Substituted bicyclic compounds as farnesoid X receptor modulators

1. A compound of Formula (I):

or a stereoisomer, a tautomer, or a salt or solvate thereof, wherein:

X 1 is CR 5a or N;

X 2 is CR 5b or N;

X 3 is CR 5c or N;

X 4 is CR 5d or N; provided that zero, 1, or 2 of X 1 , X 2 , X 3 , and X 4 are N;

Z 1 and Z 2 are independently CH 2 or O; provided that at least one of Z 1 and Z 2 is CH 2 ;

a is zero or 1;

b is zero, 1, or 2;

d is zero, 1, or 2; provided that Z 1 and Z 2 are each CH 2 when a, b, and d are each zero;

Q is a cyclic group selected from cyclopropyl, spiro[3.3]heptenyl, bicyclo[2.2.2]octanyl, azetidinyl, morpholinyl, oxaazaspiro[3.3]heptanyl, piperazinyl, piperidinyl, [1,2,4]triazolo[1,5-a] pyridinyl, [1,2,4]triazolo[4,3-a]pyridinyl, 1H-pyrazolo[3,4-b] pyridinyl, 2,3-dihydrobenzo[d]oxazolyl, 7,8-dihydro-5H-pyrano[4,3-b]pyridinyl, benzo[d][1,3]dioxolyl, benzo[d]oxazolyl, benzo[d]thiazolyl, imidazo[1,2-a]pyridinyl, imidazo[1,2-b]pyridazinyl, imidazolyl, indazolyl, indolinyl, isoxazolyl, oxadiazolyl, oxazolyl, pyrazinyl, pyrazolyl, pyridazinyl, pyridinyl, pyrimidinyl, pyrrolo[2,1-f] [1,2,4]triazinyl, quinolinyl, tetrahydropyridinyl, thiazolo[4,5-b]pyridinyl, thiazolo[5,4-b] pyridinyl, thiazolyl, thieno[3,2-b]pyridinyl, and triazolyl, wherein said cyclic group is substituted with zero to 2 R 1 ;

each R 1 is independently hydrogen, halo, cyano, hydroxyl, oxo, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, —NH 2 , —NH(C 1-6 alkyl), —N(C 1-6 alkyl) 2 , —C(O)(C 1-6 alkyl), —C(O)(C 3-6 cycloalkyl), —NR x C(O)R y , —C(O)OR x , —C(O)NR w R w , —S(O) 2 (C 1-6 alkyl), —S(O) 2 (C 3-6 cycloalkyl), —NR x S(O) 2 (C 1-6 alkyl), —NR x S(O) 2 (C 3-6 cycloalkyl), —S(O) 2 NR z R z , —P(O)R y R y , —(CH 2 ) 0-3 (C 3-6 carbocyclyl), —O(C 3-6 cycloalkyl), —O(4- to 6-membered heterocyclyl), (CH 2 ) 0-3 (4- to 6-membered heterocyclyl), or —(CH 2 ) 0-3 (5- or 6-membered heteroaryl), wherein each of said alkyl, alkoxy, alkenyl, and alkynyl is substituted with zero to 4 R 1a and each of said cycloalkyl, heterocyclyl, and heteroaryl is substituted with zero to 4 R 1b ;

each R 1a is independently halo, hydroxyl, —NR w R w , oxo, cyano, C 1-3 alkoxy, C 1-3 haloalkoxy, —C(O)OR x , —C(O)NR w R w , or —NR x C(O)R y ;

each R 1b is independently halo, oxo, cyano, hydroxyl, —NH 2 , C 1-6 alkyl, C 1-6 alkoxy, —NH(C 1-6 alkyl), —N(C 1-6 alkyl) 2 , or —NR x C(O)(C 1-6 alkyl), wherein each of said alkyl and alkoxy is substituted with zero to 6 R 1a ;

R 2 is:

(i) C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, or —NR v R y , wherein each of said alkyl, alkenyl, alkynyl, and alkoxy is substituted with zero to 6 R 2a ;

(ii) C 3-5 carbocyclyl, C 6-8 spirobicyclyl, or 4- to 5-membered heterocyclyl, wherein each of said carbocyclyl, spirobicyclyl, and heterocyclyl is substituted with zero to 3 R 2b ; or

(iii) —CH 2 (C 3-6 cycloalkyl), —CH 2 (4- to 6-membered heterocyclyl), —NR x (CH 2 ) 0-2 (C 3-6 cycloalkyl), —NR x (CH 2 ) 0-2 (C 5-8 bicycloalkyl), —NR x (CH 2 ) 0-2 (C 5-8 spirobicyclyl), —NR x (CH 2 ) 0-2 (4- to 6-membered heterocyclyl), —NR x (CH 2 ) 0-2 (5- to 6-membered heteroaryl), —NR x (CH 2 ) 0-2 (phenyl), —O(CH 2 ) 0-2 (C 3-6 cycloalkyl), —O(CH 2 ) 0-2 (C 5-8 bicycloalkyl), —O(CH 2 ) 0-2 (C 5-8 spirobicyclyl), O(CH 2 ) 0-2 (4- to 6-membered heterocyclyl), O(CH 2 ) 0-2 (5- to 6-membered heteroaryl), or —O(CH 2 ) 0-2 (phenyl), wherein each of said cycloalkyl, heterocyclyl, bicycloalkyl, spirobicyclyl, aryl, and heteroaryl is substituted with zero to 3 R 2b ,

each R 2a is independently halo, cyano, hydroxyl, oxo, C 1-3 haloalkyl, C 1-3 alkoxy, C 1-3 haloalkoxy, —NR x R x , —C(O)(C 1-6 alkyl), —C(O)(C 3-6 cycloalkyl), —NR x C(O)R y , —C(O)(C 1-6 alkyl), —C(O)OR x , —C(O)NR w R w , —S(O) 2 R y , —S(O) 2 (C 1-3 fluoroalkyl), —NR x S(O) 2 (C 1-3 alkyl), —NR x S(O) 2 (C 3-6 cycloalkyl), —S(O) 2 NR z R z , or —P(O)R y R y ;

each R 2b is independently halo, cyano, hydroxyl, oxo, C 1-6 alkyl, C 1-6 alkoxy, —NR x R x , —NR x C(O)O(C 1-4 alkyl), —C(O)(C 1-3 alkyl), or —S(O) 2 (C 1-3 alkyl), wherein each of said alkyl and alkoxy is substituted with zero to 6 R 2ª;

R 3a and R 3b are independently hydrogen, C 1-3 alkyl, C 1-3 haloalkyl, or C 3-6 cycloalkyl, or R 3a and R 3b , taken together with the carbon atom to which they are attached, form a C 3-6 cycloalkyl;

A is oxadiazolyl substituted with zero to 3R 4a ;

each R 4a is independently halo, cyano, hydroxyl, —NH 2 , C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, —(CH 2 ) 0-3 NH(C 1-6 alkyl), —(CH 2 ) 0-2 N(C 1-6 alkyl) 2 , —(CH 2 ) 0-3 (C 3-6 cycloalkyl), or —(CH 2 ) 0-3 (4- to 6-membered heterocyclyl), wherein each of said alkyl, alkoxy, alkenyl, and alkynyl is substituted with zero to 6 R 4d and each of said cycloalkyl and heterocyclyl is substituted with zero to 3 R 4e ;

each R 4d is independently halo, hydroxyl, —NR x R x , oxo, cyano, C 1-3 alkoxy, or C 1-3 haloalkoxy;

each R 4e is independently halo, oxo, cyano, hydroxyl, —NH 2 , C 1-6 alkyl, C 1-6 alkoxy, —NH(C 1-6 alkyl), or —N(C 1-6 alkyl) 2 , wherein each of said alkyl and alkoxy is substituted with zero to 6 R 4d each of R 5a , R 5b , R 5c , and R 5d is independently hydrogen, halo, hydroxy, cyano, C 1-6 alkyl substituted with zero to 6 R 5e , C 1-6 alkoxy substituted with zero to 6 R 5e , —C(O)OR x , —C(O)NR w R w , —S(O) 2 R y , —S(O) 2 NR z R z , or phenyl substituted with zero to 3 R 5f ;

each of R 5e is independently halo, hydroxyl, —NR x R x , oxo, cyano, C 1-3 alkoxy, or C 1-3 haloalkoxy;

each R 5f is independently halo, oxo, cyano, hydroxyl, —NH 2 , C 1-6 alkyl, C 1-6 alkoxy, —NH(C 1-6 alkyl), or —N(C 1-6 alkyl) 2 , wherein each of said alkyl and alkoxy is substituted with zero to 6 R 5e ;

each R v is independently hydrogen, C 1-6 alkyl, or alternatively, two R v , taken together with the nitrogen atom to which they are attached, form a 4- to 7-membered bicyclic or spirocyclic ring moiety containing zero to 2 additional heteroatoms independently selected from N, O, and S, wherein each ring can be substituted with zero to 6 R 2a ;

each R w is independently hydrogen, C 1-6 alkyl, or C 3-6 cycloalkyl; or alternatively, two R w , taken together with the nitrogen atom to which they are attached, form a 4- to 7-membered ring moiety containing zero to 2 additional heteroatoms independently selected from N, O, and S;

each R x is independently hydrogen, C 1-6 alkyl, or C 3-6 cycloalkyl;

each R y is independently C 1-6 alkyl or C 3-6 cycloalkyl; and

each R z is independently hydrogen, C 1-6 alkyl, or C 3-6 cycloalkyl; or alternatively, two R z , taken together with the nitrogen atom to which they are attached, form a 4- to 7-membered ring moiety containing zero to 2 additional heteroatoms independently selected from N, O, and S.

2. The compound according to claim 1 or a stereoisomer, a tautomer, or a salt or solvate thereof, wherein:

each R 1 is independently F, Cl, Br, cyano, hydroxyl, oxo, —NR x R x , C 1-5 alkyl, C 1-4 alkoxy, —NR x (C 1-4 alkyl), —NR x C(O)R y , —C(O)(C 1-4 alkyl), —C(O)OR x , —C(O)NR w R w , —S(O) 2 (C 1-4 alkyl), —S(O) 2 (C 3-6 cycloalkyl), —NR x S(O) 2 (C 1-4 alkyl), —NR x S(O) 2 (C 3-6 cycloalkyl), —S(O) 2 NR z R z , —P(O)R y R y , —(CH 2 ) 0-3 (C 3-6 carbocyclyl), —O(C 3-6 cycloalkyl), —O(4- to 6-membered heterocyclyl), —(CH 2 ) 0-3 (4- to 6-membered heterocyclyl), or —(CH 2 ) 0-3 (5- or 6-membered heteroaryl), wherein each of said alkyl and alkoxy is substituted with zero to 4 R 1a and each of said cycloalkyl, heterocyclyl, and heteroaryl is substituted with zero to 3 R 1b ;

each R 1a is independently F, Cl, hydroxyl, —NR w R w , oxo, cyano, C 1-3 alkoxy, C 1-3 haloalkoxy, or C(O)OH;

each R 1b is independently F, Cl, cyano, hydroxyl, oxo, —NH 2 , C 1-4 alkyl, C 1-4 alkoxy, —NH(C 1-4 alkyl), —N(C 1-4 alkyl) 2 , or —NR x C(O) (C 1-6 alkyl), wherein each of said alkyl and alkoxy is substituted with zero to 6 R 1a ;

R 2 is:

(i) C 1-4 alkyl, C 1-5 alkoxy, or —NR v R v , wherein each of said alkyl and alkoxy is substituted with zero to 4 R 2a ;

(ii) C 3-5 carbocyclyl, C 6-8 spirobicyclyl, or 4- to 5-membered heterocyclyl, wherein each of said carbocyclyl, spirobicyclyl, and heterocyclyl is substituted with zero to 3 R 2b ; or

(iii) —CH 2 (C 3-5 cycloalkyl), —CH 2 (4- to 6-membered heterocyclyl), —NR x (CH 2 ) 0-2 (C 3-6 cycloalkyl), —NR x (CH 2 ) 0-2 (C 6-8 spirobicyclyl), —NR x (CH 2 ) 0-2 (4- to 6-membered heterocyclyl), —NR x (CH 2 ) 0-2 (phenyl), —O(4- to 6-membered heterocyclyl), —O(phenyl), or —O(pyridinyl), wherein each of said cycloalkyl, spirobicyclyl, heterocyclyl, phenyl, and pyridinyl is substituted with zero to 3 R 2b ;

each R 2a is independently F, Cl, hydroxyl, —NR x R x , oxo, cyano, C 1-3 alkoxy, C 1-3 haloalkoxy, or —C(O)OH;

each R 2b is independently F, Cl, cyano, hydroxyl, C 1-4 alkyl, C 1-3 alkoxy, —NR x R x , —NR x C(O)O(C 1-4 alkyl), —C(O)(C 1-2 alkyl), or —S(O) 2 (C 1-2 alkyl), wherein each of said alkyl and alkoxy is substituted with zero to 4 R 2a ;

each R 4a is independently F, Cl, cyano, hydroxyl, —NH 2 , C 1-4 alkyl, C 1-4 alkoxy, —(CH 2 ) 0-3 NH(C 1-6 alkyl), —(CH 2 ) 0-3 N(C 1-6 alkyl) 2 , —(CH 2 ) 0-3 (C 3-6 cycloalkyl), or (CH 2 ) 0-3 (4- to 6-membered heterocyclyl), wherein each of said alkyl and alkoxy is substituted with zero to 4 R 4d ; and each of said cycloalkyl and heterocyclyl is substituted with zero to 3 R 4e ;

each R 4d is independently F, Cl, hydroxyl, —NR x R x , oxo, cyano, C 1-3 alkoxy, or C 1-3 fluoroalkoxy;

each R 4e is independently F, Cl, oxo, cyano, hydroxyl, —NH 2 , C 1-4 alkyl, C 1-4 alkoxy, or —NH(C 1-6 alkyl), or —N(C 1-6 alkyl) 2 , wherein each of said alkyl and alkoxy is substituted with zero to 4 R 4d ;

each of R 5a , R 5b , R 5c , and R 5d is independently hydrogen, F, Cl, hydroxy, cyano, C 1-3 alkyl substituted with zero to 4 R 5e , C 1-3 alkoxy substituted with zero to 4 R 5e , —C(O)OR x , —C(O)NR w R w , —S(O) 2 R y , —S(O) 2 NR z R z , or phenyl substituted with zero to 3 R 5f ;

each R w is independently hydrogen, C 1-4 alkyl, or C 3-6 cycloalkyl; or alternatively, two R w , taken together with the nitrogen atom to which they are attached, form a 4- to 7-membered ring moiety containing zero to 2 additional heteroatoms independently selected from N, O, and S;

each R x is independently H, C 1-4 alkyl, or C 3-6 cycloalkyl;

R y is C 1-4 alkyl or C 3-6 cycloalkyl; and

each R z is independently hydrogen, C 1-4 alkyl, or C 3-6 cycloalkyl; or alternatively, two R z , taken together with the nitrogen atom to which they are attached, form a 4- to 7-membered ring moiety containing zero to 2 additional heteroatoms independently selected from N, O, and S.

3. The compound according to claim 1 or a stereoisomer, a tautomer, or a salt or solvate thereof, wherein:

X 1 is CR 5a ;

X 2 is CR 5b or N;

X 3 is CR 5c or N;

X 4 is CR 5d or N; provided that zero, 1, or 2 of X 2 , X 3 , and X 4 is N;

Z 1 and Z 2 are independently CH 2 or O; provided that at least one of Z 1 and Z 2 is CH 2 ;

a is 1;

b is 1;

d is 1;

each R 1 is independently hydrogen, F, Cl, Br, cyano, hydroxyl, oxo, C 1-4 alkyl, C 1-2 fluoroalkyl, —CH 2 C 1 , C 1-4 hydroxyalkyl, —C(CH 3 ) 2 CN, —CH(OH)CHF 2 , —CH 2 OCH 3 , C 1-4 alkoxy, C 1-2 fluoroalkoxy, —OCF 2 Cl, —OC(CH 3 ) 2 CN, —C(CH 3 ) 2 OCHF 2 , —OC(CH 3 ) 2 C(O)NH 2 , —C(O)OH, —C(O)O(C 1-2 alkyl), —C(O)NH 2 , —O(cyclopropyl), —CH 2 (cyclopropyl), —CH 2 (oxetanyl), —NHC(O)CH 3 , —NHS(O) 2 CH 3 , —NHS(O) 2 CH(CH 3 ) 2 , —NHS(O) 2 CF 3 , —NHS(O) 2 (cyclopropyl), —S(O) 2 CH 3 , —S(O) 2 (cyclopropyl), —S(O) 2 NH 2 , cyclopropyl, acetamidocyclopropyl, cyanocyclopropyl, difluorocyclobutyl, hydroxycyclopropyl, methoxycyclopropyl, cyclohexenyl, dihydropyranyl, oxetanyl, methyloxetanyl, tetrahydropyranyl, aminooxadiazolyl, pyridinyl, or fluorobicyclo[1.1.1]pentyl;

R 2 is:

(i) C 1-4 alkyl, C 1-5 alkoxy, or —NH(C 1-6 alkyl), wherein each of said alkyl and alkoxy is substituted with zero to 4 R 2a ,

(ii) C 3-5 carbocyclyl, C 6-8 spirobicyclyl, or 4- to 5-membered heterocyclyl, wherein each of said carbocyclyl, spirobicyclyl, and heterocyclyl is substituted with zero to 3 R 2b ; or

(iii) —CH 2 (C 3-5 cycloalkyl), —CH 2 (4- to 6-membered heterocyclyl), —NR x (CH 2 ) 0-2 (C 3-6 cycloalkyl), —NR x (CH 2 ) 0-2 (C 6-8 spirobicyclyl), —NR x (CH 2 ) 0-2 (4- to 6-membered heterocyclyl), —NR x (CH 2 ) 0-2 (phenyl), —O(tetrahydropyranyl), —O(phenyl), or —O(pyridinyl), wherein each of said cycloalkyl, spirobicyclyl, heterocyclyl, phenyl, and pyridinyl is substituted with zero to 3 R 2b ;

each R 2a is independently F, cyano, hydroxyl, C 1-2 alkoxy, or —NR x R x ;

each R 2b is independently F, cyano, hydroxyl, C 1-3 alkyl, C 1-2 fluoroalkyl, C 1-3 hydroxyalkyl, C 1-2 alkoxy, C 1-2 fluoroalkoxy, —NR x R x , —NR x C(O)O(C 1-4 alkyl), —C(O)(C 1-2 alkyl), —C(O)(C 1-2 fluoroalkyl), or —S(O) 2 (C 1-2 alkyl);

one of R 3a and R 3b is hydrogen and the other of R 3a and R 3b is hydrogen or —CH 3 ;

A is oxadiazolyl substituted with zero to 2 R 4a ;

each R 4a is independently cyano, —CH 3 , ≠CH(CH 3 ) 2 , —C(CH 3 ) 3 , —CHF 2 , —CF 3 , —CF 2 CH 3 , —C(CH 3 ) 2 F, —C(CH 3 ) 2 OH, —C(CH 3 ) 2 CN, —OCH 3 , —C(O)N(CH 3 ) 2 , —CH 2 (cyclopropyl), cyclopropyl, fluorocyclopropyl, methylcyclopropyl, cyanocyclopropyl, trifluoromethylcyclopropyl, difluorocyclopropyl, methyloxetanyl, tetrahydropyranyl, or fluorobicyclo[1.1.1]pentyl; and

each of R 5a , R 5b , R 5c , and R 5d is hydrogen.

4. The compound according to claim 1 or a stereoisomer, a tautomer, or a salt or solvate thereof, wherein:

X 1 is CH;

X 2 is CH or N;

X 3 is CH or N;

X 4 is CH; provided that zero or 1 of X 2 and X 3 are N;

Z 1 and Z 2 are independently CH 2 or O; provided that at least one of Z 1 and Z 2 is CH 2 ;

a is 1;

b is 1;

d is 1;

Q is a cyclic group selected from cyclopropyl, azetidinyl, imidazolyl, isoxazolyl, oxazolyl, oxadiazolyl, pyrazolyl, thiazolyl, triazolyl, morpholinyl, piperazinyl, pyrazinyl, pyridazinyl, pyridinyl, pyrimidinyl, indazolyl, indolinyl, [1,2,4]triazolo[1,5-a]pyridinyl, [1,2,4]triazolo[4,3-a]pyridinyl, 1H-pyrazolo[3,4-b] pyridinyl, 2,3-dihydrobenzo[d]oxazolyl, 7,8-dihydro-5H-pyrano[4,3-b]pyridinyl, benzo[d]dioxolyl, benzo[d]thiazolyl, imidazo[1,2-a]pyridinyl, imidazo[1,2-b] pyridazinyl, pyrrolo[2,1-f] [1,2,4]triazinyl, thiazolo[4,5-b]pyridinyl, thiazolo[5,4-b] pyridinyl, thieno[3,2-b] pyridinyl, and quinolinyl, wherein said cyclic group is substituted with zero to 2 R 1 ;

each R 1 is independently C 1-4 alkyl, —CHF 2 , —CF 3 , —CH 2 CF 3 , —CF 2 CH 3 , —CH 2 CHF 2 , —C(CH 3 ) 2 OH, —CH 2 OCH 3 , —C(CH 3 ) 2 OCH 3 , —OCH 3 , —OCH 2 CH 3 , —OC(CH 3 ) 2 CN, —C(CH 3 ) 2 OCHF 2 , —C(O)OCH 3 , —C(O)OCH 2 CH 3 , —CH 2 (cyclopropyl), —S(O) 2 CH 3 , —S(O) 2 (cyclopropyl), ═O, difluorocyclobutyl, fluorobicyclo[1.1.1]pentyl, oxetanyl, methyl oxetanyl, pyridinyl tetrahydropyranyl, or cyclopropyl substituted with zero to 1 substituent selected from hydroxyl, —CH 3 , —OCH 3 , and —NHC(O)CH 3 ;

R 2 is —CH(CH 3 ) 2 , —NHCH 2 CH 3 , —NHCH 2 C(CH 3 ) 3 , —NH(methyl cyclopropyl), —NH(methoxyphenyl), or a cyclic group selected from C 3-5 cycloalkyl, azetidinyl, oxetanyl, pyrrolidinyl, and bicyclo[1.1.1]pentyl, each cyclic group substituted with zero to 2 substituents independently selected from F, hydroxyl, cyano, —CH 3 , —CHF 2 , —CF 3 , —C(CH 3 ) 2 OH, —OCH 3 , —OCH 2 CH 3 , —NH 2 , —N(CH 3 ) 2 , —NHC(O)OC(CH 3 ) 3 , and —C(O)CF 3 ;

R 3a is hydrogen or —CH 3 ;

R 3b is hydrogen; and

A is oxadiazolyl substituted with zero to 2 substituents independently selected from cyano, fluorobicyclo[1.1.1]pentyl, C 1-4 alkyl, C 1-3 fluoroalkyl, —C(CH 3 ) 2 CN, —C(CH 3 ) 2 OH, —OCH 3 , —C(O)N(CH 3 ) 2 , —CH 2 (cyclopropyl), cyclopropyl, fluorocyclopropyl, difluorocyclopropyl, trifluoromethylcyclopropyl, cyanocyclopropyl, methylcyclopropyl, methyl oxetanyl, and tetrahydropyranyl.

5. The compound according to claim 1 or a stereoisomer, a tautomer, or a salt or solvate thereof, having the structure:

6. The compound according to claim 5 or a stereoisomer, a tautomer, or a salt or solvate thereof, wherein:

A is oxadiazolyl substituted with R 4 ª; and

R 2 is:

(i) C 1-4 alkyl, C 1-5 alkoxy, or —NH(C 1-6 alkyl), wherein each of said alkyl and alkoxy is substituted with zero to 4 R 2a , or

(ii) C 3-5 cycloalkyl substituted with zero to 3 R 2b .

7. The compound according to claim 1 or a stereoisomer, a tautomer, or a salt or solvate thereof, having the structure:

8. The compound according to claim 7 or a stereoisomer, a tautomer, or a salt or solvate thereof, wherein:

A is oxadiazolyl substituted with R 4a ; and

R 2 is:

(i) C 1-4 alkyl, C 1-5 alkoxy, or —NH(C 1-6 alkyl), wherein each of said alkyl and alkoxy is substituted with zero to 4 R 2a ; or

ii) C 3-5 cycloalkyl substituted with zero to 3 R 2b .

9. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound according to claim 1 , or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt or solvate thereof.

10. A method of treating a disease or disorder, comprising administering to a mammalian patent a compound according to claim 1 or a pharmaceutically acceptable salt thereof, wherein said disease or disorder is pathological fibrosis, metabolic disorders, or cholestatic disorders.

11. The method according to claim 10 , wherein the pathological fibrosis is liver fibrosis, renal fibrosis, biliary fibrosis, or pancreatic fibrosis.

12. The method according to claim 10 , wherein said disease or disorder is nonalcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), chronic kidney disease, diabetic kidney disease, primary sclerosing cholangitis (PSC), or primary biliary cirrhosis (PBC).

13. The method according to claim 10 , wherein said disease or disorder is idiopathic pulmonary fibrosis (IPF).

14. The compound according to claim 1 or a salt thereof, wherein said compound is:

N-(3-(3-ethyl-1,2,4-oxadiazol-5-yl)phenyl)-3-fluoro-N-((4-(3-methyl-1,2,4-oxadiazol-5-yl) bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (3);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-(difluoromethyl)-N-(3-(3-ethyl-1,2,4-oxadiazol-5-yl)phenyl)cyclobutane-1-carboxamide (4);

(1S,3S)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(3-ethyl-1,2,4-oxadiazol-5-yl)phenyl)-3-hydroxy-3-(trifluoromethyl)cyclobutane-1-carboxamide (5);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(3-ethyl-1,2,4-oxadiazol-5-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (6);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-ethoxyoxazol-5-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (7);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (8);

(1S,3S)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-3-hydroxy-3-(trifluoromethyl)cyclobutane-1-carboxamide (9);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-3,3-difluorocyclobutane-1-carboxamide (10);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-3,3-difluorocyclopentane-1-carboxamide (11);

ethyl 2-(3-(3-fluoro-N-((4-(3-methyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl) methyl)bicyclo[1.1.1]pentane-1-carboxamido)phenyl)oxazole-4-carboxylate (12);

ethyl 2-(3-(N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamido)phenyl)oxazole-4-carboxylate (13);

N-(3-(4-(chloromethyl)oxazol-2-yl)phenyl)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl) bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (14);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(4-(2-hydroxypropan-2-yl)oxazol-2-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (15);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3,3-difluoro-N-(3-(4-(2-hydroxypropan-2-yl)oxazol-2-yl)phenyl)cyclobutane-1-carboxamide (16);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-(difluoromethyl)-N-(3-(4-(2-hydroxypropan-2-yl)oxazol-2-yl)phenyl)cyclobutane-1-carboxamide (17);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3,3-difluoro-N-(3-(4-(2-hydroxypropan-2-yl)oxazol-2-yl)phenyl)cyclopentane-1-carboxamide (18);

(1S,3S)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-hydroxy-N-(3-(3-(2-hydroxypropan-2-yl)-1,2,4-oxadiazol-5-yl)phenyl)-3-(trifluoromethyl) cyclobutane-1-carboxamide (19);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-cyclopropyloxazol-5-yl)phenyl)cyclobutanecarboxamide (20);

(1S,3S)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-cyclopropyloxazol-5-yl)phenyl)-3-hydroxy-3-(trifluoromethyl)cyclobutane-1-carboxamide (21);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-cyclopropyloxazol-5-yl)phenyl)-3,3-difluorocyclobutane-1-carboxamide (22);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-cyclopropyloxazol-5-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (23);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-cyclopropyloxazol-5-yl)phenyl)-3-(difluoromethyl)cyclobutane-1-carboxamide (24);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-ethoxyisoxazol-3-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (25);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-propyloxazol-5-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (26);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3,3-difluoro-N-(3-(2-propyloxazol-5-yl)phenyl)cyclobutane-1-carboxamide (27);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-(difluoromethyl)-N-(3-(2-propyloxazol-5-yl)phenyl)cyclobutane-1-carboxamide (28);

ethyl 4-(3-(N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamido)phenyl)thiazole-2-carboxylate (29);

N-(3-(2-(chloromethyl)thiazol-4-yl)phenyl)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl) bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (30);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-(2-hydroxypropan-2-yl)thiazol-4-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (31);

3-Fluoro-N-((4-(3-methyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-(tetrahydro-2H-pyran-4-yl)oxazol-5-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (34);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-(tetrahydro-2H-pyran-4-yl)oxazol-5-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (35);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3,3-difluoro-N-(3-(2-(tetrahydro-2H-pyran-4-yl)oxazol-5-yl)phenyl)cyclobutane-1-carboxamide (36);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(4-(difluoromethyl)oxazol-2-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (40);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(4-(difluoromethyl)oxazol-2-yl)phenyl)-3,3-difluorocyclobutane-1-carboxamide (41);

(1S,3S)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(4-(difluoromethyl)oxazol-2-yl)phenyl)-3-hydroxy-3-(trifluoromethyl)cyclobutane-1-carboxamide (42);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-(difluoromethyl)-N-(3-(4-(difluoromethyl)oxazol-2-yl)phenyl)cyclobutane-1-carboxamide (43);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(4-(difluoromethyl)oxazol-2-yl)phenyl)-3,3-difluorocyclopentane-1-carboxamide (44);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-ethoxy-1,3,4-oxadiazol-2-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (53);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-ethoxy-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-ethoxy-1,3,4-oxadiazol-2-yl)phenyl)cyclobutanecarboxamide (54);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-ethoxy-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-ethoxy-1,3,4-oxadiazol-2-yl)phenyl)-3,3-difluorocyclopentane-1-carboxamide (55);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-(difluoromethyl)-N-(3-(5-ethoxy-1,3,4-oxadiazol-2-yl)phenyl)cyclobutane-1-carboxamide (56);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-cyclopropylisoxazol-3-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (57);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-cyclopropylisoxazol-3-yl)phenyl)-3-(difluoromethyl)cyclobutane-1-carboxamide (58);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-cyclopropylisoxazol-3-yl)phenyl)-3,3-difluorocyclopentane-1-carboxamide (59);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-cyclopropylisoxazol-3-yl)phenyl)-3,3-difluorocyclobutane-1-carboxamide (60);

N-((4-(3-(cyclopropylmethyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(3-(cyclopropylmethyl)-1,2,4-oxadiazol-5-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (61);

N-((4-(3-(cyclopropylmethyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-N-((4-(3-(cyclopropylmethyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(3-(cyclopropylmethyl)-1,2,4-oxadiazol-5-yl)phenyl)-3,3-difluorocyclopentane-1-carboxamide (62);

N-((4-(3-(cyclopropylmethyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(3-(cyclopropylmethyl)-1,2,4-oxadiazol-5-yl)phenyl)-3,3-difluorocyclobutane-1-carboxamide (63);

N-((4-(3-(cyclopropylmethyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-N-((4-(3-(cyclopropylmethyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(3-(cyclopropylmethyl)-1,2,4-oxadiazol-5-yl)phenyl)cyclobutanecarboxamide (64);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(3-(cyclopropylmethyl)-1,2,4-oxadiazol-5-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (65);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(3-(cyclopropylmethyl)-1,2,4-oxadiazol-5-yl)phenyl)cyclobutanecarboxamide (66);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(3-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(3-(cyclopropylmethyl)-1,2,4-oxadiazol-5-yl)phenyl)-3,3-difluorocyclopentane-1-carboxamide (67);

N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-N-((4-(3-(cyclopropylmethyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (68);

N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-N-((4-(3-(cyclopropylmethyl)-1,2,4-N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-N-((4-(3-(cyclopropylmethyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3,3-difluorocyclopentane-1-carboxamide (69);

N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-N-((4-(3-(cyclopropylmethyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3,3-difluorocyclobutane-1-carboxamide (70);

N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-N-((4-(3-(cyclopropylmethyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)cyclobutanecarboxamide (71);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-(methoxymethyl)thiazol-4-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (72);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-(difluoromethyl)-N-(3-(2-(methoxymethyl)thiazol-4-yl)phenyl)cyclobutane-1-carboxamide (73);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3,3-difluoro-N-(3-(2-(methoxymethyl)thiazol-4-yl)phenyl)cyclopentane-1-carboxamide (74);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-cyclopropyl-1-methyl-1H-pyrazol-3-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (75);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-cyclopropyl-1-methyl-1H-pyrazol-3-yl)phenyl)-3,3-difluorocyclobutane-1-carboxamide (76);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-cyclopropyl-1-methyl-1H-pyrazol-3-yl)phenyl)-3,3-difluorocyclopentane-1-carboxamide (77);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-cyclopropyl-1-methyl-1H-pyrazol-3-yl)phenyl)-3-(difluoromethyl)cyclobutane-1-carboxamide (78);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(4-(2-methoxypropan-2-yl)oxazol-2-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (79);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(3-ethyl-2-oxo-2,3-dihydrooxazol-5-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (80);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(3-ethyl-2-oxo-2,3-dihydrooxazol-5-yl)phenyl)-3,3-difluorocyclobutane-1-carboxamide (81);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3,3-difluoro-N-(3-(4-(methoxymethyl)oxazol-2-yl)phenyl)cyclobutane-1-carboxamide (84);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(4-(methoxymethyl)oxazol-2-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (85);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (86);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)phenyl)-3,3-difluorocyclobutane-1-carboxamide (87);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (88);

N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-3-fluoro-N-((4-(3-isopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (89);

N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-3-fluoro-N-((4-(3-(tetrahydro-2H-pyran-4-yl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (90);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)pyrrolidine-1-carboxamide (91);

1-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-1-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-3-neopentylurea (92);

(S)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-3-(dimethylamino)pyrrolidine-1-carboxamide (93);

1-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-1-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-3-(1-methylcyclopropyl)urea (94);

1-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-1-(3-(3-1-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-1-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-3-ethylurea (95);

1-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-1-(3-(3-1-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-1-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-3-(4-methoxyphenyl)urea (96);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(5-(3-fluorobicyclo[1.1.1]pentan-1-yl)-1,2,4-oxadiazol-3-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (102);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (103);

N-(3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)phenyl)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (104);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-(difluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (105);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(5-(1-methylcyclopropyl)-1,2,4-oxadiazol-3-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (106);

N-(3-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)phenyl)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl) bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (107);

(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (108);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl) 3 -fluoro-N-(3-(5-isopropyl-1,2,4-oxadiazol-3-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (109);

(5-(1-hydroxycyclopropyl)-1,2,4-oxadiazol-3-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (110);

N-(3-(5-(1-acetamidocyclopropyl)-1,2,4-oxadiazol-3-yl)phenyl)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (111);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (112);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(5-(3-methyloxetan-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (113);

N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-3-fluoro-N-((4-(5-(3-fluorobicyclo[1.1.1]pentan-1-yl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl) bicyclo[1.1.1]pentane-1-carboxamide (114);

N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-3-fluoro-N-((4-(5-(1-methylcyclopropyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (115);

N-((4-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (116);

N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-N-((4-(5-(difluoromethyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (117);

N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-3-fluoro-N-((4-(5-(1-(trifluoromethyl) cyclopropyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (118);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (119);

N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-3-fluoro-N-((4-(5-isopropyl-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (120);

N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-N-((4-(5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (121);

N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-3-fluoro-N-((4-(5-(3-methyloxetan-3-yl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (122);

N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-N-((4-(5-(2,2-difluorocyclopropyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (123);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-cyclopropyl-1-methyl-1H-imidazol-4-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (130);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-cyclopropyl-1-methyl-1H-imidazol-4-yl)phenyl)-3,3-difluorocyclobutane-1-carboxamide (131);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-cyclopropyl-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (132);

N-((4-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)phenyl)-3,3-difluorocyclopentane-1-carboxamide (133);

N-((4-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)phenyl)-3-(difluoromethyl)cyclobutane-1-carboxamide (134);

N-((4-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)phenyl)-3,3-difluorocyclobutane-1-carboxamide (135);

N-((4-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (136);

N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-N-((4-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (137);

N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-N-((4-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3,3-difluorocyclobutane-1-carboxamide (138);

N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-N-((4-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-(difluoromethyl)cyclobutane-1-carboxamide (139);

(5-(1-methoxycyclopropyl)-1,2,4-oxadiazol-3-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (147);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(1-(oxetan-3-yl)-1H-pyrazol-3-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (149);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(1-(oxetan-3-yl)-1H-pyrazol-4-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (150);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(4-methylthiazol-2-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (151);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(1-(pyridin-3-yl)-1H-pyrazol-4-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (152);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (153);

N-(3-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)phenyl)-3-fluoro-N-((4-(5-(1-methylcyclopropyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl) bicyclo[1.1.1]pentane-1-carboxamide (154);

N-(3-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)phenyl)-3-fluoro-N-((4-(5-(3-methyloxetan-3-yl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (155);

N-(3-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)phenyl)-N-((4-(5-(difluoromethyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (156);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (157);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (158);

(1-(methylsulfonyl)-1H-pyrazol-4-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (159);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(1-(difluoromethyl)-1H-pyrazol-4-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (160);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(1-(2,2-difluoroethyl)-1H-pyrazol-4-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (161);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (162);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (171);

N-(3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)phenyl)-N-((4-(3-(difluoromethyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (172);

N-((4-(3-(difluoromethyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(5-(3-methyloxetan-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (173);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(5-(3-methyloxetan-3-yl)-1,2,4-oxadiazol-3-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (174);

3-fluoro-N-((4-(3-isopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-(1-methylcyclopropyl)-1,2,4-oxadiazol-3-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (175);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(5-(1-methylcyclopropyl)-1,2,4-oxadiazol-3-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (176);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(5-(1-methylcyclopropyl)-1,2,4-oxadiazol-3-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (177);

N-((4-(5-(difluoromethyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(5-(1-methylcyclopropyl)-1,2,4-oxadiazol-3-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (178);

N-((4-(5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(5-(1-methylcyclopropyl)-1,2,4-oxadiazol-3-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (179);

3-fluoro-N-(3-(5-(1-methylcyclopropyl)-1,2,4-oxadiazol-3-yl)phenyl)-N-((4-(5-(3-methyloxetan-3-yl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (180);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (183);

N-((4-(5-(difluoromethyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-(difluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (184);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-3-methyloxetane-3-carboxamide (191);

(1S,3S)-N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-3-methoxycyclobutane-1-carboxamide (192);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(3-N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-1-(2,2,2-trifluoroacetyl)azetidine-3-carboxamide (193);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(1-(methylsulfonyl)-1H-pyrazol-4-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (194);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (195);

N-((1-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-2-oxabicyclo[2.2.2]octan-4-yl)methyl)-N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (196);

N-((1-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-2-oxabicyclo[2.2.2]octan-4-yl)methyl)-N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-3,3-difluorocyclobutane-1-carboxamide (197);

N-((1-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-2-oxabicyclo[2.2.2]octan-4-yl)methyl)-N-(3-(3-N-((1-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-2-oxabicyclo[2.2.2]octan-4-yl)methyl)-N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-3-(difluoromethyl)cyclobutane-1-carboxamide (198);

N-((1-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-2-oxabicyclo[2.2.2]octan-4-yl)methyl)-N-(3-(5-cyclopropylisoxazol-3-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (199);

N-((1-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-2-oxabicyclo[2.2.2]octan-4-yl)methyl)-N-(3-(5-N-((1-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-2-oxabicyclo[2.2.2]octan-4-yl)methyl)-N-(3-(5-cyclopropylisoxazol-3-yl)phenyl)-3,3-difluorocyclobutane-1-carboxamide (200);

N-((1-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-2-oxabicyclo[2.2.2]octan-4-yl)methyl)-N-(3-(5-N-((1-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-2-oxabicyclo[2.2.2]octan-4-yl)methyl)-N-(3-(5-cyclopropylisoxazol-3-yl)phenyl)-3-(difluoromethyl)cyclobutane-1-carboxamide (201);

N-((1-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-2-oxabicyclo[2.2.2]octan-4-yl)methyl)-N-(3-(5-cyclopropylisoxazol-3-yl)phenyl)-3,3-difluorocyclopentane-1-carboxamide (202);

N-((1-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-2-oxabicyclo[2.2.2]octan-4-yl)methyl)-N-(3-(5-cyclopropylisoxazol-3-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (203);

N-((1-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-2-oxabicyclo[2.2.2]octan-4-yl)methyl)-N-(3-(5-(difluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (204);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(5-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)pyridin-3-yl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (206);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(5-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)pyridin-3-yl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (207);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)-2-oxabicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (208);

N-(3-(1H-pyrazol-4-yl)phenyl)-3-fluoro-N-((4-(5-(1-(trifluoromethyl)cyclopropyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (209);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)pyridin-2-yl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (210);

N-(4-(1H-pyrazol-4-yl)pyridin-2-yl)-N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl) bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (211);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(4-(1-(difluoromethyl)-1H-pyrazol-4-yl)pyridin-2-yl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (212);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(3-(tert-butyl)-1-methyl-1H-pyrazol-5-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (213);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-(tert-butyl)-1-methyl-1H-pyrazol-3-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (214);

N-(1-(4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)ethyl)-N-(3-(2-cyclopropyloxazol-5-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (215-216);

N-(1-(4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)ethyl)-N-(3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (217-218);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(4-cyclopropyl-1H-1,2,3-triazol-1-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (219);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(4-ethoxypyridin-2-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (225);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-ethoxypyridin-4-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (226);

3-Fluoro-N-(3-(2-methoxypyridin-4-yl)phenyl)-N-((4-(3-(tetrahydro-2H-pyran-4-yl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (227);

3-fluoro-N-(3-(2-methoxypyridin-4-yl)phenyl)-N-((4-(3-methyl-1,2,4-oxadiazol-5-yl) bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (228);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-methoxypyridin-4-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (229);

3-Fluoro-N-(3-(2-methoxypyridin-4-yl)phenyl)-N-((4-(5-methyl-1,3,4-oxadiazol-2-yl) bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1] pentane-1-carboxamide (230);

N-(3-(2-methoxypyridin-4-yl)phenyl)-N-((4-(5-methyl-1,3,4-oxadiazol-2-yl) bicyclo[2.2.2]octan-1-yl)methyl)cyclobutanecarboxamide (231);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-methoxypyrimidin-4-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (242);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3,3-difluoro-N-(3-(2-methoxypyrimidin-4-yl)phenyl)cyclobutane-1-carboxamide (243);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-methoxypyrimidin-4-yl)phenyl)cyclobutanecarboxamide (244);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3,3-difluoro-N-(3-(2-methoxypyrimidin-4-yl)phenyl)cyclopentane-1-carboxamide (245);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(6-fluoro-5-methylpyridin-3-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (247);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-methoxypyrimidin-5-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (248);

(6-methoxypyridin-3-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (249);

N-(3-(benzo[d][1,3]dioxol-5-yl)phenyl)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl) bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (255);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (261);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-(trifluoromethyl)pyrimidin-5-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (262);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(8-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (263);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (264);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (265);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (266);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(6-(methylsulfonamido)pyridin-3-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (270);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-cyclopropylpyrimidin-5-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (271);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-(methylsulfonamido)pyrimidin-5-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (272);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(6-(methoxymethyl)pyridin-3-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (274);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-methylbenzo[d]oxazol-6-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (275);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-cyclopropylthiazolo[4,5-b]pyridin-6-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (276);

N-(3-(benzo[d]thiazol-6-yl)phenyl)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl) bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (277);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-methylthiazolo[4,5-b]pyridin-6-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (278);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (280);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(6-ethoxypyridin-3-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (281);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(6-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(6-ethoxypyridazin-3-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (283);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (284);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(5-fluoropyridin-2-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (287);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(imidazo[1,2-a]pyridin-7-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (288);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-ethoxypyrimidin-5-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (289);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(4-(trifluoromethyl)pyrimidin-2-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (291);

N-(3-(6-cyanopyridin-2-yl)phenyl)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl) bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (292);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(3-fluoro-6-(trifluoromethyl)pyridin-2-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (293);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(6-methylpyridazin-3-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (295);

N-(3-(5-cyanopyridin-2-yl)phenyl)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl) bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (297);

N-(3-([1,2,4]triazolo[1,5-a]pyridin-7-yl)phenyl)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl) bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (298);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(4-methylpyrimidin-2-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (300);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-methylbenzo[d]thiazol-5-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (303);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(1-methyl-1H-indazol-5-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (304);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-methylbenzo[d]oxazol-5-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (305);

N-(3-(3-cyanoimidazo[1,2-b]pyridazin-6-yl)phenyl)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (306);

N-(3-([1,2,4]triazolo[4,3-a]pyridin-7-yl)phenyl)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl) bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (307);

N-(3-([1,2,4]triazolo[1,5-a]pyridin-8-yl)phenyl)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl) bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (309);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(5-methylpyrazin-2-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (310);

N-(3-(8-cyanoquinolin-5-yl)phenyl)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl) bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (311);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (312);

N-(3-(5-cyano-1-methyl-1H-pyrazolo[3,4-b]pyridin-6-yl)phenyl)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (313);

N-(3-(7-cyanoimidazo[1,2-b]pyridazin-3-yl)phenyl)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (314);

N-(3-(2-chloropyrrolo[2,1-f][1,2,4]triazin-4-yl)phenyl)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (315);

N-(3-(6-cyanothieno[3,2-b]pyridin-5-yl)phenyl)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl) bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (316);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(8-fluoroimidazo[1,2-a]pyridin-6-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (317);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(imidazo[1,2-b]pyridazin-3-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide(318);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(7-methylimidazo[1,2-b]pyridazin-3-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (319);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2,7-dimethylimidazo[1,2-a]pyridin-6-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (320);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-methyl-8-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (321);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2,8-dimethylimidazo[1,2-a]pyridin-6-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (322);

N-(3-([1,2,4]triazolo[4,3-a]pyridin-6-yl)phenyl)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl) bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (323);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (324);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(5-methylpyridin-2-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (325);

N-(3-(6-bromo-[1,2,4]triazolo[1,5-a]pyridin-8-yl)phenyl)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (326);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(7-methylthiazolo[5,4-b]pyridin-5-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (327);

N-(3-(3-cyano-7,8-dihydro-5H-pyrano[4,3-b]pyridin-2-yl)phenyl)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (328);

N-(3-(7-chloroimidazo[1,2-b]pyridazin-3-yl)phenyl)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (329);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(imidazo[1,2-a]pyridin-8-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (330);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-hydroxyquinolin-6-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (331);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-oxoindolin-5-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (332);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-ethoxypyrimidin-2-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (333);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(5-methoxypyrimidin-2-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (334);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-(difluoromethoxy)pyrimidin-2-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (335);

N-(3-(2-acetamidoimidazo[1,2-b]pyridazin-6-yl)phenyl)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (336);

N-(3-(2-cyclopropoxypyrimidin-4-yl)phenyl)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl) bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (337);

N-(3-(2-cyclopropoxypyrimidin-4-yl)phenyl)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl) N-(3-(2-cyclopropoxypyrimidin-4-yl)phenyl)-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl) bicyclo[2.2.2]octan-1-yl)methyl)-3,3-difluorocyclobutane-1-carboxamide (338);

N-((1-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-2-oxabicyclo[2.2.2]octan-4-yl)methyl)-3-fluoro-N-(3-(2-methoxypyridin-4-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (339);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(2′-methoxy-[4,4′-bipyridin]-2-yl)bicyclo[1.1.1]pentane-1-carboxamide (340);

N-((4-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-methoxypyrimidin-5-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (341);

N-((4-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-N-((4-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-methoxypyridin-4-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (342);

N-((4-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-N-((4-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(6-methoxypyridin-3-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (343);

N-((1-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-2-oxabicyclo[2.2.2]octan-4-yl)methyl)-N-(3-(2-ethoxypyrimidin-5-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (353);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-ethoxypyrimidin-5-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (357);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-cyclopropylpyrimidin-5-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (358);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(6-ethoxypyridin-3-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (360);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-methylbenzo[d]thiazol-6-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (362);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-methoxypyrimidin-5-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (363);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(6-(methylsulfonamido)pyridin-3-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (364);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-methylthiazolo[4,5-b]pyridin-6-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (365);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-(trifluoromethyl)pyrimidin-5-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (366);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-(methylsulfonamido)pyrimidin-5-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (367);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(5-methoxypyrimidin-2-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (369);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-ethoxypyrimidin-2-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (370);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-(difluoromethoxy)pyrimidin-2-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (371);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-(difluoromethoxy)pyridin-2-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (373);

N-(3-(2-ethoxypyrimidin-5-yl)phenyl)-3-fluoro-N-((4-(3-isopropyl-1,2,4-oxadiazol-5-yl) bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (374);

3-fluoro-N-((4-(3-isopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-methylbenzo[d]thiazol-6-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (378);

N-(3-(6-ethoxypyridin-3-yl)phenyl)-3-fluoro-N-((4-(3-isopropyl-1,2,4-oxadiazol-5-yl) bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (381);

3-fluoro-N-((4-(3-isopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(6-methoxypyridin-3-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (382);

3-Fluoro-N-((4-(3-isopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-methoxypyrimidin-5-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (383);

3-fluoro-N-((4-(3-isopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-(trifluoromethyl)pyrimidin-5-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (384);

N-(3-(2-cyclopropylpyrimidin-5-yl)phenyl)-3-fluoro-N-((4-(3-isopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (385);

N-(3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)phenyl)-3-fluoro-N-((4-(3-isopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (386);

3-fluoro-N-((4-(3-isopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(6-(trifluoromethyl)pyridin-3-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (388);

3-fluoro-N-((4-(3-isopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-methylthiazolo[4,5-b]pyridin-6-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (389);

3-fluoro-N-((4-(3-isopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-methylpyrimidin-2-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (391);

3-fluoro-N-((4-(3-isopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-3-fluoro-N-((4-(3-isopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-methylpyrimidin-2-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (393);

N-(3-(5-ethylpyrimidin-2-yl)phenyl)-3-fluoro-N-((4-(3-isopropyl-1,2,4-oxadiazol-5-yl) bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (394);

N-(3-(5-ethylpyrimidin-2-yl)phenyl)-3-fluoro-N-((4-(3-isopropyl-1,2,4-oxadiazol-5-yl) bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (395);

N-(3-(2-ethoxypyrimidin-5-yl)phenyl)-3-fluoro-N-((4-(5-(1-methylcyclopropyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (396);

3-fluoro-N-(3-(2-methoxypyrimidin-5-yl)phenyl)-N-((4-(5-(1-methylcyclopropyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (400);

N-(3-(6-ethoxypyridin-3-yl)phenyl)-3-fluoro-N-((4-(5-(1-methylcyclopropyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide(401);

3-fluoro-N-(3-(2-methylbenzo[d]thiazol-6-yl)phenyl)-N-((4-(5-(1-methylcyclopropyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (402);

N-(3-(2-cyclopropylpyrimidin-5-yl)phenyl)-3-fluoro-N-((4-(5-(1-methylcyclopropyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (403);

3-fluoro-N-((4-(5-(1-methylcyclopropyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl) methyl)-N-(3-(2-(trifluoromethyl)pyrimidin-5-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (404);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(4-methylpiperazin-1-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (416);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-morpholinophenyl)bicyclo[1.1.1]pentane-1-carboxamide (417);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(5-(2-ethoxypyrimidin-5-yl)pyridin-3-yl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (423);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(5-(2-methylbenzo[d]thiazol-6-yl)pyridin-3-yl)bicyclo[1.1.1]pentane-1-carboxamide (425);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(6′-ethoxy-[3,3′-bipyridin]-5-yl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (426);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(5-(2-(trifluoromethyl)pyrimidin-5-yl)pyridin-3-yl)bicyclo[1.1.1]pentane-1-carboxamide (428);

N-(3-(2-ethoxypyrimidin-5-yl)phenyl)-3-fluoro-N-((4-(5-isopropyl-1,2,4-oxadiazol-3-yl) bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (429);

N-(3-(6-ethoxypyridin-3-yl)phenyl)-3-fluoro-N-((4-(5-isopropyl-1,2,4-oxadiazol-3-yl) bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (432);

3-fluoro-N-((4-(5-isopropyl-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-methylbenzo[d]thiazol-6-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (433);

N-(3-(2-cyclopropylpyrimidin-5-yl)phenyl)-3-fluoro-N-((4-(5-isopropyl-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (434);

3-fluoro-N-((4-(5-isopropyl-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-(trifluoromethyl)pyrimidin-5-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (435);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-ethoxypyrimidin-5-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (437);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(6-ethoxypyridin-3-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (440);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-methylbenzo[d]thiazol-6-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (441);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-cyclopropylpyrimidin-5-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (442);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-(trifluoromethyl)pyrimidin-5-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (443);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (447);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-methylthiazolo[4,5-b]pyridin-6-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (449);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(5-methoxypyrimidin-2-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (450);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-ethoxypyrimidin-2-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (451);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-(difluoromethoxy)pyrimidin-2-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (452);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-ethylpyrimidin-2-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (453);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(5-methylpyrimidin-2-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (454);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(5-(difluoromethoxy)pyridin-2-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (455);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (457);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-cyclopropylthiazolo[4,5-b]pyridin-6-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (458);

N-((4-(5-(difluoromethyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-ethoxypyrimidin-5-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (459);

N-((4-(5-(difluoromethyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-methylbenzo[d]thiazol-6-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (462);

bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (463);

N-((4-(5-(difluoromethyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-(trifluoromethyl)pyrimidin-5-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (464);

N-(3-(2-cyclopropylpyrimidin-5-yl)phenyl)-N-((4-(3-(difluoromethyl)-1,2,4-oxadiazol-5-yl) bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (466);

N-((4-(3-(difluoromethyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-(trifluoromethyl)pyrimidin-5-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide(467);

N-((4-(3-(difluoromethyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-ethoxypyrimidin-5-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (470);

N-((4-(3-(difluoromethyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-methylbenzo[d]thiazol-6-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (471);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(5-(2-ethoxypyrimidin-5-yl)pyridin-3-yl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (472);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(5-(2-cyclopropylpyrimidin-5-yl)pyridin-3-yl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (473);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(5-(2-methylbenzo[d]thiazol-6-yl)pyridin-3-yl)bicyclo[1.1.1]pentane-1-carboxamide (474);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(6′-ethoxy-[3,3′-bipyridin]-5-yl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (477);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(5-(2-ethoxypyrimidin-5-yl)pyridin-3-yl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (478);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(5-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)pyridin-3-yl)bicyclo[1.1.1]pentane-1-carboxamide (479);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(5-(2-cyclopropylthiazolo[4,5-b]pyridin-6-yl)pyridin-3-yl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (480);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(5-(2-N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(5-(2-methylbenzo[d]thiazol-6-yl)pyridin-3-yl)bicyclo[1.1.1]pentane-1-carboxamide (484);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(5-(5-(difluoromethoxy)pyrimidin-2-yl)pyridin-3-yl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (485);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(5-N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(5-(difluoromethoxy)-[2,3′-bipyridin]-5′-yl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (486);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-ethoxypyrimidin-5-yl)phenyl)-3-hydroxycyclobutane-1-carboxamide (501);

(1S,3S)-N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-ethoxypyrimidin-5-yl)phenyl)-3-methoxycyclobutane-1-carboxamide (502);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-ethoxypyrimidin-5-yl)phenyl)-3-methyloxetane-3-carboxamide (503);

(1S,3S)-N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-ethoxypyrimidin-5-yl)phenyl)-3-hydroxy-3-methylcyclobutane-1-carboxamide (504);

tert-butyl (3-(((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)(3-(2-ethoxypyrimidin-5-yl)phenyl)carbamoyl)bicyclo[1.1.1]pentan-1-yl)carbamate (505);

3-amino-N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-ethoxypyrimidin-5-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (506);

(1S,3S)-N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-ethoxypyrimidin-5-yl)phenyl)-3-hydroxy-3-(trifluoromethyl)cyclobutane-1-carboxamide (507);

(cis)-N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-ethoxypyrimidin-5-yl)phenyl)-3-hydroxy-3-methylcyclobutane-1-carboxamide (508);

(1S,3S)-N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-ethoxypyrimidin-5-yl)phenyl)-3-hydroxy-3-(trifluoromethyl)cyclobutane-1-carboxamide (509);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-ethoxypyrimidin-5-yl)phenyl)-3-methyloxetane-3-carboxamide (510);

(1S,3S)-N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-ethoxypyrimidin-5-yl)phenyl)-3-methoxycyclobutane-1-carboxamide (511);

(cis)-N-(3-(2-ethoxypyrimidin-5-yl)phenyl)-3-methoxy-N-((4-(5-(3-methyloxetan-3-yl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)cyclobutane-1-carboxamide (518);

(1S,3S)-N-(3-(2-ethoxypyrimidin-5-yl)phenyl)-3-hydroxy-3-methyl-N-((4-(5-(3-methyloxetan-3-yl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)cyclobutane-1-carboxamide (519);

(1S,3S)-N-(3-(2-ethoxypyrimidin-5-yl)phenyl)-3-hydroxy-N-((4-(5-(3-methyloxetan-3-yl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-(trifluoromethyl)cyclobutane-1-carboxamide (520);

3-fluoro-N-(3-(2-methylbenzo[d]thiazol-6-yl)phenyl)-N-((4-(5-(1-(trifluoromethyl) cyclopropyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (524);

N-(3-(2-ethoxypyrimidin-5-yl)phenyl)-3-fluoro-N-((4-(5-(1-(trifluoromethyl)cyclopropyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (525);

N-(3-(2-cyclopropylthiazolo[4,5-b]pyridin-6-yl)phenyl)-3-fluoro-N-((4-(5-(1-(trifluoromethyl)cyclopropyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl) bicyclo[1.1.1]pentane-1-carboxamide (526);

N-((4-(5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-ethoxypyrimidin-5-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (529);

N-(3-(2-cyclopropylthiazolo[4,5-b]pyridin-6-yl)phenyl)-N-((4-(5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (530);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(4-(2-ethoxypyrimidin-5-yl)pyridin-2-yl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (531);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(4-(2-cyclopropylthiazolo[4,5-b]pyridin-6-yl)pyridin-2-yl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (535);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(6-ethoxy-[3,4′-bipyridin]-2′-yl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (536);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(4-(2-methylbenzo[d]thiazol-6-yl)pyridin-2-yl)bicyclo[1.1.1]pentane-1-carboxamide (537);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(4-(2-N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(4-(2-methoxypyrimidin-5-yl)pyridin-2-yl)bicyclo[1.1.1]pentane-1-carboxamide (538);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(4-(2-cyclopropylpyrimidin-5-yl)pyridin-2-yl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (539);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(4-(2-N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(4-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)pyridin-2-yl)bicyclo[1.1.1]pentane-1-carboxamide (540);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(4-(5-(difluoromethoxy)pyrimidin-2-yl)pyridin-2-yl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (541);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(4-(5-ethoxypyrimidin-2-yl)pyridin-2-yl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (542);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(4-(5-ethylpyrimidin-2-yl)pyridin-2-yl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (543);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(5-(difluoromethoxy)-[2,4′-bipyridin]-2′-yl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (544);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(4-(2-ethoxypyrimidin-5-yl)pyridin-2-yl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (548);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(4-(2-methylbenzo[d]thiazol-6-yl)pyridin-2-yl)bicyclo[1.1.1]pentane-1-carboxamide (549);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(4-N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(4-(2-methylbenzo[d]oxazol-6-yl)pyridin-2-yl)bicyclo[1.1.1]pentane-1-carboxamide (550);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(4-(2-methylbenzo[d]thiazol-6-yl)pyridin-2-yl)bicyclo[1.1.1]pentane-1-carboxamide (551);

N-((4-(3-(tert-butyl)-1,2,4-oxadiazol-5-yl)-2-oxabicyclo[2.2.2]octan-1-yl)methyl)-N-(3-(2-ethoxypyrimidin-5-yl)phenyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (553);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3,3-difluoro-N-(3-(2-methylbenzo[d]thiazol-6-yl)phenyl)cyclobutane-1-carboxamide (554);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-methylbenzo[d]thiazol-6-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (555);

N-((4-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(5-fluorobenzo[d]oxazol-2-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (559);

N-((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3,3-difluoro-N-(3-(5-fluorobenzo[d]oxazol-2-yl)phenyl)cyclobutane-1-carboxamide (560);

N-((4-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(2-methylbenzo[d]thiazol-6-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (561);

N-((4-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-(difluoromethyl)-N-(3-(2-methylbenzo[d]thiazol-6-yl)phenyl)cyclobutane-1-carboxamide (562);

N-((4-(5-cyclopropyl-1,3,4-oxadiazol-2-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3,3-difluoro-N-(3-(2-methylbenzo[d]thiazol-6-yl)phenyl)cyclopentane-1-carboxamide (563);

N-((1-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-2-oxabicyclo[2.2.2]octan-4-yl)methyl)-3-fluoro-N-(3-(2-methylbenzo[d]thiazol-6-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (564);

N-((1-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-2-oxabicyclo[2.2.2]octan-4-yl)methyl)-3,3-difluoro-N-(3-(2-methylbenzo[d]thiazol-6-yl)phenyl)cyclobutane-1-carboxamide (565);

N-((1-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-2-oxabicyclo[2.2.2]octan-4-yl)methyl)-3-(difluoromethyl)-N-(3-(2-methylbenzo[d]thiazol-6-yl)phenyl)cyclobutane-1-carboxamide (566);

N-((1-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-2-oxabicyclo[2.2.2]octan-4-yl)methyl)-3,3-difluoro-N-(3-(2-methylbenzo[d]thiazol-6-yl)phenyl)cyclopentane-1-carboxamide (567);

N-(3-cyclopropylphenyl)-N-((4-(5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl) bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (571);

N-(3-cyclopropylphenyl)-3-fluoro-N-((4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl) bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (572):

N-(3-cyclopropylphenyl)-3-fluoro-N-((4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl) bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (573);

N-(3-cyclopropyl-4-fluorophenyl)-N-((4-(5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl) bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (574);

N-(3-(azetidin-1-yl)-4-fluorophenyl)-N-((4-(5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl) bicyclo[2.2.2]octan-1-yl)methyl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (575);

N-(3-(2-cyclopropylpyrimidin-5-yl)phenyl)-3-fluoro-N-((4-(5-(1-fluorocyclopropyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (579);

N-(3-(2-cyclopropylpyrimidin-5-yl)phenyl)-3-fluoro-N-((4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)bicyclo[1.1.1]pentane-1-carboxamide (580);

N-((4-(5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-fluoro-N-(3-(4-hydroxypiperidin-1-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (589);

(cis)-N-((4-(5-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-hydroxy-N-(3-(6-(2-hydroxypropan-2-yl)spiro[3.3]hept-1-en-2-yl)phenyl)-3-(trifluoromethyl) cyclobutane-1-carboxamide (590);

(cis)-N-(3-(2-oxa-6-azaspiro[3.3]heptan-6-yl)phenyl)-N-((4-(5-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-hydroxy-3-(trifluoromethyl)cyclobutane-1-carboxamide (592);

(cis)-N-((4-(5-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-3-hydroxy-N-(3-(6-(2-hydroxypropan-2-yl)pyridazin-3-yl)phenyl)-3-(trifluoromethyl)cyclobutane-1-carboxamide (593);

3-fluoro-N-((4-(5-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl) methyl)-N-(3-(6-oxo-1,6-dihydropyridazin-4-yl)phenyl)bicyclo[1.1.1]pentane-1-carboxamide (594);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(2-(2-ethoxypyrimidin-5-yl)pyridin-4-yl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (596);

N-((4-(5-(tert-butyl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl)methyl)-N-(2-(2-cyclopropylpyrimidin-5-yl)pyridin-4-yl)-3-fluorobicyclo[1.1.1]pentane-1-carboxamide (597);

1,1,1-trifluoro-2-methylpropan-2-yl(5-fluoro-4-(1-(oxetan-3-ylmethyl)-1H-pyrazol-4-yl) pyridin-2-yl)((4-(5-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl) methyl)carbamate (621);

3-(bicyclo[1.1.1]pentan-1-yl)-1-((4-(5-(1,1-difluoroethyl)-1,2,4-oxadiazol-3-yl) bicyclo[2.2.2]octan-1-yl)methyl)-1-(4-fluoro-3-(1-(2-hydroxy-2-methylpropyl)-1H-pyrazol-4-yl)phenyl)urea (633);

3-fluoro-N-((4-(5-(2-fluoropropan-2-yl)-1,2,4-oxadiazol-3-yl)bicyclo[2.2.2]octan-1-yl) methyl)-N-(3-(1-(2-hydroxy-2-methylpropyl)-1,2,3,6-tetrahydropyridin-4-yl)phenyl) bicyclo [1.1.1] pentane-1-carboxamide (663);

1,1,1-trifluoro-2-methylpropan-2-yl (4-(4-cyanobicyclo[2.2.2]octan-1-yl)pyrimidin-2-yl)((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)carbamate (665);

methyl 4-(2-(((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl) (((1,1,1-trifluoro-2-methylpropan-2-yl) oxy)carbonyl)amino)pyrimidin-4-yl)bicyclo [2.2.2]octane-1-carboxylate (665E);

4-(2-(((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl) bicyclo[2.2.2]octan-1-yl)methyl)(((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl) amino)pyrimidin-4-yl)bicyclo[2.2.2]octane-1-carboxylic acid (665F); or

1,1,1-trifluoro-2-methylpropan-2-yl (4-(4-carbamoylbicyclo[2.2.2]octan-1-yl)pyrimidin-2-yl)((4-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)bicyclo[2.2.2]octan-1-yl)methyl)carbamate (665G).