IP Library › Granted Patent US 12,509,583
Granted Patent B2
US 12,509,583 · App. 17/661,107 · Granted Dec 30, 2025

Particle surface modification to increase compatibility and stability in hydrogels

Inventors: Frank Gu (Toronto, CA); Aaron Joshua Clasky (Toronto, CA)
Assignee: Johnson & Johnson Vision Care, Inc.
C08L83/04G02C7/10C08L2203/02
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Quick Facts
Patent No.
US 12,509,583
App. No.
17/661,107
Granted
Dec 30, 2025
Kind
B2
Abstract

A composition for light filtering, the composition comprising a base material; a plurality of metal nanoparticles dispersed in the base material; a stabilizing mechanism disposed to selectively couple with at least a portion of the plurality of metal nanoparticles to enhance stability of at least the portion of the plurality of metal nanoparticles in the base material; and an anchoring mechanism disposed to promote chemical conjugation of at least a portion of the plurality of metal nanoparticles to the base material, wherein the composition exhibits a peak light filtering value in the range of about 600 nm to about 1000 nm, and wherein the composition exhibits a filtering spectrum having a full width at half maximum of about 58 nm-70 nm.

Claims (34)

1 . A composition for light filtering, the composition comprising:

a base material;

a plurality of gold nanoparticles dispersed in the base material;

a stabilizing mechanism disposed to selectively couple with at least a portion of the plurality of gold nanoparticles to enhance stability of at least the portion of the plurality of gold nanoparticles in the base material; and

an anchoring mechanism disposed to promote chemical conjugation of at least a portion of the plurality of gold nanoparticles to the base material,

wherein the composition exhibits a peak light filtering value in the range of about 600 nm to about 1000 nm, and

wherein the composition exhibits a filtering spectrum having a full width at half maximum of about 58 nm-70 nm.

2 . The composition of claim 1 , wherein the base material comprises a biomaterial.

3 . The composition of claim 1 , wherein the base material comprises a biomaterial matrix.

4 . The composition of claim 1 , wherein the base material comprises hydrogel.

5 . The composition of claim 1 , wherein the base material comprises silicone-based hydrogel.

6 . The composition of claim 1 , wherein at least a portion of the plurality of gold nanoparticles are grown from a pentatwinned gold seed.

7 . The composition of claim 1 , wherein at least a portion of the plurality of gold nanoparticles have an anisotropic shape.

8 . The composition of claim 1 , wherein at least a portion of the plurality of gold nanoparticles have a bipyramid shape.

9 . The composition of claim 8 , wherein a sharpness of the bipyramid shape is tuned such that the composition exhibits a peak light filtering in the range of about 600 nm to about 1000 nm.

10 . The composition of claim 1 , wherein at least a portion of the plurality of gold nanoparticles have with each a pair of opposing truncated peaks disposed on opposing ends.

11 . The composition of claim 10 , wherein a sharpness of the bipyramid shape is tuned such that the composition a peak light filtering in the range of about 600 nm to about 1000 nm.

12 . The composition of claim 1 , wherein the stabilizing mechanism enhances colloidal stability, thermal stability, or both of at least the portion of the plurality of gold nanoparticles in the base material.

13 . The composition of claim 1 , wherein the stabilizing mechanism enhances biocompatibility of at least the portion of the plurality of gold nanoparticles in the base material.

14 . The composition of claim 1 , wherein the stabilizing mechanism comprises poly(vinyl pyrrolidone).

15 . The composition of claim 1 , wherein the stabilizing mechanism comprises 10 kDa poly(vinyl pyrrolidone).

16 . The composition of claim 1 , wherein the stabilizing mechanism comprises 55 kDa poly(vinyl pyrrolidone).

17 . The composition of claim 1 , wherein the stabilizing mechanism comprises 360 kDa poly(vinyl pyrrolidone).

18 . The composition of claim 1 , wherein the stabilizing mechanism comprises 1300 kDa poly(vinyl pyrrolidone).

19 . The composition of claim 1 , wherein the stabilizing mechanism chemically binds with at least a portion of the plurality of gold nanoparticles to enhance colloidal stability of at least the portion of the plurality of gold nanoparticles in the base material.

20 . The composition of claim 1 , wherein the anchoring mechanism comprises a compound including a C═C double bond.

21 . The composition of claim 1 , wherein the anchoring mechanism comprises methacrylate.

22 . The composition of claim 1 , wherein the anchoring mechanism comprises a thiolated compound.

23 . The composition of claim 1 , wherein the anchoring mechanism comprises thiolated methacrylate.

24 . The composition of claim 1 , wherein the anchoring mechanism comprises disulfide-based dimethacrylate.

25 . The composition of claim 1 , wherein the anchoring mechanism comprises dimer (bis(2-methacryloyl)oxyethyl disulfide.

26 . The composition of claim 1 , wherein at least a molar ratio of the stabilizing mechanism and the anchoring mechanism is configured such that the composition exhibits an filtering spectrum having a full width at half maximum of about 58 nm-70 nm.

27 . The composition of claim 1 , wherein an article formed from the composition exhibits stability after autoclaving.

28 . A method of making the composition of claim 1 .

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 16, 2022
From: CLASKY, AARON; GU, FRANK
To: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
Reel/Frame 061116/0451 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 16, 2022
From: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
To: JOHNSON & JOHNSON VISION CARE, INC.
Reel/Frame 061116/0541 →
Continuity (1)
Related Publication 20230348717A1 · Nov 2, 2023
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