Macrocycles

1. A macrocycle having a structure selected from Formula (I)-(III):

wherein

B 1 , and B 2 are independently selected from N, B, and P;

L 1 , L 2 , L 3 , L 4 , L 5 , L 6 , L 7 , and L 8 are independently selected from substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl and substituted or unsubstituted heterocycloalkyl;

each A b1 , A b2 , each and A b3 is independently selected from Formulae (1)-(5):

each R 6 , R 7 , R 8 , R 9 , and R 10 is independently selected from a bond to L 2 , L 3 , L 4 , L 6 , L 7 , or L 8 , alkanediyl attached to L 2 , L 3 , L 4 , L 6 , L 7 , or L 8 ,

each R 6 , R 7 , R 8 , R 9 , and R 10 which is not a bond to L 2 , L 3 , L 4 , L 5 , L 6 , L 7 , or L 8 , or alkanediyl attached to L 2 , L 3 , L 4 , L 5 , L 6 , L 7 , or L 8 is independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, halogen, CN, —CF 3 , —C(O)R 17 , —SO 2 NR 17 R 18 , —N 17 R 18 , —OR 17 , —S(O) 2 R 17 , —COOR 17 , —S(O) 2 OR 17 , —OC(O)R 17 , —C(O)NR 17 R 18 , —NR 17 C(O)R 18 , —NR 17 SO 2 R 18 , and —NO 2 ,

A p1 is a member selected from Formulae (1′)-(5′):

one of R 6′ , R 7′ , R 8′ , R 9′ , and R 10′ is selected from a bond to L 5 , and each R 6′ , R 7′ , R 8′ , R 9′ , and R 10′ which is not a bond to L 5 is independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, halogen, CN, —CF 3 , —C(O)R 17 , —SO 2 NR 17 R 18 , —NR 17 R 18 , —OR 17 , —S(O) 2 R 17 , —COOR 17 , —S(O) 2 OR 17 , —OC(O)R 17 , —C(O)NR 17 R 18 , —NR 17 C(O)R 18 , —NR 17 SO 2 R 18 , and —NO 2 ;

each R 17 and R 18 is independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl and substituted or unsubstituted heterocycloalkyl, wherein

R 17 and R 18 , together with the atoms to which they are attached, are optionally joined to form a 5-, 6- or 7-membered ring;

A b1 is attached to L 2 and L 6 through two members selected from R 6 , R 7 , R 8 , R 9 and R 10 ;

A b2 is attached to L 3 and L 7 through two members selected from R 6 , R 7 , R 8 , R 9 and R 10 ;

A b3 is attached to L 4 and L 8 through two members selected from R 6 , R 7 , R 8 , R 9 and R 10 ; and

A p1 is attached to L 5 through a member selected from R 6′ , R 7′ , R 8′ , R 9′ and R 10′ .

2. The macrocycle according to claim 1 , wherein said macrocycle is covalently modified with at least one linker.

3. The macrocycle according to claim 2 , wherein one of L 1 , L 2 , L 3 , L 4 , L 5 , L 6 , L 7 , L 8 , and A p1 is substituted with a linker.

4. The macrocycle according to claim 2 , wherein said linker is attached to a targeting moiety which is a member selected from the group consisting of an antibody, a protein, a peptide, and DNA.

5. The macrocycle according to claim 1 , wherein

when A b1 has a structure according to Formula (1), A b1 is attached to L 2 and L 6 through R 6 and R 10 ;

when A b1 has a structure according to Formula (2a), (3), (4) or (5), A b1 is attached to L 2 and L 6 through R 6 and R 9 ;

when A b2 has a structure according to Formula (1), A b2 is attached to L 3 and L 7 through R 6 and R 10 ;

when A b2 has a structure according to Formula (2a), (3), (4) or (5), A b2 is attached to L 3 and L 7 through R 6 and R 9 ;

when A b3 has a structure according to Formula (1), A b3 is attached to L 4 and L 8 through R 6 and R 10 ;

when A b3 has a structure according to Formula (2a), (3), (4) or (5), A b3 is attached to L 4 and L 8 through R 6 and R 9 ;

when A p1 has a structure according to Formula (1), A p1 is attached to L 5 through R 6′ or R 10′ ; and

when A p1 has a structure according to Formula (2a), (3), (4) or (5), A p1 is attached to L 5 through R 6′ or R 9′ .

6. The macrocycle according to claim 1 , having the structure:

wherein L x1 is H or a linker.

7. The macrocycle according to claim 1 , having the structure:

8. The macrocycle according to according to claim 1 , having the structure:

wherein n is 1, 2, 3, 4, 5, or 6; and

L x1 is H or a linker.

9. The macrocycle according to claim 1 , wherein said macrocycle comprises one or more modifying moieties.

10. The macrocycle according to claim 9 , wherein one or more L 1 , L 2 , L 3 , L 4 , L 5 , L 6 , L 7 , L 8 , and A p1 comprises a modifying moiety.

11. The macrocycle according to claim 9 , wherein said modifying moiety is a substituted or unsubstituted polyether.

12. The macrocycle according to claim 1 , wherein L 5 comprises a cleavable bond.

13. A complex comprising a macrocycle according to claim 1 and a metal ion bound thereto.

14. The complex according to claim 13 , wherein the metal is selected from a lanthanide, an actinide, yttrium (Y), and zirconium (Zr).

15. The complex according to claim 14 , wherein said lanthanide is selected from terbium (Tb), europium (Eu), dysprosium (Dy), and lutetium (Lu).

16. The complex according to claim 14 , wherein said actinide is thorium (Th).

17. The complex according to claim 13 , wherein said metal is a radionuclide.

18. The complex according to claim 17 , wherein said metal ion is 227 Th(IV) or 89 Zr(IV).