Composition for improving, preventing or treating skin diseases comprising induced pluripotent stem cell-derived mesenchymal stem cell and exosome derived therefrom
View Patent ↗The present invention may provide a pharmaceutical composition for preventing or treating skin diseases, a cosmetic composition for preventing or improving skin diseases, and a stem cell therapeutic agent, which comprise an induced pluripotent stem cell-derived mesenchymal stem cell (iMSC), a culture thereof, or an exosome isolated from an iMSC or iMSC culture as active ingredients. When the composition of the present invention, etc. is used, it is possible to provide a composition for improving, preventing or treating skin diseases and a stem cell therapeutic agent which have an improved immunomodulating function over conventional mesenchymal stem cells.
1. A method for treating or alleviating a skin disease in a subject in need thereof, comprising:
administering to the subject a composition comprising an effective amount of one or more exosomes isolated from induced pluripotent stem cell-derived mesenchymal stem cells or a culture thereof,
wherein the skin disease is selected from the group consisting of atopic dermatitis and contact dermatitis.
2. The method of claim 1 , wherein the subject is a mammal or a human.