Dilutable formulations of cannabinoids and processes for their preparation

1. A formulation in the form of a microemulsion, said formulation comprising:

at least one oil mixture that comprises a mixture of oleic acid and linoleic acid, said oil mixture being present in the formulation in an amount of between about 0.5 wt % and about 20 wt %,

at least one hydrophilic surfactant in an amount of between about 30 and about 85 wt %, said at least one hydrophilic surfactant is selected from the group consisting of polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monooleate, polyoxyethylene esters of saturated and unsaturated castor oil, ethoxylated monoglycerol esters, ethoxylated fatty acids, and combinations thereof,

at least one co-surfactant in an amount of between about 1 wt % and about 50 wt %, the ratio between the at least one hydrophilic surfactant and the at least one co-surfactant is between about 1:1 and 6:1 (wt/wt), said at least one co-surfactant is selected from the group consisting of polyols, diglycerides, polyglyceryl-3 dioleate, polyoxyethylenes, and combinations thereof, and

at least one cannabinoid in an amount of between about 0.1 wt % and about 12 wt %, the at least one cannabinoid is selected from the group consisting of cannabigerolic acid (CBGA), cannabigerolic acid monomethylether (CBGAM), cannabigerol (CBG), cannabigerol monomethylether (CBGM), cannabigerovarinic acid (CBGVA), cannabigerovarin (CBGV), cannabichromenic acid (CBCA), cannabichromene (CBC), cannabichromevarinic acid (CBCVA), cannabichromevarin (CBCV), cannabidiolic acid (CBDA), cannabidiol (CBD), cannabidiol monomethylether (CBDM), cannabidiol-C 4 (CBD-C 4 ), cannabidivarinic acid (CBDVA), cannabidiorcol (CBD-C 1 ), delta-9-tetrahydrocannabinolic acid A (THCA-A), delta-9-tetrahydrocannabinolic acid B (THCA-B), delta-9-tetrahydrocannabinol (THC), delta-9-tetrahydrocannabinolic acid-C 4 (THCA-C 4 ), delta-9-tetrahydrocannabivarinic acid (THCVA), delta-9-tetrahydrocannabivarin (THCV), delta-9-tetrahydrocannabiorcolic acid (THCA-C 1 ), delta-9-tetrahydrocannabiorcol (THC-C 1 ), delta-7-cis-iso-tetrahydrocannabivarin, delta-8-trtrahydrocannabinolic acid A (Δ 8 -THCA), delta-8-tetrahydrocannabinol (Δ 8 -THC), cannabicyclolic acid (CBLA), cannabicyclol (CBL), cannabicyclovarin (CBLV), cannabielsoic acid A (CBEA-A), cannabielsoic acid B (CBEA-B), cannabielsoin (CBE), cannabinolic acid (CBNA), cannabinol (CBN), cannabinol methylether (CBNM), cannabinol-C 4 (CBN-C 4 ), cannabivarin (CBV), cannabinol-C 2 (CBN-C 2 ), cannabiorcol (CBN-C 1 ), cannabinodiol (CBND), cannabinodivarin (CBVD), cannabitriol (CBT), 10-ethoxy-9-hydroxy-delta-6a-tetrahydrocannabinol, 8,9-dihydroxy-delta-6a-tetrahydrocannabinol, cannabitriolvarin (CBTV), ethoxy-cannabitriolvarin (CBTVE), dehydrocannabifuran (DCBF), cannabifuran (CBF), cannabichromanon (CBCN), cannabicitran (CBT), 10-oxo-delta-6a-tetrahydrocannabinol (OTHC), delta-9-cis-tetrahydrocannabinol (cis-THC), 3,4,5,6-tetrahydro-7-hydroxy-α-α-2-trimethyl-9-n-propyl-2,6-methano-2H-1-benzoxocin-5-methanol (OH-iso-HHCV), cannabiripsol (CBR), trihydroxy-delta-9-tetrahydroxycannabinol (triOH-THC), and mixtures thereof;

the formulation being in form of a water-free microemulsion having a droplet size of between about 5 nm and about 100 nm, being fully dilutable by an aqueous diluent and maintaining a microemulsion structure when diluted.

2. The formulation of claim 1 , wherein the at least one cannabinoid is selected from the group consisting of cannabidiol (CBD), cannabidiolic acid (CBDA), tetrahydrocannabinol (THC), or a combination thereof.

3. The formulation of claim 2 , wherein the at least one cannabinoid is cannabidiol (CBD).

4. The formulation of claim 1 , wherein the formulation comprises at least one additional oil, different from said oil mixture, wherein said at least one additional oil is selected from the group consisting of mineral oil, paraffinic oils, vegetable oils, glycerides, esters of fatty acids, liquid hydrocarbons and mixtures thereof.

5. The formulation of claim 4 , wherein the at least one additional oil is selected from the group consisting of medium-chain triglycerides (MCT), olive oil, soybean oil, canola oil, cotton oil, palmolein, sunflower oil, corn oil, rapeseed oil, grape seeds oil, hemp oil, pomegranate oil, avocado oil, peppermint oil, tomato oil, isopropyl myristate, oleyl lactate, coco caprylocaprate, hexyl laurate, oleyl amine, oleyl alcohol, linoleyl alcohol, ethyl oleate, hexane, heptanes, nonane, decane, dodecane, D-limonene, neem oil, lavender oil, anise oil, rosemary oil, sage oil, hibiscus oil, berries oil, menthol, capsaicin, grape seed oil, pumpkin oil, and similar essential oils of triglycerides and esters of fatty acids and mixtures thereof.

6. The formulation of claim 1 , having a droplet size of between about 5 and about 30 nanometers.

7. A pharmaceutical composition comprising the formulation of claim 1 .

8. The pharmaceutical composition of claim 7 , being in a form selected from a gel, a lotion, oil, soap, a spray, an emulsion, a cream, an ointment, capsules, soft-gel capsules, a patch, or a solution.

9. The pharmaceutical composition of claim 7 , adapted for delivery of said cannabinoid topically, orally, by inhalation, nasally, transdermally, ocularly or parenterally into the circulatory system of a subject.

10. The pharmaceutical composition of claim 7 , further comprising a pharmaceutically acceptable carrier.

11. The pharmaceutical composition of claim 7 , further comprising a diluent.

12. A formulation in the form of a microemulsion, said formulation comprising:

at least one oil mixture comprising a mixture of oleic acid and linoleic acid, said oil mixture being present in the formulation in an amount of between about 0.5 wt % and about 20 wt %,

polyglycerol ester,

at least one hydrophilic surfactant in an amount of between about 30 and about 85 wt %, said at least one hydrophilic surfactant is selected from the group consisting of polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monooleate, polyoxyethylene esters of saturated and unsaturated castor oil, ethoxylated monoglycerol esters, ethoxylated fatty acids, and combinations thereof,

at least one cosurfactant in an amount of between about 1 wt % and about 50 wt %, said at least one co-surfactant is selected from the group consisting of polyols, diglycerides, polyoxyethylenes, and combinations thereof, and

at least one cannabinoid in an amount of between about 0.1 wt % and about 12 wt %, the at least one cannabinoid is selected from the group consisting of cannabigerolic acid (CBGA), cannabigerolic acid monomethylether (CBGAM), cannabigerol (CBG), cannabigerol monomethylether (CBGM), cannabigerovarinic acid (CBGVA), cannabigerovarin (CBGV), cannabichromenic acid (CBCA), cannabichromene (CBC), cannabichromevarinic acid (CBCVA), cannabichromevarin (CBCV), cannabidiolic acid (CBDA), cannabidiol (CBD), cannabidiol monomethylether (CBDM), cannabidiol-C 4 (CBD-C 4 ), cannabidivarinic acid (CBDVA), cannabidiorcol (CBD-C 1 ), delta-9-tetrahydrocannabinolic acid A (THCA-A), delta-9-tetrahydrocannabinolic acid B (THCA-B), delta-9-tetrahydrocannabinol (THC), delta-9-tetrahydrocannabinolic acid-C 4 (THCA-C 4 ), delta-9-tetrahydrocannabivarinic acid (THCVA), delta-9-tetrahydrocannabivarin (THCV), delta-9-tetrahydrocannabiorcolic acid (THCA-C 1 ), delta-9-tetrahydrocannabiorcol (THC-C 1 ), delta-7-cis-iso-tetrahydrocannabivarin, delta-8-tetrahydrocannabinolic acid A (Δ 8 -THCA), delta-8-tetrahydrocannabinol (Δ 8 -THC), cannabicyclolic acid (CBLA), cannabicyclol (CBL), cannabicyclovarin (CBLV), cannabielsoic acid A (CBEA-A), cannabielsoic acid B (CBEA-B) cannabielsoin (CBE), cannabinolic acid (CBNA), cannabinol (CBN), cannabinol methylether (CBNM), cannabinol-C 4 (CBN-C 4 ), cannabivarin (CBV), cannabinol-C 2 (CBN-C 2 ), cannabiorcol (CBN-C 1 ), cannabinodiol (CBND), cannabinodivarin (CBVD), cannabitriol (CBT), 10-ethoxy-9-hydroxy-delta-6a-tetrahydrocannabinol, 8,9-dihydroxy-delta-6a-tetrahydrocannabinol, cannabitriolvarin (CBTV), ethoxy-cannabitriolvarin (CBTVE), dehydrocannabifuran (DCBF), cannabifuran (CBF), cannabichromanon (CBCN), cannabicitran (CBT), 10-oxo-delta-6a-tetrahydrocannabinol (OTHC), delta-9-cis-tetrahydrocannabinol (cis-THC) 3,4,5,6-tetrahydro-7-hydroxy-α-α-2-trimethyl-9-n-propyl-2,6-methano-2H-1-benzoxocin-5-methanol (OH-iso-HHCV), cannabiripsol (CBR), trihydroxy-delta-9-tetrahydroxycannabinol (triOH-THC), and mixtures thereof;

the formulation being in form of a water-free microemulsion having a droplet size of between about 5 nm and about 100 nm, being fully dilutable by an aqueous diluent and maintaining the microemulsion structure when diluted.