Method of treatment with low energy extracorporeal shockwaves

1. A method for preventing an onset of formation of renal fibrosis in a human or animal body for individuals suffering from cancer and as part of a cancer treatment protocol, the method comprising applying a low energy shockwave treatment protocol over a treatment area of at least a kidney of the human or animal body prior to applying a cancer treatment protocol selected from chemotherapy, biological therapy, cell therapy, or stem cell therapy, and wherein said treatment area having or expected to have acute tissue trauma,

a) the low energy shockwave treatment protocol having shockwave parameters including: an energy density from 0.02 and up to 0.2 milliJoules per millimeter squared (mJ/mm2), at a frequency of 2 Hertz (Hz);

b) wherein the low energy shockwave treatment protocol applies a number of low energy shockwaves, wherein the number of applied shockwaves is up to 5000 shockwaves, over at least a portion of the treatment area, and wherein the low energy shockwaves are delivered to the treatment area triggering a cascade of bio-molecular activity involving at least one bio-molecular factor selected from the group consisting of: Transforming Growth Factor beta (TGFbeta); Tissue Inhibitor of MetalloProteinases inhibitor1 (TIMP-1), Focal Adhesion Kinase (FAK), Stem Cell Factor (SCF), Hepatocyte Growth Factor (HGF), the cascade of bio-molecular activity operative to prevent or alleviate fibrosis in and around the treatment area wherein at least one of TGFbeta or TIMP-1 is reduced in expression or wherein of at least one of SCF, HFG or FAK is increased in expression; and

c) wherein said low energy shockwave treatment protocol is initiated within either a 48 hour window or at least one week prior to the cancer treatment protocol.

2. The method of claim 1 wherein said treatment area is divided into a plurality of small treatment zones, wherein each treatment zone is provided with at least 100 shockwaves and up to 500 shockwaves.

3. The method of claim 1 wherein said low energy shockwave treatment protocol is provided in three week treatment phases wherein each week includes up to four treatment sessions.

4. The method of claim 1 wherein said low energy shockwave treatment is provided over a span of up to 9 weeks.

5. The method of claim 4 wherein the low energy shockwave treatment protocol includes up to four active treatment sessions per week.

6. The method of claim 5 wherein the low energy shockwave treatment protocol is configured according the number of active treatment sessions or the number of applied low energy shockwaves so as to cause an increased expression of Focal Adhesion Kinase (FAK) in and around said treatment area; and wherein said increased expression of FAK is proportional to the selected number of the active treatment sessions or the number of applied low energy shockwaves.

7. The method of claim 6 wherein the number of low energy shockwaves delivered in each session is gradually decreasing.