Method for treating nervous system injuries using boldine and analogs thereof
Provided are methods of treating an injury to the nervous system in a subject comprising administering to the subject an effective amount of boldine, a boldine analog, or a pharmaceutically-acceptable salt thereof. Also provided are methods of improving voluntary muscle control and methods of treating neuropathic pain in a subject having an injury to the nervous system. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
1. A method of treating spinal cord injury (SCI) in a subject, comprising administering to the subject an effective amount of a compound represented by a formula:
or a pharmaceutically-acceptable salt thereof, thereby treating the SCI in the subject.
2. The method of claim 1 , wherein the compound is represented by the formula:
3. The method of claim 1 , wherein the compound is orally administered to the subject.
4. The method of claim 1 , wherein the compound intravenously administered to the subject.
5. The method of claim 1 , wherein the compound is administered up to 24 hours after the SCI.
6. A method of treating a SCI in a subject, the method comprising intravenously administering to the subject an effective amount of a compound having a structure represented by a formula:
or a pharmaceutically acceptable salt thereof,
wherein the compound is intravenously administered up to 24 hours after the SCI.
7. The method of claim 6 , wherein the compound is represented by the formula: