Aryl piperidines as monoacylglycerol lipase modulators

1. A compound of Formula (I):

wherein

X is CH 2 or O;

R 2a and R 2b are each independently selected from H and C 1-4 alkyl;

R 3 is selected from:

(a) phenyl; phenyl substituted with one, two or three members each independently selected from: halo, C 1-6 alkyl, C 1-6 haloalkyl, C(CH 3 ) 2 OH, OC 1-6 alkyl, OC 1-6 haloalkyl, SCH 3 , SF 5 , Si(CH 3 ) 3 , N(CH 3 ) 2 , C 3-6 cycloalkyl, OC 3-6 cycloalkyl, phenyl, O-phenyl, O-pyridyl and C 3-6 cycloalkyl substituted with CH 3 ; and

(b) pyridyl substituted with C 1-6 alkyl; naphthyl;

R 4 is selected from: H, F, and C 1-3 alkyl; and

R 5a and R 5b are each independently selected from H and CH 3 ;

or a pharmaceutically acceptable salt, isotope, N-oxide, solvate, or stereoisomer thereof.

2. The compound of claim 1 , wherein X is CH 2 .

3. The compound of claim 1 , wherein X is O.

4. The compound of claim 1 , wherein R 2a and R 2b are each H.

5. The compound of claim 1 , wherein R 2a and R 2b are each CH 3 .

6. The compound of claim 1 , wherein R 2a is H and R 2b is CH 3 .

7. The compound of claim 1 , wherein R 3 is phenyl; or phenyl substituted with one, two or three members each independently selected from: Cl, F, C 1-6 alkyl, C 1-6 haloalkyl, C(CH 3 ) 2 OH, OC 1-6 alkyl, OC 1-6 haloalkyl, SCH 3 , Si(CH 3 ) 3 , SF 5 , N(CH 3 ) 2 , C 3-6 cycloalkyl, C 3-6 cycloalkyl substituted with CH 3 , OC 3-6 cycloalkyl, phenyl, O-phenyl, and O-pyridyl.

8. The compound of claim 7 , wherein R 3 is phenyl substituted with one, two or three members each independently selected from: Cl, F, C 1-6 alkyl, C 1-6 haloalkyl, OC 1-6 alkyl, OC 1-6 haloalkyl, SCH 3 , SF 5 , and Si(CH 3 ) 3 .

9. The compound of claim 7 , wherein R 3 is 4-trifluoromethylphenyl, 3-trifluoromethoxyphenyl, 3-tert-butylphenyl, 4-tert-butylphenyl, or 3-(1-methylcyclopropyl)phenyl.

10. The compound of claim 1 , wherein R 4 is H, F, CH 3 or CH 2 CH 3 .

11. The compound of claim 1 , wherein R 5a and R 5b are each H.

12. The compound of claim 1 , wherein R 5a is CH 3 and R 5b is H or R 5a is H and R 5b is CH 3 .

13. The compound of claim 1 , wherein

14. A compound selected from:

(2s,4s)-2-(4-(3-(2,2,2-Trifluoroethyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3-Fluoro-5-(trifluoromethoxy)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(2-Fluoro-5-(trifluoromethoxy)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(2-Methyl-4-(trifluoromethyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-(Difluoromethyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3-(Trifluoromethoxy)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(2-Methyl-4-(trifluoromethoxy)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3-Methyl-4-(trifluoromethoxy)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-Cyclopropylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-Isopropylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-(Difluoromethoxy)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-Methyl-3-(trifluoromethyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3-(tert-Butyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3-Isopropylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2r,4s)-2-(4-(4-Methyl-3-(trifluoromethyl)phenyl)piperidine-1-carbonyl)-5-azaspiro[3.4]octan-6-one;

(2r,4s)-2-(4-(4-Cyclopropylphenyl)piperidine-1-carbonyl)-5-azaspiro[3.4]octan-6-one;

(2r,4s)-2-(4-(3-Methyl-4-(trifluoromethyl)phenyl)piperidine-1-carbonyl)-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(2-Fluoro-4-methylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-(2,2,2-Trifluoroethyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3-Fluoro-4-methylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2r,4s)-2-(4-(3-(tert-Butyl)phenyl)piperidine-1-carbonyl)-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3-Cyclopropylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(2,2-Difluorobenzo[d][1,3]dioxol-5-yl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-Cyclobutylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3-(1,1-Difluoroethyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-(1-Methylcyclopropyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-(1,1-Difluoroethyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3-Fluoro-5-methylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(2,3-Difluoro-4-methylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(2,5-Difluoro-4-methylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2r,4s)-2-(4-(4-Isopropylphenyl)piperidine-1-carbonyl)-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(2-Fluoro-5-methylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3,4-Dimethylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(2,3-Dihydro-1H-inden-5-yl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3-Chloro-4-methylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(2-Fluoro-3-methylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3-Isopropoxyphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2r,4s)-2-(4-(4-(1-Methylcyclopropyl)phenyl)piperidine-1-carbonyl)-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3-(1-Methylcyclopropyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2r,4s)-2-(4-(3-(1-Methylcyclopropyl)phenyl)piperidine-1-carbonyl)-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(1H-Inden-5-yl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(2,3-Dimethylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-Fluoro-3-methylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(6-(tert-Butyl)pyridin-3-yl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(2-Chlorophenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(2,4-Dimethylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-Phenoxyphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3-Methoxy-4-(trifluoromethyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(2-Cyclopropylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2r,4s)-2-(4-(4-Phenoxyphenyl)piperidine-1-carbonyl)-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(2-Methyl-3-(trifluoromethyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3-Phenoxyphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-Chloro-3-methylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(2-Methoxy-4-(trifluoromethyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(2-(Trifluoromethoxy)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-([1,1′-Biphenyl]-3-yl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-Methoxy-3-(trifluoromethoxy)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-(Pyridin-2-yloxy)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-Chloro-3-(trifluoromethoxy)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-Fluoro-3-(trifluoromethoxy)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(2-Chloro-3-(trifluoromethoxy)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(2-Methyl-3-(trifluoromethoxy)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2r,4s)-2-(4-(3-Methyl-4-(trifluoromethoxy)phenyl)piperidine-1-carbonyl)-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-Cyclopropyl-2-methylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3-(tert-Butyl)-4-chlorophenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3-(Difluoromethoxy)-4-methylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3-(tert-Butyl)-4-fluorophenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2r,4s)-2-(4-(2-Methyl-3-(trifluoromethoxy)phenyl)piperidine-1-carbonyl)-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3-Methyl-5-(trifluoromethoxy)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-(Difluoromethoxy)-3-methylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(2-Methyl-5-(trifluoromethyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2r,4s)-2-(4-(3-(tert-Butyl)-4-chlorophenyl)piperidine-1-carbonyl)-5-azaspiro[3.4]octan-6-one;

(2r,4s)-2-(4-(2-Chloro-3-(trifluoromethoxy)phenyl)piperidine-1-carbonyl)-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-Cyclopropoxyphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(2-Fluoro-3-(trifluoromethoxy)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3-(Pentafluoro-λ6-sulfaneyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-(Pentafluoro-λ6-sulfaneyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2r,4s)-2-(4-(3-(tert-Butyl)-4-fluorophenyl)piperidine-1-carbonyl)-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-Isobutylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(racemic)-(2s,4s)-8-Methyl-2-(4-(4-(1-methylcyclopropyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3-(2-Hydroxypropan-2-yl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3-Isobutylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-(2-Hydroxypropan-2-yl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3,5-Dimethylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(2,4-Difluoro-3-methylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-(Trimethylsilyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-Fluoro-2,3-dimethylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(2,5-Dimethylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3-Ethyl-4-fluorophenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3, 5-Difluoro-4-methylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2S*,4s,8R*)-8-Methyl-2-(4-(4-(1-methylcyclopropyl)phenyl)piperidine--carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2R*,4s,8S*)-8-Methyl-2-(4-(4-(1-methylcyclopropyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3-(Trimethylsilyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2r,4s)-2-(4-(4-(Trimethylsilyl)phenyl)piperidine-1-carbonyl)-5-azaspiro[3.4]octan-6-one;

(2r,4s)-2-(4-(3-Isobutylphenyl)piperidine-1-carbonyl)-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-(tert-Butyl)-3-methoxyphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-Methoxy-3-(trifluoromethyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(racemic)-(2s,4s)-2-(4-(4-(sec-Butyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(racemic)-(2r,4s)-2-(4-(4-(sec-Butyl)phenyl)piperidine-1-carbonyl)-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(1H-Pyrrolo[2,3-b]pyridin-2-yl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-[4-(6-Fluorobenzofuran-3-yl)piperidine-1-carbonyl]-6-oxa-8-azaspiro[3.4]octan-7-one;

(2s,4s)-2-(4-(4-(Trifluoromethyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(Benzofuran-2-yl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(Naphthalen-2-yl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(1H-Indol-2-yl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-(Trifluoromethoxy)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-(Methylthio)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-(Dimethylamino)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(5-Chlorobenzofuran-2-yl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-Phenylpiperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(p-Tolyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(Naphthalen-1-yl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-Fluorophenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3-Chlorophenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(o-Tolyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-Ethylphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3-(Trifluoromethyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(2-Fluorophenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3-Fluorophenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-Chlorophenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(m-Tolyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-Methoxyphenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-(tert-Butyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2r,4s)-2-(4-(4-(Trifluoromethyl)phenyl)piperidine-1-carbonyl)-5-azaspiro[3.4]octan-6-one;

(2r,4s)-2-(4-(5-Chlorobenzofuran-2-yl)piperidine-1-carbonyl)-5-azaspiro[3.4]octan-6-one;

(2r,4s)-2-(4-(4-(tert-Butyl)phenyl)piperidine-1-carbonyl)-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-Methyl-4-phenylpiperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(6-Chlorobenzo[d]isoxazol-3-yl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(racemic)-(2s,4s)-2-(4-(4-(tert-Butyl)phenyl)piperidine-1-carbonyl)-8-methyl-7-oxa-5-azaspiro[3.4]octan-6-one;

(2S*,4s,18R*)-2-(4-(4-(tert-Butyl)phenyl)piperidine--carbonyl)-8-methyl-7-oxa-5-azaspiro[3.4]octan-6-one;

(2R*,4s,8S*)-2-(4-(4-(tert-Butyl)phenyl)piperidine-1-carbonyl)-8-methyl-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-(tert-Butyl)phenyl)piperidine-1-carbonyl)-8,8-dimethyl-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-Chlorophenyl)-4-methylpiperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(Benzo[d]thiazol-2-yl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-Methyl-4-(p-tolyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-Fluoro-4-phenylpiperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-Methyl-3-(trifluoromethoxy)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4s)-2-(4-(4-Chlorophenyl)-4-ethylpiperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(racemic)-(2s,4S)-2-((3R,4R)-4-(4-(tert-Butyl)phenyl)-3-methylpiperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4S*)-2-((3R*,4R*)-4-(4-(tert-Butyl)phenyl)-3-methylpiperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4R*)-2-((3S*,4S*)-4-(4-(tert-Butyl)phenyl)-3-methylpiperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(racemic)-(2r,4S)-2-((3R,4R)-4-(4-(tert-Butyl)phenyl)-3-methylpiperidine-1-carbonyl)-5-azaspiro[3.4]octan-6-one;

(racemic)-(2s,4s)-2-(4-(4-(tert-Butyl)phenyl)-2-methylpiperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(racemic)-(2s,4S)-2-((3R,4R)-3-Methyl-4-(3-(trifluoromethoxy)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(racemic)-(2s,4S)-2-((3R,4R)-3-Methyl-4-(3-methyl-4-(trifluoromethoxy)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(racemic)-(2s,4S)-2-((3R,4R)-3-Methyl-4-(3-(trifluoromethyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(racemic)-(2s,4S)-2-((3R,4R)-3-Methyl-4-(4-(trifluoromethoxy)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(racemic)-(2s,4S)-2-((3R,4R)-3-Methyl-4-(3-fluoro-4-(trifluoromethoxy)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(racemic)-(2s,4S)-2-((3R,4R)-3-Methyl-4-(4-(trifluoromethyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(racemic)-(2s,4S)-2-((3R,4R)-3-Methyl-4-(4-methyl-3-(trifluoromethyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(racemic)-(2s,4S)-2-((3R,4R)-3-Methyl-4-(3-methyl-4-(trifluoromethyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(racemic)-(2s,4S)-2-((3R,4R)-4-([1,1′-Biphenyl]-3-yl)-3-methylpiperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(racemic)-(2r,4S)-2-((3R,4R)-4-([1,1′-Biphenyl]-3-yl)-3-methylpiperidine-1-carbonyl)-5-azaspiro[3.4]octan-6-one;

(2s,4R*)-2-((2S*,4R*)-2-Methyl-4-(4-(trifluoromethyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4S*)-2-((2R*,4S*)-2-Methyl-4-(4-(trifluoromethyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4S*)-2-((2R*,4R*)-2-Methyl-4-(4-(trifluoromethyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4R*)-2-((2S*,4S*)-2-Methyl-4-(4-(trifluoromethyl)phenyl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4S*)-2-((3R*,4R*)-4-([1,1′-Biphenyl]-3-yl)-3-methylpiperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4R*)-2-((3S*,4S*)-4-([1,1′-Biphenyl]-3-yl)-3-methylpiperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(racemic)-(2s,4R)-2-((2S,4S)-4-(3-(tert-Butyl)phenyl)-2-methylpiperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4R*)-2-((2S*,4R*)-4-(4-(tert-Butyl)phenyl)-2-methylpiperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4S*)-2-((2R*,4R*)-4-(4-(tert-Butyl)phenyl)-2-methylpiperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4S*)-2-((2R*,4S*)-4-(4-(tert-Butyl)phenyl)-2-methylpiperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4R*)-2-((2S*,4S*)-4-(4-(tert-Butyl)phenyl)-2-methylpiperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4R*)-2-((2S*,4R*)-4-(3-(tert-Butyl)phenyl)-2-methylpiperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

(2s,4S*)-2-((2R*,4S*)-4-(3-(tert-Butyl)phenyl)-2-methylpiperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one; and

(2s,4s)-2-(4-(6-(tert-Butyl)pyridin-2-yl)piperidine-1-carbonyl)-7-oxa-5-azaspiro[3.4]octan-6-one;

or a pharmaceutically acceptable salt, isotope, N-oxide, solvate, or stereoisomer thereof.

15. The compound of claim 1 , having the structure of Formula (IA):

wherein

R 3 is selected from:

(a) phenyl substituted with one or two members each independently selected from: halo, C 1-6 alkyl, C 1-6 haloalkyl, OC 1-6 haloalkyl, Si(CH 3 ) 3 , C 3-6 cycloalkyl, phenyl, O-phenyl, and C 3-6 cycloalkyl substituted with CH 3 ; and

(b)

and

R 5b is H or CH 3 ;

or a pharmaceutically acceptable salt, isotope, N-oxide, solvate, or stereoisomer thereof.

16. A compound of Formula (IB):

wherein

R 2a and R 2b are each independently selected from H and CH 3 ;

R 3 is selected from:

(a) phenyl; phenyl substituted with one, two or three members each independently selected from: Cl, F, C 1-6 alkyl, C 1-6 haloalkyl, C(CH 3 ) 2 OH, OC 1-6 alkyl, OC 1-6 haloalkyl, SCH 3 , SF 5 , Si(CH 3 ) 3 , N(CH 3 ) 2 , cyclopropyl, cyclobutyl, O-cyclopropyl, phenyl, O-phenyl, O-pyridyl and

 and

(b)

R 4 is selected from: H, F, CH 3 and CH 2 CH 3 ;

R 5a is H or CH 3 ; and

R 5b is H or CH 3 ;

or a pharmaceutically acceptable salt, isotope, N-oxide, solvate, or stereoisomer thereof.

17. A pharmaceutical composition comprising:

(A) a therapeutically effective amount of at least one compound of claim 1 , or a pharmaceutically acceptable salt, isotope, N-oxide, solvate, or stereoisomer thereof; and

(B) at least one pharmaceutically acceptable excipient.

18. A method of inhibiting the progress of or lessening the severity of a disease, disorder, or condition mediated by MGL receptor activity in a subject suffering from or diagnosed therewith, comprising administering to a subject in need of such treatment a therapeutically effective amount of at least one compound of claim 1 , or a pharmaceutically acceptable salt, isotope, N-oxide, solvate, or stereoisomer thereof, wherein the MGL receptor mediated disease, disorder or condition is selected from: (a) pain, psychiatric conditions, neurological conditions, cancers, and eye conditions; (b) major depressive disorder, treatment-resistant depression, anxious depression, autism spectrum disorders, Asperger syndrome, and bipolar disorder; and (c) inflammatory pain.