Partially buffered free acid and/or ketone blend compositions for rapid onset ketosis and metabolic therapy
A foodstuff can include a free acid β-hydroxybutyrate, and a base. The β-hydroxybutyrate, and base, are present at a less than 1:1 molar equivalence. Ketone Ester may also be incorporated as a component of the foodstuff.
1. A foodstuff comprising a mixture of β-hydroxybutyric acid salts; β-hydroxybutyric acid; 1,3-butanediol; and a ketone ester, wherein the β-hydroxybutyric acid; the salts of β-hydroxybutyric acid; 1,3-butanediol; and ketone ester are present in a molar ratio of 5:5:1:5; 5:5:2:5, or 10:5:2:5.
2. The food stuff of claim 1 wherein the ketone ester is 3-hydroxybutyl 3-hydroxybutanoate
3. The foodstuff of claim 1 , wherein the mixture of β-hydroxybutyric acid salts comprises at least two of sodium β-hydroxybutyrate, calcium β-hydroxybutyrate, potassium β-hydroxybutyrate, and magnesium β-hydroxybutyrate.
4. The foodstuff of claim 1 , wherein β-hydroxybutyric acid and the salts of β-hydroxybutyric acid are enantiomerically enriched with respect to the D form or are in the enantiomerically pure D form.
5. The foodstuff of claim 2 , wherein 3-hydroxybutyl 3-hydroxybutanoate is (D)-3-hydroxybutyl (D)-3-hydroxybutanoate,
6. The food stuff of claim 1 , wherein the 1,3-butanediol is racemic, enantiomerically pure (D)-1,3-butanediol, or wherein the 1,3-butanediol is enriched with respect to (D)-1,3-butanediol.
7. A foodstuff comprising:
a. about 1% to about 49% ketone ester
b. β-hydroxybutyric acid
c. about 1% to about 25% of a mixture of β-hydroxybutyric acid salts, wherein the mixture of salts comprises at least two of sodium β-hydroxybutyrate, calcium β-hydroxybutyrate, potassium β-hydroxybutyrate, and magnesium 3-hydroxybutyrate;
wherein the salts of β-hydroxybutyric acid and β-hydroxybutyric acid are enantiomerically enriched with respect to the D form or are in the enantiomerically pure D form,
8. The foodstuff of claim 7 wherein the ketone ester is (D)-3-hydroxybutyl (D)-3-hydroxybutanoate.
9. The foodstuff of claim 7 , wherein the mixture of salts comprises at least two of sodium β-hydroxybutyrate, calcium β-hydroxybutyrate, potassium β-hydroxybutyrate, and magnesium β-hydroxybutyrate.