IP Library › Granted Patent US 11,733,440
Granted Patent B1
US 11,733,440 · App. 17/661,109 · Granted Aug 22, 2023

Thermally stable nanoparticles and methods thereof

Inventors: Frank Gu (Toronto, CA); Aaron Joshua Clasky (Toronto, CA)
Assignee: Johnson & Johnson Vision Care, Inc.
G02B5/206C08K3/08C08L39/06B82Y20/00B82Y40/00C08K2003/0831C08K2201/011G02B2207/101
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Quick Facts
Patent No.
US 11,733,440
App. No.
17/661,109
Granted
Aug 22, 2023
Kind
B1
Abstract

A composition for light filtering, the composition comprising: a base material; a plurality of nanoparticles dispersed in the base material, wherein at least a portion of the plurality of nanoparticles have an anisotropic shape; a stabilizing mechanism disposed to selectively couple with at least a portion of the plurality of nanoparticles to enhance stability of at least the portion of the plurality of nanoparticles in the base material, wherein a molecular weight of the stabilizing mechanism is selected to control thermal reshaping of the anisotropic shape of at least the portion of the plurality of nanoparticles; and wherein the composition exhibits a peak light absorption value in the range of about 600 nm to about 1000 nm, and wherein the composition exhibits an absorption spectrum having a full-width at half maximum of about 58 nm-70 nm.

Claims (51)

1. A composition for light filtering, the composition comprising:

a base material;

a plurality of nanoparticles dispersed in the base material, wherein at least a portion of the plurality of nanoparticles have an anisotropic shape;

a stabilizing mechanism disposed to selectively couple with at least a portion of the plurality of nanoparticles to enhance stability of at least the portion of the plurality of nanoparticles in the base material, wherein a molecular weight of the stabilizing mechanism is selected to control thermal reshaping of the anisotropic shape of at least the portion of the plurality of nanoparticles, wherein the stabilizing mechanism is molecular weight of 55 kDa up to 1300 kDa poly(vinyl pyrrolidone); wherein the base material comprises a biomaterial, a biomaterial matrix, hydrogel; and

wherein the composition exhibits a peak light absorption value in the range of about 600 nm to about 1000 nm, and

wherein the composition exhibits an absorption spectrum having a full-width at half maximum (FWHM) of about 58 nm-70 nm.

2. The composition according to claim 1 , wherein an article formed from the composition exhibits stability after autoclaving.

3. The composition according to claim 1 , wherein the base material is the biomaterial.

4. The composition according to claim 1 , wherein the base material is the biomaterial matrix.

5. The composition according to claim 1 , wherein the base material is the hydrogel.

6. The composition according to claim 1 , wherein the at least a portion of the plurality of nanoparticles have a bipyramid shape.

7. The composition according to claim 6 , wherein a sharpness of the bipyramid shape is tuned such that the composition exhibits a peak light absorption in the range of about 600 nm to about 1000 nm.

8. The composition according to claim 1 , wherein the at least a portion of the plurality of nanoparticles have with each a pair of opposing truncated peaks disposed on opposing ends.

9. The composition of according to claim 8 , wherein a sharpness of the bipyramid shape is tuned such that the composition a peak light absorption in the range of about 600 nm to about 1000 nm.

10. The composition according to claim 1 , wherein the stabilizing mechanism is the 55 kDa poly(vinyl pyrrolidone).

11. The composition according to claim 1 , wherein the stabilizing mechanism is the 360 kDa poly(vinyl pyrrolidone).

12. The composition according to claim 1 , wherein the stabilizing mechanism is the 1300 kDa poly(vinyl pyrrolidone).

13. The composition according to claim 1 , wherein the stabilizing mechanism enhances colloidal stability, thermal stability, or both of the at least the portion of the plurality of nanoparticles in the base material.

14. The composition according to claim 1 , wherein the stabilizing mechanism enhances biocompatibility of the at least the portion of the plurality of nanoparticles in the base material.

15. The composition according to claim 1 , wherein the stabilizing mechanism chemically binds with the at least a portion of the plurality of nanoparticles to enhance stability of the at least the portion of the plurality of nanoparticles in the base material.

16. The composition according to claim 15 , wherein the stabilizing mechanism enhances thermal stability.

17. The composition according to claim 15 , wherein the stabilizing mechanism enhances colloidal stability, thermal stability, or both of the at least the portion of the plurality of nanoparticles in the base material.

18. The composition according to claim 15 , wherein the stabilizing mechanism enhances biocompatibility of the at least the portion of the plurality of nanoparticles in the base material.

19. The composition according to claim 1 , wherein the nanoparticles comprise plasmonic nanoparticles.

20. The composition of according to claim 1 , wherein the nanoparticles comprise metal nanoparticles.

21. A composition for light filtering, the composition comprising:

a base material;

a plurality of gold nanoparticles dispersed in the base material, wherein at least a portion of the plurality of gold nanoparticles have an anisotropic shape;

a stabilizing mechanism disposed to selectively couple with at least a portion of the plurality of gold nanoparticles to enhance stability of at least the portion of the plurality of gold nanoparticles in the base material, wherein a molecular weight of the stabilizing mechanism is selected to control thermal reshaping of the anisotropic shape of at least the portion of the plurality of gold nanoparticles, wherein the stabilizing mechanism is molecular weight of 55 kDa up to 1300 kDa poly(vinyl pyrrolidone); wherein the base material comprises a biomaterial, a biomaterial matrix, hydrogel; and

wherein the composition exhibits a peak light absorption value in the range of about 600 nm to about 1000 nm, and

wherein the composition exhibits an absorption spectrum having a full-width at half maximum (FWHM) of about 58 nm-70 nm.

22. The composition according to claim 21 , wherein an article formed from the composition exhibits stability after autoclaving.

23. The composition according to claim 21 , wherein the base material is the biomaterial.

24. The composition according to claim 21 , wherein the base material is the biomaterial matrix.

25. The composition according to claim 21 , wherein the base material is the hydrogel.

26. The composition according to claim 21 , wherein the at least a portion of the plurality of gold nanoparticles are grown from a pentatwinned gold seed.

27. The composition according to claim 21 , wherein the at least a portion of the plurality of gold nanoparticles have a bipyramid shape.

28. The composition according to claim 27 , wherein a sharpness of the bipyramid shape is tuned such that the composition exhibits a peak light absorption in the range of about 600 nm to about 1000 nm.

29. The composition according to claim 21 , wherein the at least a portion of the plurality of gold nanoparticles have with each a pair of opposing truncated peaks disposed on opposing ends.

30. The composition according to claim 29 , wherein a sharpness of the bipyramid shape is tuned such that the composition a peak light absorption in the range of about 600 nm to about 1000 nm.

31. The composition according to claim 21 , wherein the stabilizing mechanism is the 55 kDa poly(vinyl pyrrolidone).

32. The composition according to claim 21 , wherein the stabilizing mechanism is the 360 kDa poly(vinyl pyrrolidone).

33. The composition according to claim 21 , wherein the stabilizing mechanism is the 1300 kDa poly(vinyl pyrrolidone).

34. The composition according to claim 21 , wherein the stabilizing mechanism enhances colloidal stability, thermal stability, or both of the at least the portion of the plurality of gold nanoparticles in the base material.

35. The composition according to claim 21 , wherein the stabilizing mechanism enhances biocompatibility of the at least the portion of the plurality of gold nanoparticles in the base material.

36. The composition according to claim 21 , wherein the stabilizing mechanism chemically binds with the at least a portion of the plurality of gold nanoparticles to enhance stability of the at least the portion of the plurality of gold nanoparticles in the base material.

37. The composition according to claim 36 , wherein the stabilizing mechanism enhances thermal stability.

38. The composition according to claim 36 , wherein the stabilizing mechanism enhances colloidal stability, thermal stability, or both of the at least the portion of the plurality of gold nanoparticles in the base material.

39. The composition according to claim 36 , wherein the stabilizing mechanism enhances biocompatibility of the at least the portion of the plurality of gold nanoparticles in the base material.

40. A method of making the composition according to claim 21 .

41. The method according to claim 40 , wherein the at least a portion of the plurality of gold nanoparticles are grown from a pentatwinned gold seed.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 16, 2022
From: CLASKY, AARON; GU, FRANK
To: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
Reel/Frame 061116/0685 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 16, 2022
From: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
To: JOHNSON & JOHNSON VISION CARE, INC.
Reel/Frame 061116/0761 →
Cited By (2)
US 12,498,590 US 12,509,583