Compositions for the treatment of epithelial lesions
The present invention concerns the field of medications for the treatment of lesions and wounds of the skin and mucosa. The present invention relates to the use of a composition comprising a combination of a mucoadhesive component in the range from 0.05-20% by weight, an emollient component in the range from 0.02-20% by weight, hydrating and mucoprotective component i.e. hyaluronic acid in the range from 0.01-15% by weight and epithelizing component i.e. one or more amino acids in the range from 0.02-5% by weight in the treatment of epithelial lesions. The invention further comprises a composition comprising: —carbomer (poly acrylic acid) in the range from 0.05% to 5%; —sodium hyaluronate in the range from 0.01% to 15%; —poloxamer (copolymers of ethylene oxide and propylene oxide) in the range from 0.1% to 15%; — Oryza sativa extract in the range from 0.2% to 20%; and —one or more amino acids in the range from 0.025% to 5%, wherein said percentages are by weight of the total weight of the product (w/w).
1. A method of treating epithelial lesions in subjects in need thereof, said method comprising
administering to said subjects a composition comprising:
0.5% carbomer (poly acrylic acid);
0.15% sodium hyaluronate;
1% poloxamer (copolymers of ethylene oxide and propylene oxide);
2% Oryza sativa extract;
0.25% proline,
0.25% glutamine and
0.25% hydroxyproline, wherein said percentages are by weight of the total weight (w/w).
2. The method according to claim 1 , wherein said epithelial lesions affect the oral and/or gastrointestinal tract, the rectum, the vagina or the skin.
3. The method according to claim 1 , wherein said epithelial lesions affect the oral and/or gastrointestinal tract and are characterized by impaired tissue following gastro-esophageal reflux or gastric ulcers.
4. The method according to claim 1 , wherein said epithelial lesions are symptoms of in the manifestation of gastro-esophageal reflux disease.
5. The method according to claim 1 , wherein said epithelial lesions are skin lesions selected from the group consisting of skin ulcers, skin injuries including those derived from atopic dermatitis, burns, wounds, acne or insect bites.
6. The method according to claim 1 , for topical application or for oral administration.
7. The method according to claim 6 , wherein when said administration is oral administration, said composition is in the solid form of a tablet, capsule, powder, granules, toothpaste, oral cream or gel, candy, dissolvable pill or strip, chewing gum, lozenge or powder or in liquid form of suspension, emulsion, solution, oral spray or mouth wash.
8. The method according to claim 1 , wherein said composition is in a liquid form for oral use.
9. A composition comprising:
0.5% carbomer (poly acrylic acid);
0.15% sodium hyaluronate;
1% poloxamer (copolymers of ethylene oxide and propylene oxide);
2% Oryza sativa extract;
0.25% proline,
0.25% glutamine and
0.25% hydroxyproline, wherein said percentages are by weight of the total weight (w/w).