IP Library › Granted Patent US 11,801,310
Granted Patent B2
US 11,801,310 · App. 16/232,601 · Granted Oct 31, 2023

Composition for improving the solubility of poorly soluble substances, use thereof and complex formulation containing thereof

Inventors: Wen-Chia Huang (Taichung, TW); Yen-Jen Wang (Taichung, TW); Felice Cheng (Zhubei, TW); Chia-Ching Chen (Taichung, TW); Shao-Chan Yin (Tainan, TW); Chien-Lin Pan (Hsinchu, TW); Tsan-Lin Hu (Jhubei, TW); Meng-Nan Lin (Zhubei, TW); Kuo-Kuei Huang (Zhubei, TW); Maggie Lu (Zhudong Township, TW); Chih-Peng Liu (Hsinchu, TW)
Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
A61K47/6951A61K9/0019A61K9/0048A61K9/0053A61K9/08A61K31/4439A61K31/569A61K47/38A61K47/40A61K47/65
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Quick Facts
Patent No.
US 11,801,310
App. No.
16/232,601
Granted
Oct 31, 2023
Kind
B2
Abstract

A composition for improving the solubility of poorly soluble substances is provided. The composition includes about 40-99.5% by weight of cyclodextrin and/or derivatives thereof; about 0.05-10% by weight of at least one water-soluble polymer; and about 0.05-60% by weight of at least one water-soluble stabilizer.

Claims (8)

1. A composition for improving the solubility of poorly soluble substances, comprising:

40-99.5% by weight of cyclodextrin and/or a derivative thereof;

0.05-10% by weight of at least one water-soluble polymer; and

0.05-20% by weight of at least one water-soluble stabilizer, wherein the at least one water-soluble stabilizer comprises adenine or guanine.

2. The composition for improving the solubility of poorly soluble substances as claimed in claim 1 , wherein the cyclodextrin comprises α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin, δ-cyclodextrin or a combination thereof.

3. The composition for improving the solubility of poorly soluble substances as claimed in claim 1 , wherein the derivative of cyclodextrin comprises hydroxypropyl modified cyclodextrin, succinyl modified cyclodextrin, methyl modified cyclodextrin or a combination thereof.

4. The composition for improving the solubility of poorly soluble substances as claimed in claim 3 , wherein the hydroxypropyl modified cyclodextrin comprises hydroxypropyl-γ-cyclodextrin (hydroxypropyl-γ-CD).

5. The composition for improving the solubility of poorly soluble substances as claimed in claim 1 , wherein the at least one water-soluble polymer comprises hydroxypropyl methyl cellulose (HPMC), hydroxypropyl cellulose, carboxymethyl cellulose (CMC), polyvinylpyrrolidone, (PVP), polyvinyl alcohol, poly(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol) (PEG-PPG-PEG (ABA)) triblock copolymer or a combination thereof.

Assignments (3)
LICENSE Recorded May 6, 2025
From: METAGONE BIOTECH INC.
To: BRIM BIOTECHNOLOGY INC.
Reel/Frame 071189/0957 →
LICENSE Recorded Aug 11, 2023
From: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
To: METAGONE BIOTECH INC.
Reel/Frame 064561/0399 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 6, 2019
From: HUANG, WEN-CHIA; WANG, YEN-JEN; CHENG, FELICE; CHEN, CHIA-CHING; YIN, SHAO-CHAN; PAN, CHIEN-LIN; HU, TSAN-LIN; LIN, MENG-NAN; HUANG, KUO-KUEI; LU, MAGGIE; LIU, CHIH-PENG
To: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
Reel/Frame 049089/0726 →
Priority Claims (1)
EP 18215590 · Dec 21, 2018 · regional
Continuity (2)
Provisional Application 62610509 · Dec 26, 2017
Related Publication 20190209706A1 · Jul 11, 2019