Pro-drugs of eliglustat

1. A compound of formula A:

the geometric isomer, enantiomers, diastereomers, racemates, pharmaceutically acceptable salts or solvates thereof,

wherein R is selected from group consisting of:

a)

wherein, R 1 is selected from group consisting of optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, cycloheteroalkyl, amine, alkoxy, carboxylic acid, alkyl substituted with cycloheteroalkyl; alkyl substituted amine, alkyl substituted carboxylic acid, alkene substituted carboxylic acid;

b)

wherein, R 2 is

or

wherein m and p are independently selected from 0 to 3, n is selected from less than 10, about 50, about 100, about 150 or about 200 and Z is alkyl or amine;

c) R 3 wherein, R 3 is selected from group consisting of boron species;

d)

wherein, R 4 is selected from group consisting of alkyl substituted with cycloheteroalkyl, optionally substituted with phosphoryl, alkyl substituted phosphoryl, sulfuryl, sulfonamide; and

e)

wherein, R 5 is selected from group consisting of optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, cycloheteroalkyl, alkyl, amine, alkoxy, carboxylic acid, alkyl substituted with cycloheteroalkyl, alkyl substituted amine.

2. The compound of formula A according to claim 1 , which is represented by the following formula I:

the geometric isomers, enantiomers, diastereomers, racemates, pharmaceutically acceptable salts or solvates thereof;

wherein, R 1 is selected from group consisting of optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, cycloheteroalkyl, amine, alkoxy, carboxylic acid, alkyl substituted with cycloheteroalkyl, alkyl substituted amine, alkyl substituted carboxylic acid, alkene substituted carboxylic acid.

3. The compound of formula A according to claim 1 , which is represented by the following formula II:

the geometric isomers, enantiomers, diastereomers, racemates, pharmaceutically acceptable salts or solvates thereof;

wherein R 2 is

wherein m and p are independently selected from 0 to 3, n is selected from less than 10, about 50, about 100, about 150 or about 200 and Z is alkyl or amine.

4. The compound of formula A according to claim 1 , which is represented by the following formula III:

the geometric isomers, enantiomers, diastereomers, racemates, pharmaceutically acceptable salts or solvates thereof;

wherein R 3 is selected from group consisting of boron species.

5. The compound of formula A according to claim 1 , which is represented by the following formula IV:

the geometric isomers, enantiomers, diastereomers, racemates, pharmaceutically acceptable salts or solvates thereof;

wherein R 4 is selected from group consisting of alkyl substituted with cycloheteroalkyl, optionally substituted phosphoryl, alkyl substituted phosphoryl, sulfuryl, sulfonamide.

6. The compound of formula A according to claim 1 , which is represented by the following formula IX:

the geometric isomers, enantiomers, diastereomers, racemates, pharmaceutically acceptable salts or solvates thereof;

wherein R 5 is selected from group consisting of optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, cycloheteroalkyl, alkyl, amine, alkoxy, carboxylic acid, alkyl substituted with cycloheteroalkyl, alkyl substituted amine.

7. The compound of formula A according to claim 1 , represented by the following formula:

the geometric isomers, enantiomers, diastereomers, racemates, pharmaceutically acceptable salts or solvates thereof;

wherein R 1 is selected from group consisting of:

8. The compound of formula A according to claim 1 , represented by the following formula II:

the geometric isomers, enantiomers, diastereomers, racemates, pharmaceutically acceptable salts or solvates thereof;

wherein R 2 is selected from group consisting of:

9. The compound of formula A according to claim 1 , represented by the following formula III:

the geometric isomers, enantiomers, diastereomers, racemates, pharmaceutically acceptable salts or solvates thereof;

wherein, R 3 is selected from group consisting of:

10. The compound of formula A according to claim 1 , represented by the following formula IV:

the geometric isomers, enantiomers, diastereomers, racemates, pharmaceutically acceptable salts or solvates thereof;

wherein R 4 is selected from group consisting of:

11. The compound of formula A according to claim 1 , represented by the following formula IX:

the geometric isomers, enantiomers, diastereomers, racemates, pharmaceutically acceptable salts or solvates thereof;

wherein R 5 is selected from group consisting of:

12. A compound selected from group consisting of

or pharmaceutically acceptable salt thereof.

13. A pharmaceutical composition comprising compound of formula A represented by following structural formula:

the geometric isomer, enantiomers, diastereomers, racemates, pharmaceutically acceptable salts or solvates thereof; and a pharmaceutically acceptable carrier or an excipient, wherein:

R is selected from group consisting of:

a)

wherein, R 1 is selected from group consisting of optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, cycloheteroalkyl, amine, alkoxy, carboxylic acid, alkyl substituted with cycloheteroalkyl; alkyl substituted amine, alkyl substituted carboxylic acid, alkene substituted carboxylic acid;

b)

wherein, R 2 is

or

wherein m and p are independently selected from 0 to 3, n is selected from less than 10, about 50, about 100, about 150 or about 200 and Z is alkyl or amine;

c) R 3 wherein, R 3 is selected from group consisting of boron species;

d)

wherein, R 4 is selected from group consisting of alkyl substituted with cycloheteroalkyl, optionally substituted phosphoryl, alkyl substituted phosphoryl, sulfuryl, sulfonamide; and

e)

wherein, R 5 is selected from group consisting of optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, cycloheteroalkyl, alkyl, amine, alkoxy, carboxylic acid, alkyl substituted with cycloheteroalkyl; alkyl substituted amine.