IP Library › Granted Patent US 11,678,859
Granted Patent B2
US 11,678,859 · App. 16/572,328 · Granted Jun 20, 2023

Systems and methods for rendering of cardiac electromechanical activation

Inventors: Elisa Konofagou (New York, NY); Pierre Nauleau (New York, NY); Elaine Wan (Fresh Meadows, NY); Lea Melki (New York, NY); Julien Grondin (New York, NY)
Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
A61B8/0883A61B8/4416A61B8/4488A61B8/485A61B8/5223A61B8/5261A61B2576/023
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Quick Facts
Patent No.
US 11,678,859
App. No.
16/572,328
Granted
Jun 20, 2023
Kind
B2
Abstract

Systems and methods for generating an electromechanical map are disclosed herein. The methods includes obtaining ultrasound data comprising a series of consecutive image frames and radio frequency (RF) signals corresponding to the location in the heart; measuring displacements and strains based on the ultrasound data to determine an electromechanical activation in the location; converting the ultrasound data into a series of isochrone maps; and combining the series of isochrone maps to generate the electromechanical map. The electromechanical map illustrates the electromechanical activation and internal wall structures of the heart.

Claims (30)

1. A method for generating an electromechanical map corresponding to a location of a heart from ultrasound data generated using an ultrasound beam, comprising:

obtaining ultrasound data including a series of image frames and radio frequency (RF) signals corresponding to the location;

measuring displacements and strains based on the ultrasound data to determine an electromechanical activation in the location;

converting the ultrasound data into a series of isochrone maps, wherein the series of isochrone maps illustrates the electromechanical activation, wherein the series of isochrone maps comprises at least four isochrone maps;

determining a median axis of each of the isochrone maps;

determining a location of an internal wall structure of the heart and a value of the electromechanical activation at the location of the internal wall structure at a point of the median axis in the isochrone maps, wherein the values of the electromechanical activation are determined from at least eight locations of the internal wall structure; and

generating the electromechanical map by combining the locations and the value of the electromechanical activation wherein the electromechanical map is a three-dimensional (3D) map configured to illustrate the internal wall structure of the heart at the location.

2. The method of claim 1 , wherein the ultrasound data corresponds to multiple apical views of the location.

3. The method of claim 1 , wherein the determining the electromechanical activation further includes beamforming the RF signals.

4. The method of claim 1 , wherein the determining the electromechanical activation comprises identifying zero-crossings of the strains at the location of the heart.

5. The method of claim 4 , wherein the converting the ultrasound data into the series of isochrone maps further comprises interpolating the zero-crossings into the series of isochrone maps to show the electromechanical activation over time.

6. The method of claim 1 , further comprising obtaining an electrocardiography (ECG) signal to align the series of image frames and RF signals.

7. The method of claim 1 , wherein the ultrasound data is obtained over a duration of one or more cardiac cycles.

8. The method of claim 1 , wherein the electromechanical map illustrates the electromechanical activation, the displacements, and the strains over a duration of one or more cardiac cycles.

9. The method of claim 1 , further comprising obtaining a segmented image of the heart from the series of image frames.

10. The method of claim 1 , further comprising performing a linear interpolation between the at least eight locations.

11. A system for generating an electromechanical map corresponding to a location of a heart from ultrasound data generated using an ultrasound beam, comprising:

at least one ultrasound system, configured to obtain ultrasound data comprising a series of image frames and radio frequency (RF) signals corresponding to the location; and

a processor, coupled to the system, and configured to

measure displacements and strains based on the ultrasound data to determine an electromechanical activation in the location;

convert the ultrasound data into a series of isochrone maps, wherein the series of isochrone maps comprises at least four isochrone maps;

determine a median axis of each of the isochrone maps;

determine a location of an internal wall structure of the heart and a value of the electromechanical activation at the location of the internal wall structure at a point of the median axis in the isochrone maps, wherein the values of the electromechanical activation are determined from at least eight locations of the internal wall structure; and

generate the electromechanical map by combining the locations and the value of the electromechanical activation, wherein the electromechanical map is a three-dimensional (3D) map configured to illustrate the internal wall structures of the heart at the location.

12. The system of claim 11 , wherein the processor is further configured to identify zero-crossings of the strains at the location of the heart based on the ultrasound data.

13. The system of claim 11 , wherein the at least one ultrasound system comprises a 2D array including a plurality of transducer elements.

14. The system of claim 11 , wherein the at least one ultrasound system is configured to perform a diverging imaging sequence and/or a focused wave imaging sequence.

15. The system of claim 11 , wherein the processor is further configured to generate a heart model for an electromechanical simulation and an ultrasound simulation based on the series of image frames and radio frequency (RF) signals corresponding to the location in the heart.

16. The system of claim 11 , wherein the processor is further configured to obtain a segmented image of the heart from the series of image frames.

17. The system of claim 11 , the processor is configured to perform a linear interpolation between the at least eight locations.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 25, 2019
From: GRONDIN, JULIEN
To: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Reel/Frame 050823/0599 →
Continuity (4)
Continuation PCTUS2018022950 · Mar 16, 2018
Provisional Application 62474834 · Mar 22, 2017
Provisional Application 62473124 · Mar 17, 2017
Related Publication 20200214662A1 · Jul 9, 2020