Skin care composition
Methods and compositions for improving the appearance of skin are provided. The methods and compositions are especially suited for inhibiting activation of PAR2 in skin by utilizing a synergistic combination of a water lily extract and vitamin B 3 compound. The method involves treating hyperpigmented skin by applying a skin care composition containing an effective amount of a combination of water lily extract and vitamin B 3 compound to a target portion of skin over the course of a treatment period.
1. A method of synergistically inhibiting PAR2 activation, comprising:
a) identifying a target portion of skin on a person where treatment is desired; and
b) applying a composition comprising:
i) a hydrolysate comprising an aqueous extract of Nymphaea alba flowers and thermally inactivated enzymes; wherein the hydrolysate comprises from about 20% to about 70% carbohydrate, by weight of the dry matter of the hydrolysate; and
ii) a vitamin B 3 compound;
wherein the composition targets a portion of skin during a treatment period,
wherein the hydrolysate and vitamin B 3 compound are present at a volume/weight ratio of hydrolysate to niacinamide of 1:4 to 5:1.
2. The method of claim 1 , wherein the hydrolysate and vitamin B 3 compound are present at a volume/weight ratio of hydrolysate to vitamin B 3 of 1:2 to 2.5:1.
3. The method of claim 1 , wherein the vitamin B 3 compound is niacinamide.
4. The method of claim 2 , wherein the niacinamide is present at about 0.0001% to about 10% by weight of the composition.
5. The method of claim 1 , wherein the composition comprises about 0.00001% to about 10% hydrolysate, by weight, based on the weight of the composition.
6. The method of claim 5 , wherein the synergistic inhibition of PAR2 activation is at least 10% more than a calculated additive effective according to the PAR2 Inhibition Assay.
7. A topical skin care composition, comprising:
a) about 0.4%, by weight of the skin care composition, of a hydrolysate comprising an aqueous extract of Nymphaea alba flowers and thermally inactivated enzymes; wherein the hydrolysate comprises from about 20% to about 70% carbohydrate, by weight of the dry matter of the hydrolysate; and
b) about 5%, by weight of the skin care composition, of a vitamin B 3 compound;
c) a dermatologically acceptable carrier.
8. The skin care composition of claim 7 , wherein the vitamin B 3 compound is niacinamide and is present at about 0.001% to about 10% by weight of the composition.
9. The skin care composition of claim 7 , wherein the composition comprises about 0.0001% to about 10% hydrolysate, by weight, based on the weight of the composition.
10. The skin care composition of claim 7 , wherein the hydrolysate comprises about 20% to about 60% mineral based on the weight of the dry matter.
11. The skin care composition of claim 7 , wherein the hydrolysate comprises less than about 3% polyphenol based on the weight of the dry matter of the hydrolysate.
12. The skin care composition of claim 7 , wherein the composition further comprises at least one additional ingredient chosen from vitamins, minerals, sugar amines, sunscreen agents, oil control agents, flavonoid compounds, anti-oxidants, preservatives, protease inhibitors, tyrosinase inhibitors, anti-inflammatory agents, moisturizing agents, exfoliating agents, skin lightening agents, lubricants, anti-acne actives, chelating agents, anti-wrinkle actives, anti-atrophy actives, phytosterols, N-acyl amino acid compounds, antimicrobials, and antifungals, conditioning agents, emulsifiers, rheology modifiers, or mixtures thereof.
13. The skin care composition of claim 12 , wherein the additional ingredient includes a superabsorbent polymer thickening agent chosen from sodium polyacrylate, starch grafted sodium polyacrylate, or mixtures thereof.
14. The method of claim 1 , wherein the hydrolysate comprises less than 15% peptide, based on the weight of dry matter of the hydrolysate.
15. The method of claim 1 , wherein the hydrolysate comprises less than 10% peptide, based on the weight of dry matter of the hydrolysate.
16. The skin care composition of claim 7 , wherein the hydrolysate comprises less than 15% peptide, based on the weight of dry matter of the hydrolysate.
17. A topical skin care composition, comprising:
a) about 0.4%, by weight of the skin care composition, of a hydrolysate comprising an aqueous extract of Nymphaea alba flowers and thermally inactivated enzymes; wherein the hydrolysate comprises from about 20% to about 70% carbohydrate, by weight of the dry matter of the hydrolysate; and
b) about 5%, by weight of the skin care composition, of a niacinamide;
c) about 5%, by weight of the skin care composition, glycerin; and
d) water.
18. The topical skin care composition of claim 17 , wherein the composition further comprises:
a) about 2%, by weight of the composition, dimethicone/ dimethiconol
b) about 0.5%, by weight of the composition, dexpanthenol; and
c) tocopherol acetate.
19. The topical skin care composition of claim 18 , wherein the composition further comprises:
about 0.05%, by weight of the composition, disodium EDTA; and
about 0.1%, by weight of the composition, PEG-100 Stearate.