IP Library Granted Patent US 11,731,978
Granted Patent B2
US 11,731,978 · App. 17/702,518 · Granted Aug 22, 2023

3-(ethoxydifluoromethyl)-6-(5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-[1,2,4]triazolo[4,3-a]pyridine as an ion channel modulator

Inventors: Andrew Mark Griffin (L'lle Bizard, CA); Brian Edward Marron (Ada, MI); Gabriel Martinez Botella (Wayland, MA)
Assignee: PRAXIS PRECISION MEDICINES, INC.
C07D487/04A61P23/00A61P25/08C07D471/04C07B2200/13
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 11,731,978
App. No.
17/702,518
Granted
Aug 22, 2023
Kind
B2
Abstract

The present invention is directed to 3-(ethoxydifluoromethyl)-6-(5-fluoro-6-(2,2,2-trofluoroethoxy)pyridine-3-yl)-[1,2,4]triazolo[4,3-α]pyridine, or a pharmaceutically acceptable salt thereof, or a composition thereof, which is useful for preventing and/or treating a disease or condition relating to aberrant function of a voltage-gated, sodium ion channel, for example, abnormal late/persistent sodium current. Methods of treating a disease or condition relating to aberrant function of a sodium ion channel including neurological disorders (e.g., Dravet syndrome, epilepsy), pain, and neuromuscular disorders are also provided herein.

Claims (6)

1. The compound:

or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and the compound:

or a pharmaceutically acceptable salt thereof.

3. The compound:

4. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and the compound:

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 16, 2023
From: GRIFFIN, ANDREW MARK; MARRON, BRIAN EDWARD; MARTINEZ BOTELLA, GABRIEL
To: PRAXIS PRECISION MEDICINES, INC.
Reel/Frame 063972/0240 →
Continuity (6)
Continuation 17214343 · Mar 26, 2021
Continuation 17102586 · Nov 24, 2020
Continuation PCTUS2019034653 · May 30, 2019
Provisional Application 62738508 · Sep 28, 2018
Provisional Application 62677903 · May 30, 2018
Related Publication 20220220118A1 · Jul 14, 2022
Cited By (2)
US 12,325,711 US 12,582,652