Intravascular measurement and data collection systems, apparatus and methods
A method and apparatus for determining properties of a tissue or tissues imaged by optical coherence tomography (OCT). In one embodiment the backscatter and attenuation of the OCT optical beam is measured and based on these measurements and indicium such as color is assigned for each portion of the image corresponding to the specific value of the backscatter and attenuation for that portion. The image is then displayed with the indicia and a user can then determine the tissue characteristics. In an alternative embodiment the tissue characteristics is classified automatically by a program given the combination of backscatter and attenuation values.
1. A method of analyzing and imaging a blood vessel, the method comprising:
storing image data of the blood vessel, in an electronic memory device, wherein the image data is generated using an imaging probe;
generating one or more images of the blood vessel, using a computing device, from the image data, wherein the one or more images comprises one or more portions of a wall of the blood vessel;
detecting a lumen boundary, using the computing device, with regard to the one or more images;
detecting a tissue boundary, using the computing device, with regard to the one or more images, wherein the tissue boundary defines a region of tissue having a single tissue type, and wherein detecting the tissue boundary comprises identification of a profile of intensity versus corresponding depth in the blood vessel from the image data, and identification of one or more discontinuities in a linearization of the profile of the intensity versus corresponding depth;
determining the tissue type, using the computing device; and
displaying, using a display in electrical communication with the computing device, a first image from the one or more images, wherein the display of the first image includes adding a first visual representation of the tissue boundary shown in the first image and a second visual representation of the single tissue type relative to the first image.
2. The method of claim 1 , wherein the tissue type is a tissue comprising calcium.
3. The method of claim 1 , wherein the second visual representation are selected from a group consisting of an overlay, a colormap, a color, a texture map, and text.
4. The method of claim 1 , wherein determining the tissue type comprises performing a statistical discriminant analysis of region of the one or more images within the tissue boundary.
5. The method of claim 1 , wherein the tissue type is selected from the group consisting of cholesterol, fiber, lipid, fibrofatty, red thrombus, white thrombus, foam cells, and proteoglycan.
6. The method of claim 1 , further comprising populating a database with histology data collected in parallel with collection of image data; and determining the tissue type using the populated database.
7. The method of claim 1 , wherein the first visual representation of the tissue boundary is based on the one or more discontinuities.
8. The method of claim 1 , wherein the imaging probe is a rotatable optical coherence tomography probe that is disposed in and pulled back through a lumen of the blood vessel.
9. The method of claim 8 further comprising correcting a focusing effect of imaging probe to improve tissue type determination, wherein the rotatable optical coherence tomography probe comprises a lens to send and receive light.
10. The method of claim 8 further comprising rotating the imaging probe and applying an angular intensity correction to account for an attenuation effect.
11. The method of claim 8 , wherein the image data comprises backscattering data.
12. The method of claim 11 further comprising comparing the backscattering data to a first threshold, the backscattering data mapping to a first location in the one or more images; and if the backscattering data exceeds the first threshold, characterize the first location in the one or more images as having a first tissue characteristic.
13. The method of claim 8 , wherein the image data comprises backscattering data and attenuation data.
14. The method of claim 13 further comprising determining the tissue type at a location in the blood vessel corresponding to an image location in one of the one or more images in response to the attenuation value and backscattering value at the image location.
15. The method of claim 13 further comprising measuring an attenuation value and a backscattering value at a point in the blood vessel, wherein the point is within the tissue boundary.
16. The method of claim 15 further comprising determining the tissue type at the point in response to the measured attenuation value and backscattering value.
17. The method of claim 13 , wherein determining the tissue type further comprises generating a backscatter-attenuation space.
18. The method of claim 17 , wherein determining the tissue type further comprises mapping a pair of coordinates in the backscatter-attenuation space to the second visual representation of a value of the pair of coordinates in the backscatter-attenuation space.
19. The method of claim 13 further comprising determining backscattering coefficients and attenuation coefficients from the backscattering data and attenuation data.
20. The method of claim 19 , further comprising plotting pairs of backscattering coefficients and attenuation coefficients; and determining different tissue types based on clusters formed in the plot of such pairs.