IP Library › Granted Patent US 11,666,761
Granted Patent B2
US 11,666,761 · App. 17/027,453 · Granted Jun 6, 2023

Machine learning to optimize spinal cord stimulation

Inventors: Michael A. Moffitt (Solon, OH); Natalie A. Brill (Sherman Oaks, CA); Jianwen Gu (Valencia, CA); Juan Gabriel Hincapie Ordonez (Maple Grove, MN); Changfang Zhu (Valencia, CA); Hemant Bokil (Santa Monica, CA); Stephen Carcieri (Los Angeles, CA)
Assignee: Boston Scientific Neuromodulation Corporation
A61N1/36135A61N1/025A61N1/3605A61N1/36007A61N1/36071A61N1/37247G16H50/20A61N1/36003A61N1/36132A61N1/36146G16H20/30G16H50/70
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Quick Facts
Patent No.
US 11,666,761
App. No.
17/027,453
Granted
Jun 6, 2023
Kind
B2
Abstract

An example of a system may include a processor and a memory device comprising instructions, which when executed by the processor, cause the processor to: access a patient metric of a subject; use the patient metric as an input to a machine learning algorithm, the machine learning algorithm to search a plurality of neuromodulation parameter sets and to identify a candidate neuromodulation parameter set of the plurality of neuromodulation parameter sets, the candidate neuromodulation parameter set designed to produce a non-regular waveform that varies over a time domain and a space domain; and program a neuromodulator using the candidate neuromodulation parameter set to stimulate the subject.

Claims (36)

1. A system comprising:

a processor; and

a memory device comprising instructions, which when executed by the processor, cause the processor to:

access a pain level of a subject;

use the pain level to identify a candidate neuromodulation parameter set for a use by a neuromodulator to deliver a non-regular electrical waveform for neuromodulation using electrodes, wherein the non-regular electrical waveform varies in distribution of modulation energy fractionalized across the electrodes; and

enable the neuromodulator to treat patient pain using the candidate neuromodulation parameter set to electrically stimulate the subject using the non-regular electrical waveform that varies in the distribution.

2. The system of claim 1 , wherein the processor is configured to use a genetic algorithm to identify the candidate neuromodulation parameter set.

3. The system of claim 1 , wherein the processor is configured to use a neural network to identify the candidate neuromodulation parameter set.

4. The system of claim 1 , wherein the system is a cloud-based system, and wherein the instructions to provide the candidate neuromodulation parameter set comprise instructions to transmit the candidate neuromodulation parameter set to a client device of the cloud-based system.

5. The system of claim 1 , wherein the pain level is an objective pain metric.

6. The system of claim 5 , wherein the pain level is a physiological indication sensed by a sensor worn by the subject.

7. The system of claim 1 , wherein the pain level is a subjective pain metric.

8. The system of claim 1 , wherein the non-regular waveform varies fractionalization or polarity of at least one parameter.

9. The system of claim 1 , wherein the candidate neuromodulation parameter set is designed to produce a pulse burst that varies pulse-by-pulse.

10. The system of claim 1 , wherein the processor is configured to use a machine learning algorithm, and the memory device further comprises instructions, which when executed by the processor, cause the processor to:

receive from a user, a selected parameter; and

focus the machine learning algorithm using the selected parameter.

11. The system of claim 1 , wherein the non-regular electrical waveform has waveform components that vary in at least one of timing, size or shape.

12. A method comprising:

accessing, at a computerized system, a pain level of a subject;

using the pain level to identify a candidate neuromodulation parameter set for a use by a neuromodulator to deliver a non-regular electrical waveform for neuromodulation using electrodes, wherein the non-regular waveform varies in distribution of modulation energy fractionalized across the electrodes;

use the candidate neuromodulation parameter set to enable the neuromodulator to electrically stimulate the subject using the non-regular electrical waveform that varies in the distribution; and

using the neuromodulator to produce the non-regular waveform that varies in the distribution.

13. The method of claim 12 , further comprising using a genetic algorithm to identify the candidate neuromodulation parameter.

14. The method of claim 12 , wherein the candidate neuromodulation parameter set is designed to produce a pulse burst that varies pulse-by-pulse.

15. The method of claim 12 , further comprising:

receiving from a user, a selected parameter; and

using the selected parameter to focus an algorithm to identify a candidate neuromodulation parameter.

16. The method of claim 12 , wherein the non-regular electrical waveform has waveform components that vary in at least one of timing, size or shape.

17. A non-transitory machine-readable medium including instructions, which when executed by a machine, cause the machine to:

access a pain level of a subject;

use the pain level to identify a candidate neuromodulation parameter set for a use by a neuromodulator to deliver a non-regular electrical waveform for neuromodulation using electrodes, wherein the non-regular electrical waveform varies in distribution of modulation energy fractionalized across the electrodes; and

enable the neuromodulator to treat pain using the candidate neuromodulation parameter set by electrically stimulating the subject using the non-regular electrical waveform that varies in the distribution.

18. The non-transitory machine-readable medium of claim 17 , wherein the non-regular electrical waveform has waveform components that vary in at least one of timing, size or shape.

19. The non-transitory machine-readable medium of claim 17 , wherein a genetic algorithm is used to identify the candidate neuromodulation parameter set.

20. The non-transitory machine-readable medium of claim 17 , wherein a neural network is used to identify the candidate neuromodulation parameter set.

Continuity (4)
Continuation 15244913 · Aug 23, 2016
Provisional Application 62277686 · Jan 12, 2016
Provisional Application 62210221 · Aug 26, 2015
Related Publication 20210069512A1 · Mar 11, 2021