NK-1 antagonist compositions and methods for use in treating depression

1. A pharmaceutical combination comprising, as Component (a) a NK1-antagonist, in a pharmaceutical composition in dosage unit form comprising, as an active ingredient, said NK1-antagonist, in an amount per unit form of from 1 mg to 600 mg, in admixture with a pharmaceutical carrier or vehicle, and (b) pramipexole or a pharmaceutically acceptable salt or solvate thereof, in an amount per unit form equivalent to from 0.125 mg to 21 mg of pramipexole dihydrochloride monohydrate, in admixture with a pharmaceutical carrier.

2. The combination of claim 1 , wherein said pramipexole or pharmaceutically acceptable salt or solvate thereof is in an amount per unit form equivalent to from more than 4.5 mg to 21 mg or from more than 6 mg to 21 mg of pramipexole dihydrochloride monohydrate.

3. The combination of claim 1 , which is a fixed-dose combination consisting of a pharmaceutical composition comprising

(a) said NK1-antagonist, in an amount per unit form of from 1 mg to 600 mg; and

(b) pramipexole or a pharmaceutically acceptable salt or solvate thereof, in an amount per unit form equivalent to from 0.125 mg to 21 mg of pramipexole dihydrochloride monohydrate,

in admixture with a pharmaceutical carrier or vehicle.

4. The combination of claim 3 , wherein, in said pharmaceutical composition, said pramipexole or pharmaceutically acceptable salt or solvate thereof is in an amount per unit form equivalent to from more than 4.5 mg to 21 mg or from more than 6 mg to 21 mg of pramipexole dihydrochloride monohydrate.

5. The combination of claim 1 , wherein said NK1-antagonist is aprepitant, in an amount per unit form in a range of from 10 mg to 250 mg.

6. The combination of claim 3 , wherein said NK1-antagonist is aprepitant, in an amount per unit form in a range of from 10 mg to 250 mg.