Integrated nasal nerve detector ablation-apparatus, nasal nerve locator, and methods of use

1. A system for ablating at least one nasal nerve associated with at least one symptom of rhinitis, the system comprising:

a probe shaft having a proximal end and a distal end;

an expandable ablation member permanently coupled to the distal end of the probe shaft;

at least two electrodes disposed on a distal tip that is releasably coupled to the probe shaft, the at least two electrodes electrically coupled to an electrical source, wherein the at least two electrodes are configured to electrically stimulate at least one nasal nerve underlying a nasal surface in contact with the least two electrodes in response to an electrical current generated by the electrical source, wherein the least two electrodes are configured to detect a parameter indicative of a physiologic response to the electrical current; and

a processor operatively coupled to the electrical source, wherein the processor is configured to:

control the electrical current generated by the electrical source,

receive the parameter indicative of the physiologic response to the electrical current, wherein the physiologic response is at least one physiologic response selected from a group consisting of: a change in nasal secretion and a change in arterial blood flow, and

control, based on the parameter, the electrical current generated by the electrical source to cause the least two electrodes to ablate the at least one nasal nerve underlying the nasal surface to reduce the at least one symptom associated with rhinitis.

2. The system of claim 1 , wherein the at least two electrodes are spaced apart in a range from 1 mm to 10 mm.

3. The system of claim 1 , wherein the at least two electrodes are configured to stimulate 1 mm to 3 mm under the nasal surface in contact with the at least two electrodes.

4. The system of claim 1 , wherein the probe shaft is sized so that the distal end of the probe shaft can reach a nasal mucosa covering a medial pterygoid plate of sphenoid bone through a passage of a middle nasal meatus from outside a nasal cavity.

5. The system of claim 1 , wherein the processor is configured to control at least one feature selected from a group consisting of: a voltage, a frequency, and a pulse rate of the electrical current.

6. The system of claim 1 , wherein the parameter is at least one parameter selected from a group consisting of: an electrical resistance, a temperature, and a degree of tumescence of the at least one nasal nerve underlying the nasal surface.

7. The system of claim 6 , wherein the at least two electrodes are configured to detect a change in electrical resistance in an electrical signal passing through the at least two electrodes after stimulation of the at least one nasal nerve underlying the nasal surface, the change in resistance being indicative of a change in nasal secretion after stimulation of the at least one nasal nerve underlying the nasal surface.

8. The system of claim 1 , wherein the expandable ablation member comprises an electrically non-conductive surface, and wherein the at least two electrodes are disposed on the electrically non-conductive surface of the expandable ablation member.

9. The system of claim 1 , wherein a first electrode of the at least two electrodes is disposed at a central location of the expandable ablation member, and a second electrode of the at least two electrodes is disposed along a perimeter of the expandable ablation member.

10. The system of claim 1 , wherein the at least two electrodes comprises four electrodes arranged rectangularly on the expandable ablation member such that the four electrodes are configured to stimulate four quadrants of the expandable ablation member.

11. The system of claim 1 , wherein the expandable ablation member is configured to inflate so as to position the at least two electrodes adjacent to the nasal surface.

12. The system of claim 1 , wherein the expandable ablation member comprises an expandable cryoablation member configured to cryogenically ablate the at least one nasal nerve to reduce at least one symptom associated with rhinitis.

13. The system of claim 1 , wherein the distal tip includes a connector that is coupled to a connection portion of the probe shaft that is proximal to the expandable ablation member.

14. The system of claim 13 , wherein the distal tip extends from the connection portion to a distal end disposed distally of the expandable ablation member, and wherein the at least two electrodes are disposed at the distal end of the distal tip such that the at least two electrodes are distal to the expandable ablation member.

15. The system of claim 1 , wherein the processor is further configured to:

control the electrical current generated by the electrical source through the at least two electrodes after ablating the at least one nasal nerve to confirm that the at least one nasal nerve has been ablated.

16. The system of claim 1 , further comprising:

at least one sensor, wherein the sensor is configured to detect the parameter indicative of a physiologic response to the electrical current, and wherein the at least one sensor is disposed on the probe shaft.

17. The system of claim 1 , wherein controlling the electrical current generated by the electrical source comprises delivering electric pulses through the at least two electrodes at a frequency between 0.5 impulses per second to 12 impulses per second.

18. The system of claim 1 , wherein the processor is further configured to:

measure a response to the electrical current using the at least two electrodes; and

provide an indication to reposition the probe and stimulating the at least two electrodes until a desired response is measured using the at least two electrodes.