Anti-pain compound and preparation method thereof
Disclosed are a compound represented by the general Formula (I), or a stereisomer, tautomer, derivative, prodrug or pharmaceutically acceptable salt thereof, and a method for preparing the compound and use of the compound in manufacture of a medicament for treating a neuropathic pain and/or neuropathic pain syndrome or a medicament for combating an inflammation: wherein R 1 is selected from hydrogen, halogen, alkyl, cyano and haloalkyl, R 2 and R 3 are independently selected from hydrogen, halogen, alkyl, haloalkyl and nitro, and R 1 , R 2 and R 3 are not hydrogen at the same time; furthermore, when either R 2 or R 3 is nitro or halogen, the other two of R 1 , R 2 and R 3 are not hydrogen at the same time. The compound has good effects in treating a neuropathic pain and/or neuropathic pain syndrome and good effects in combating an inflammation, and has not side effects such as addiction.
1. A compound represented by the Formula (II), or a stereoisomer, tautomer, prodrug, or pharmaceutically acceptable salt thereof:
wherein R 1 is selected from the group consisting of hydrogen, fluorine, bromine, cyano and haloalkyl,
R 2 is selected from the group consisting of hydrogen, halogen, alkyl and nitro, and R 1 and R 2 are not hydrogen at the same time;
and when R 2 is nitro or halogen, R 1 is not hydrogen.
2. The compound according to claim 1 , or a stereoisomer, tautomer, prodrug, or pharmaceutically acceptable salt thereof, wherein the compound is represented by Formula (II):
wherein R 1 is fluorine, bromine or haloalkyl; R 2 is hydrogen or nitro.
3. The compound according to claim 1 , or a stereoisomer, tautomer, prodrug or pharmaceutically acceptable salt thereof, wherein R 1 is cyano, fluorine, bromine or haloalkyl, and R 2 is hydrogen.
4. The compound according to claim 1 , or a stereoisomer, tautomer, prodrug, or pharmaceutically acceptable salt thereof, wherein R 1 is fluorine, bromine or haloalkyl, and R 2 is hydrogen.
5. The compound, or a stereoisomer, tautomer, prodrug, or pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of:
6. A pharmaceutical composition, the pharmaceutical composition comprising the compound according to claim 1 , or a stereoisomer, tautomer, prodrug, or pharmaceutically acceptable salt thereof, and optionally a pharmaceutically acceptable carrier.
7. A pharmaceutical composition, the pharmaceutical composition comprising the compound according to claim 5 , or a stereoisomer, tautomer, prodrug, or pharmaceutically acceptable salt thereof, and optionally a pharmaceutically acceptable carrier.
8. A method for relieving a pain or combating an inflammation, the method comprising administrating the compound according to claim 1 , or a stereoisomer, tautomer, prodrug, or pharmaceutically acceptable salt thereof to a subject in need thereof.
9. A method for relieving a pain or combating an inflammation, the method comprising administering the compound according to claim 5 , or a stereoisomer, tautomer, prodrug, or pharmaceutically acceptable salt thereof to a subject in need thereof.
10. The compound according to claim 1 , or a stereoisomer, tautomer, prodrug, or pharmaceutically acceptable salt thereof, wherein R 2 is alkyl, and R 1 is hydrogen.
11. The compound according to claim 1 , or a stereoisomer, tautomer, prodrug, or pharmaceutically acceptable salt thereof, wherein R 2 is methyl or ethyl, and R 1 is hydrogen.
12. The compound according to claim 1 , or a stereoisomer, tautomer, prodrug, or pharmaceutically acceptable salt thereof, wherein R 1 is selected from the group consisting of fluorine, bromine, cyano and haloalkyl, and R 2 is selected from the group consisting of halogen, alkyl, and nitro.
13. The compound according to claim 1 , or a stereoisomer, tautomer, prodrug, or pharmaceutically acceptable salt thereof, wherein R 1 is selected from the group consisting of fluorine, bromine, cyano and trifluoromethyl, and R 2 is selected from the group consisting of fluorine, chlorine, bromine, methyl, ethyl, and nitro.
14. The compound according to claim 1 , or a stereoisomer, tautomer, prodrug, or pharmaceutically acceptable salt thereof, wherein R 1 is fluorine or bromine, and R 2 is halogen.
15. The compound according to claim 1 , or a stereoisomer, tautomer, prodrug, or pharmaceutically acceptable salt thereof, wherein the alkyl is methyl, ethyl or propyl.