoxy)-4-methylpentan-2-yl]-5-(3-methoxyazetidin-1-yl)-6-[(oxetan-3-yl)methoxy]pyridine-2-carboxamide;

N-[(2S)-1-(2-Fluoroethoxy)-4-methylpentan-2-yl]-5-(3-methoxyazetidin-1-yl)-6-[(oxetan-3-yl)methoxy]pyridine-2-carboxamide;

N-[(2S)-1-(3-fluoropropoxy)-4-methylpentan-2-yl]-5-(3-methoxyazetidin-1-yl)-6-[(oxetan-3-yl)methoxy]pyridine-2-carboxamide;

N-{3-[(fluoromethoxy)methyl]pentan-3-yl}-5-(3-methoxyazetidin-1-yl)-6-[(oxetan-3-yl)methoxy]pyridine-2-carboxamide;

N-{3-[(2-fluoroethoxy)methyl]pentan-3-yl}-5-(3-methoxyazetidin-1-yl)-6-[(oxetan-3-yl)methoxy]pyridine-2-carboxamide;

N-{3-[(3-fluoropropoxy)methyl]pentan-3-yl}-5-(3-methoxyazetidin-1-yl)-6-[(oxetan-3-yl)methoxy]pyridine-2-carboxamide;

N-[(2S)-1-(2-Fluoroethoxy)-4-methylpentan-2-yl]-6-[(oxetan-3-yl)methoxy]-5-(pyrrolidin-1-yl)pyridine-2-carboxamide;

ethyl 2-ethyl-2-{[6-({3-[(fluoromethoxy)methyl]oxetan-3-yl}methoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-({3-[(2-fluoroethoxy)methyl]oxetan-3-yl}methoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-({3-[(3-fluoropropoxy)methyl]oxetan-3-yl}methoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

fluoromethyl 2-ethyl-2-{[6-{[3-(hydroxymethyl)oxetan-3-yl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

2-fluoroethyl 2-ethyl-2-{[6-{[3-(hydroxymethyl)oxetan-3-yl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

3-fluoropropyl 2-ethyl-2-{[6-{[3-(hydroxymethyl)oxetan-3-yl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

N-[(2S)-1-(fluoromethoxy)propan-2-yl]-6-{[3-(hydroxymethyl)oxetan-3-yl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-[(2S)-1-(2-fluoroethoxy)propan-2-yl]-6-{[3-(hydroxymethyl)oxetan-3-yl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-[(2S)-1-(3-fluoropropoxy)propan-2-yl]-6-{[3-(hydroxymethyl)oxetan-3-yl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-[(2S)-1-(fluoromethoxy)-3-methylbutan-2-yl]-6-{[3-(hydroxymethyl)oxetan-3-yl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-[(2S)-1-(2-fluoroethoxy)-3-methylbutan-2-yl]-6-{[3-(hydroxymethyl)oxetan-3-yl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-[(2S)-1-(3-fluoropropoxy)-3-methylbutan-2-yl]-6-{[3-(hydroxymethyl)oxetan-3-yl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-[(2S)-1-(fluoromethoxy)-4-methylpentan-2-yl]-6-{[3-(hydroxymethyl)oxetan-3-yl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-[(2S)-1-(2-fluoroethoxy)-4-methylpentan-2-yl]-6-{[3-(hydroxymethyl)oxetan-3-yl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-[(2S)-1-(3-fluoropropoxy)-4-methylpentan-2-yl]-6-{[3-(hydroxymethyl)oxetan-3-yl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-{3-[(fluoromethoxy)methyl]pentan-3-yl}-6-{[3-(hydroxymethyl)oxetan-3-yl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-{3-[(2-fluoroethoxy)methyl]pentan-3-yl}-6-{[3-(hydroxymethyl)oxetan-3-yl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-{3-[(3-fluoropropoxy)methyl]pentan-3-yl}-6-{[3-(hydroxymethyl)oxetan-3-yl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

6-({(1S,2S)-2-[(fluoromethoxy)methyl]cyclopropyl}methoxy)-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

6-({(1S,2S)-2-[(2-fluoroethoxy)methyl]cyclopropyl}methoxy)-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

6-({(1S,2S)-2-[(3-fluoropropoxy)methyl]cyclopropyl}methoxy)-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

6-{[(1S,2S)-2-(fluoromethyl)cyclopropyl]methoxy}-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

6-({(1R,2S)-2-[(fluoromethoxy)methyl]cyclopropyl}methoxy)-N-[(2S)-1-hydroxy-3-methylbutan-2-yl]-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

6-({(1R,2S)-2-[(2-fluoroethoxy)methyl]cyclopropyl}methoxy)-N-[(2S)-1-hydroxy-3-methylbutan-2-yl]-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

6-({(1R,2S)-2-[(3-fluoropropoxy)methyl]cyclopropyl}methoxy)-N-[(2S)-1-hydroxy-3-methylbutan-2-yl]-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

6-{[(1R,2S)-2-(fluoromethyl)cyclopropyl]methoxy}-N-[(2S)-1-hydroxy-3-methylbutan-2-yl]-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

6-({3-[(fluoromethoxy)methyl]oxetan-3-yl}methoxy)-N-[(2S)-1-hydroxypropan-2-yl]-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

6-({3-[(2-fluoroethoxy)methyl]oxetan-3-yl}methoxy)-N-[(2S)-1-hydroxypropan-2-yl]-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

6-({3-[(3-fluoropropoxy)methyl]oxetan-3-yl}methoxy)-N-[(2S)-1-hydroxypropan-2-yl]-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

6-{[3-(fluoromethyl)oxetan-3-yl]methoxy}-N-[(2S)-1-hydroxypropan-2-yl]-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

6-({3-[(fluoromethoxy)methyl]oxetan-3-yl}methoxy)-N-[3-(hydroxymethyl)pentan-3-yl]-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

6-({3-[(2-fluoroethoxy)methyl]oxetan-3-yl}methoxy)-N-[3-(hydroxymethyl)pentan-3-yl]-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

6-({3-[(3-fluoropropoxy)methyl]oxetan-3-yl}methoxy)-N-[3-(hydroxymethyl)pentan-3-yl]-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

6-{[3-(fluoromethyl)oxetan-3-yl]methoxy}-N-[3-(hydroxymethyl)pentan-3-yl]-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

ethyl 2-ethyl-2-{[6-({(1S,2S)-2-[(fluoromethoxy)methyl]cyclopropyl}methoxy)-5-(3-methoxyazetidin-1-yl)pyrazine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-({(1R,2S)-2-[(fluoromethoxy)methyl]cyclopropyl}methoxy)-5-(3-methoxyazetidin-1-yl)pyrazine-2-carbonyl]amino}butanoate;

6-({(1S,2S)-2-[(3-fluoropropoxy)methyl]cyclopropyl}methoxy)-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]-5-(3-methoxyazetidin-1-yl)pyrazine-2-carboxamide;

6-({(1R,2S)-2-[(3-fluoropropoxy)methyl]cyclopropyl}methoxy)-N-[(2S)-1-hydroxy-3-methylbutan-2-yl]-5-(3-methoxyazetidin-1-yl)pyrazine-2-carboxamide;

ethyl 2-ethyl-2-({6-[(3-fluorooxan-4-yl)methoxy]-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl}amino)butanoate;

1,4-anhydro-2,3-dideoxy-5-O-[6-{[3-(ethoxycarbonyl)pentan-3-yl]carbamoyl}-3-(3-methoxyazetidin-1-yl)pyridin-2-yl]-2-fluoropentitol;

ethyl 2-ethyl-2-{[6-{[3-fluoro-2-methyl(3,3-dideuterio)propyl]oxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-{[2-fluoro(2,2-dideuterio)ethyl]oxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-({6-[(3-fluorooxan-4-yl)methoxy]-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl}amino)butanoate;

1,4-anhydro-2,3-dideoxy-5-O-[6-{[3-(ethoxycarbonyl)pentan-3-yl]carbamoyl}-3-(3-methoxyazetidin-1-yl)pyridin-2-yl]-2-fluoropentitol;

ethyl 2-ethyl-2-{[6-{[(1S,2S)-2-({[fluoro(dideuterio)methyl]oxy}methyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-{[(1S,2S)-2-({[2-fluoro(2,2-˜2˜H_2_)ethyl]oxy}methyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-({(1S,2S)-2-[fluoro(dideuterio)methyl]cyclopropyl}methoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-({(1R,2S)-2-[fluoro(dideuterio)methyl]cyclopropyl}methoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-{[(1R,2S)-2-({[fluoro(dideuterio)methyl]oxy}methyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-{[(1R,2S)-2-({[2-fluoro(2,2-dideuterio)ethyl]oxy}methyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-(3-{[fluoro(dideuterio)methyl]oxy}-2,2-dimethylpropoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-{[3-fluoro-2,2-dimethyl(3,3-dideuterio)propyl]oxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-{[(1S,2S)-2-({[fluoro(dideuterio)methyl]oxy}methyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-{[(1R,2R)-2-({[fluoro(dideuterio)methyl]oxy}methyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-{[3-fluoro-2-methyl(3,3-dideuterio)propyl]oxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-{[2-fluoro(2,2-dideuterio)ethyl]oxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-{[3-fluoro-2-methyl(3,3-dideuterio)propyl]oxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-{[3-fluoro-2-methyl(3,3-dideuterio)propyl]oxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-{[2-fluoro(2,2-dideuterio)ethyl]oxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-{[3-fluoro-2-methyl(3,3-dideuterio)propyl]oxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

6-{[3-({[fluoro(dideuterio)methyl]oxy}methyl)oxetan-3-yl]methoxy}-N-[(2S)-1-hydroxypropan-2-yl]-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

6-{[3-({[2-fluoro(2,2-dideuterio)ethyl]oxy}methyl)oxetan-3-yl]methoxy}-N-[(2S)-1-hydroxypropan-2-yl]-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

6-{[3-({[3-fluoro(3,3-dideuterio)propyl]oxy}methyl)oxetan-3-yl]methoxy}-N-[(2S)-1-hydroxypropan-2-yl]-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

6-({3-[fluoro(dideuterio)methyl]oxetan-3-yl}methoxy)-N-[(2S)-1-hydroxypropan-2-yl]-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

6-{[3-({[fluoro(dideuterio)methyl]oxy}methyl)oxetan-3-yl]methoxy}-N-[3-(hydroxymethyl)pentan-3-yl]-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

6-{[3-({[2-fluoro(2,2-dideuterio)ethyl]oxy}methyl)oxetan-3-yl]methoxy}-N-[3-(hydroxymethyl)pentan-3-yl]-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

6-{[3-({[3-fluoro(3,3-dideuterio)propyl]oxy}methyl)oxetan-3-yl]methoxy}-N-[3-(hydroxymethyl)pentan-3-yl]-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

6-({3-[fluoro(dideuterio)methyl]oxetan-3-yl}methoxy)-N-[3-(hydroxymethyl)pentan-3-yl]-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

3-Fluoropropyl 3,4-dideuterio-2-(1,2-dideuterioethyl)-2-[[6-[[(1S,2S)-2-(hydroxymethyl)cyclopropyl]methoxy]-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino]butanoate;

fluoromethyl 2-ethyl-2-(6-((3-(hydroxymethyl)oxetan-3-yl)methoxy)-5-(pyrrolidin-1-yl)picolinamido)butanoate;

2-fluoroethyl 2-ethyl-2-(6-((3-(hydroxymethyl)oxetan-3-yl)methoxy)-5-(pyrrolidin-1-yl)picolinamido)butanoate;

3-fluoropropyl 2-ethyl-2-(6-((3-(hydroxymethyl)oxetan-3-yl)methoxy)-5-(pyrrolidin-1-yl)picolinamido)butanoate;

(1,1,2,2,3,3-Hexadeuterio-3-fluoro-propyl) 2-ethyl-2-[[6-[[(1S,2S)-2-(hydroxymethyl)cyclopropyl]methoxy]-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino]butanoate;

3-Fluoropropyl 2-[[6-[[(1S,2S)-2-(hydroxymethyl)cyclopropyl]methoxy]-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino]-2-vinyl-but-3-enoate;

3-Fluoropropyl 3,4-dideuterio-2-(1,2-dideuterioethyl)-2-[[6-[[(1S,2S)-2-(hydroxymethyl)cyclopropyl]methoxy]-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino]butanoate;

(Rac)-trans-3-Fluoropropyl 2-[[6-[[(1S,2S)-2-(benzyloxymethyl)cyclopropyl]methoxy]-5-(3-hydroxyazetidin-1-yl)pyridine-2-carbonyl]amino]-2-ethyl-butanoate;

3-(p-Tolylsulfonyloxy)propyl 2-ethyl-2-[[6-[[(1S,2S)-2-(hydroxymethyl)cyclopropyl]methoxy]-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino]butanoate;

[1,1,2,2,3,3-Hexadeuterio-3-(p-tolylsulfonyloxy)propyl]2-ethyl-2-[[6-[[(1S,2S)-2-(hydroxymethyl)cyclopropyl]methoxy]-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino]butanoate;

4-Fluorobutyl 2-ethyl-2-[[6-[[(1S,2S)-2-(hydroxymethyl)cyclopropyl]methoxy]-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino]butanoate;

N-[1-Ethyl-1-[[(1S)-1-(hydroxymethyl)-3-methyl-butyl]carbamoyl]propyl]-6-[[(1S,2S)-2-(hydroxymethyl)cyclopropyl]methoxy]-5-(3-methoxyazetidin-1-yl)pyridine-2-carboxamide;

N-[1-ethyl-1-[[(1S)-1-(hydroxymethyl)-3-methyl-butyl]carbamoyl]propyl]-5-(3-fluoroazetidin-1-yl)-6-[[(1R,2R)-2-(hydroxymethyl)cyclopropyl]methoxy]pyridine-2-carboxamide;

N-[1-Ethyl-1-[[(1S)-1-(hydroxymethyl)-3-methyl-butyl]carbamoyl]propyl]-5-(3-fluoroazetidin-1-yl)-6-[[(1S,2S)-2-(hydroxymethyl)cyclopropyl]methoxy]pyridine-2-carboxamide;

3-Fluoropropyl 2-ethyl-2-{[5-(3-fluoroazetidin-1-yl)-6-{[(1R,2R)-2-(hydroxymethyl)cyclopropyl]methoxy}pyridin-2-yl]formamido}butanoate;

3-Fluoropropyl 2-ethyl-2-{[5-(3-fluoroazetidin-1-yl)-6-{[(1S,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}pyridin-2-yl]formamido}butanoate;

(Rac)-trans-3-fluoropropyl 2-ethyl-2-[[6-[[-2-(hydroxymethyl)cyclopropyl]methoxy]-5-[3-(p-tolylsulfonyloxy)azetidin-1-yl]pyridine-2-carbonyl]amino]butanoate;

3-Fluoropropyl 2-[[6-[[(1S,2S)-2-(benzyloxymethyl)cyclopropyl]methoxy]-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino]-2-ethyl-butanoate;

ethyl 2-ethyl-2-{[6-(2-fluoropropoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-(3-fluoro-2-methylpropoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-(3-fluoro-2,2-dimethylpropoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-(3-fluoro-2-methylpropoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-({6-[(1-fluorocyclopropyl)methoxy]-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl}amino)butanoate;

ethyl 2-ethyl-2-({6-[(2-fluorocyclopropyl)methoxy]-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl}amino)butanoate;

ethyl 2-ethyl-2-{[6-(2-fluoropropoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-(3-fluoro-2-methylpropoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-(3-fluoro-2-methylpropoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-({6-[(1-fluorocyclopropyl)methoxy]-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl}amino)butanoate; and

ethyl 2-ethyl-2-({6-[(2-fluorocyclopropyl)methoxy]-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl}amino)butanoate;

or a pharmaceutically acceptable salt thereof.

14. The compound of claim 1 selected from the group consisting of:

Ethyl 2-ethyl-2-{[6-({(1S,2S)-2-[(fluoromethoxy)methyl]cyclopropyl}methoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate and ethyl 2-ethyl-2-{[6-({(1R,2R)-2-[(fluoromethoxy)methyl]cyclopropyl}methoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

Ethyl 2-ethyl-2-{[6-({(1S,2S)-2-[(2-fluoroethoxy)methyl]cyclopropyl}methoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-({(1R,2R)-2-[(2-fluoroethoxy)methyl]cyclopropyl}methoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

Ethyl 2-ethyl-2-{[6-{[(1R,2S)-2-(fluoromethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-{[(1S,2R)-2-(fluoromethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

Ethyl 2-ethyl-2-{[6-({(1R,2S)-2-[(fluoromethoxy)methyl]cyclopropyl}methoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

ethyl 2-ethyl-2-{[6-({(1S,2R)-2-[(fluoromethoxy)methyl]cyclopropyl}methoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

(+)-trans-Ethyl 2-ethyl-2-{[6({-2-[(fluoromethoxy)methyl]cyclopropyl}methoxy)-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

(+)-trans-Fluoromethyl 2-ethyl-2-{[6-{[-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

3-Fuoropropyl 2-ethyl-2-{[6-{[(1S,2S)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate; and

3-Fuoropropyl 2-ethyl-2-{[6-{[(1R,2R)-2-(hydroxymethyl)cyclopropyl]methoxy}-5-(3-methoxyazetidin-1-yl)pyridine-2-carbonyl]amino}butanoate;

or a pharmaceutically acceptable salt thereof.

15. A process for the preparation of the compound of claim 1 , comprising one of the following steps:

(a) the reaction of a compound of formula (A1)

with a compound of formula (A2)

in the presence of a coupling agent and a base;

(b) the reaction of a compound of formula (B)

in the presence of R 2 M, a palladium catalyst and a base;

wherein:

A 1 is —CH— or nitrogen;

A 2 is —CH 2 — or carbonyl;

R 1 is haloalkoxyalkylcycloalkyl, haloalkylcycloalkyl, haloalkoxyalkyl, hydroxyalkylcycloalkyl, oxetanyl, haloalkoxyalkyloxetanyl, hydroxyalkyloxetanyl, haloalkyloxetanyl, 1-fluoroethyl, 1-fluoro-prop-2-yl, fluoro-tert.-butyl, cyclopropylfluoromethyl, fluorocyclopropyl, halooxanyl, halotetrahydrofuranyl, phenylalkoxyalkylcycloalkyl, 1-fluoro-1,1-dideuteroprop-2-yl, fluorodideuteromethyl, fluorodideuteromethyloxyalkylcycloalkyl, 2-fluoro-2,2-dideuteroethyloxyalkylcycloalkyl, fluorodideuteromethylcycloalkyl, fluorodideuteromethyloxyalkyl, fluorodideuteromethylalkyl, fluorodideuteromethyloxyalkyloxetanyl, 2-fluoro-2,2-dideuteroethyloxyalkyloxetanyl, 3-fluoro-3,3-dideuteropropyloxyalkyloxetanyl or fluorodideuteromethyloxetanyl;

R 2 is alkoxyazetidinyl, haloazetidinyl, dihaloazetidinyl, pyrrolidinyl or alkylphenylsulfonyloxyazetidinyl;

R 3 and R 4 are independently selected from hydrogen, alkyl, alkenyl and deuterioalkyl;

R 5 is hydrogen, alkyl, haloalkyl, deuterioalkyl, alkylphenylsulfonyloxyalkyl, alkylphenylsulfonyloxydeuterioalkyl or hydroxyalkyl;

X is oxygen or —NH—; and

Y is halogen.

16. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof, and a therapeutically inert carrier.