Noninvasive optical sensor for analyzing a level of a substance in a subject by illuminating the sclera
A noninvasive optical sensor for analyzing a level of a substance in a subject by illuminating a sclera may include at least one light source, at least one detector, and a processor. The at least one light source may direct incident light to illuminate a region of the sclera of an eye of the subject. The at least one detector may receive light, in response to the incident light, from the sclera or from inside the eye proximal to the illuminated region of the sclera. The processor may be configured to compute a ratio of an intensity of the received light from the at least one detector to a reference value and to estimate a level of a substance in the subject from the computed ratio.
1. An optical sensor device for analyzing a level of a substance of a subject by illuminating a sclera, the optical sensor device comprising:
at least one light source for directing incident light to illuminate a region of a sclera of an eye of a subject;
optics configured to autofocus the incident light onto the region of the sclera;
at least one detector for receiving light, in response to the incident light, from the sclera or from inside the eye proximal to the illuminated region of the sclera; and
a processor configured to compute a ratio of intensity of the received light from the at least one detector to a reference signal and to analyze a level of a substance in the subject from the computed ratio.
2. The optical sensor device according to claim 1 , wherein the received light comprises reflected light from the sclera or from inside the eye proximal to the illuminated region of the sclera.
3. The optical sensor device according to claim 1 , wherein the level of the substance is the level of the substance in the blood of the subject.
4. The optical sensor device according to claim 1 , wherein the received light comprises light emitted by fluorescence from tissue, a substance, or a reagent excited by the incident light from the sclera or from inside the eye proximal to the illuminated region of the sclera.
5. The optical sensor device according to claim 1 , further comprising a communication module for relaying data to a remote mobile device.
6. The optical sensor device according to claim 5 , wherein the communication module comprises a Bluetooth module or a Wireless Fidelity (WiFi) module.
7. The optical sensor device according to claim 5 , wherein the processor is located on the remote mobile device and configured to use the relayed data so as to compute the ratio on the remote mobile device.
8. The optical sensor device according to claim 1 , wherein the at least one light source is selected from the group consisting of a xenon flash lamp, a light emitting diode, a laser diode, and a polychromatic light source with a bandpass filter.
9. The optical sensor device according to claim 1 , wherein the at least one detector is selected from the group consisting of a photodiode, a photomultiplier tube, a photoresistor, a charge coupled device (CCD) sensor, a complementary metal-oxide semiconductor (CMOS) sensor, a fluorescence detector, a filtered photodiode, a spectrometer, and a camera.
10. The optical sensor device according to claim 1 , wherein the at least one light source emits a pulsed light.
11. The optical sensor device according to claim 1 , wherein the level of the substance comprises concentration level of bilirubin in the blood.
12. The optical sensor device according to claim 11 , wherein the incident light directed to the region of the sclera for analyzing the concentration level of bilirubin comprises light from the at least one light source with a wavelength in a range of 400 nm to 500 nm, and wherein the received light in the at least one detector comprises reflected light from the eye in said range.
13. The optical sensor device according to claim 11 , wherein the incident light directed to the region of the sclera for analyzing the concentration level of bilirubin comprises light from the at least one light source with a wavelength in a range of 380 nm to 500 nm, and wherein the received light in the at least one detector comprises light emitted by fluorescence from the eye with a wavelength in a range of 500 nm to 600 nm.
14. The optical sensor device according to claim 11 , wherein the processor is configured to assess that the subject has jaundice when the concentration level of bilirubin in the blood exceeds a predefined threshold.
15. A method for analyzing a level of bilirubin in the blood of a subject by illuminating a sclera using a noninvasive optical sensor device, the method comprising the steps of:
directing incident light having a wavelength in a range from 380 nm to 500 nm from at least one light source to illuminate a region of a sclera of an eye of a subject;
receiving light emitted by fluorescence with a wavelength in a range from 500 nm to 600 nm in at least one detector in response to the incident light, from the sclera or from inside the eye proximal to the illuminated region of the sclera;
computing a ratio of an intensity of the received light from the at least one detector to a reference signal; and
analyzing the level of bilirubin in the blood of the subject from the computed ratio.
16. The method according to claim 15 , wherein directing the incident light to the region of the sclera for analyzing the concentration level of bilirabin comprises directing light from the at least one light source with a wavelength in a range of 400 nm 500 nm.
17. The method according to claim 15 , further comprising assessing that the subject has jaundice when the analyzed concentration level of bilirubin in the blood exceeds a predefined threshold.