Adjusting phases of multiphase ablation generator to detect contact
A radio frequency ablation system, includes a single frequency RF signal generator, control circuitry configured to set phases and amplitudes of a plurality of replicas of the RF signal, a plurality of non-linear amplifiers, configured to amplify the plurality of replicas of the RF signal, and to drive a respective plurality of ablation electrodes in a patient body with the amplified replicas. A processor is configured to receive a superposition of the plurality of replicas as a return signal from a body surface patch electrode, and to adaptively adjust phases and amplitudes of the amplified replicas in response to the return signal with the control circuitry to zero crosstalk currents. In a tissue contact check mode of operation the phases of the amplified replicas are identical, and in an ablation mode of operation the phases of the amplified replicas differ from one another.
1. A radio frequency (RF) ablation system, comprising:
a signal generator configured to generate an RF signal having a given frequency;
control circuitry, configured to set phases and amplitudes of a plurality of replicas of the RF signal generated by the signal generator;
a plurality of non-linear amplifiers, configured to amplify the plurality of replicas of the RF signal, and to drive a respective plurality of ablation electrodes in a patient body with the amplified replicas; and
a processor configured to:
analyze a return signal from a patch electrode attached to the patient body, the return signal comprising a superposition of the plurality of replicas sensed by the patch electrode,
ablate the target tissue with the plurality of ablation electrodes in an ablation mode, and
adaptively adjust phases and amplitudes of the amplified replicas, based at least in part on the return current, by controlling the control circuitry such that in the ablation mode of operation the amplified replicas are adjusted such that the phases of the amplified replicas differ from one another and cross-talk between the electrodes of the plurality of electrodes is reduced.
2. The system according to claim 1 , wherein in the ablation mode of operation the phases of the amplified replicas differ from one another by at least 3.6 degrees.
3. The system according to claim 1 , further comprising a measurement circuit, configured to measure the replicas that are amplified respectively by the amplifiers, wherein the processor is configured to adjust the phases and the amplitudes of the replicas based on the measured replicas in the ablation mode of operation.
4. The system according to claim 1 , and comprising a catheter, configured to be inserted into the patient body, to which the plurality of electrodes are attached.
5. The system according to claim 4 , wherein the catheter comprises one of an inflatable balloon and an expandable basket assembly.
6. The system of claim 1 , wherein the processor is further configured to:
determine, based at least in part on the return signal while the plurality of replicas are in phase with each other, that a state of contact exists between the ablation electrodes and target tissue in a tissue contact mode.
7. The system according to claim 1 , wherein in the ablation mode of operation a voltage of the RF signal is between 27V RMS and 47VRMS.
8. The system according to claim 6 , wherein a tissue contacted in the tissue contact mode comprises a pulmonary vein.
9. The system of claim 1 ,
wherein the return signal comprises a return current, and
wherein the processor is configured to adaptively adjust phases and amplitudes of the amplified replicas based at least in part on the return current.
10. A method of ablation, comprising the steps of:
generating a plurality of replicas of an RF signal having a given frequency;
setting phases and amplitudes of the plurality of replicas;
amplifying the plurality of replicas of the RF signal, and driving a respective plurality of ablation electrodes in a patient body with the amplified replicas;
analyzing a return signal comprising a superposition of the plurality of replicas sensed by a patch electrode;
determining, based at least in part on the return signal while the plurality of replicas are in phase with each other, that a state of contact exists between the ablation electrodes and target tissue in the patient in a tissue contact mode;
ablating the target tissue with the ablation electrodes in an ablation mode of operation; and
adjusting, during the ablation mode, phases of the plurality of replicas to be out of phase with each other and reduce cross talk between electrodes of the respective plurality of ablation electrodes.
11. The method according to claim 10 , wherein in the ablation mode of operation the phases of the amplified replicas differ from one another by at least 3.6 degrees.
12. The method according to claim 10 , further comprising:
making measurements of the replicas; and
responsively to the measurements zeroing crosstalk currents between the ablation electrodes by adjusting the phases and the amplitudes of the replicas in the ablation mode of operation.
13. The method of claim 10 , wherein the determining step comprises:
switching the replicas of current injected to the plurality of ablation electrodes to be in-phase while applying a voltage at increasing level and measuring the replicas of current with an analyzer; and
checking whether tissue is in contact when the in-phase replicas of current injected into each electrode requires a voltage increase greater than a zero base value.
14. The method according to claim 10 , and comprising attaching the plurality of electrodes to a catheter configured to be inserted into the patient body.
15. The method according to claim 10 , wherein a tissue contacted in the tissue contact mode comprises a pulmonary vein.
16. The method according to claim 10 , wherein in the ablation mode of operation a voltage of the RF signal is between 27V RMS and 47VRMS.
17. A method to ablate tissue in a system having a signal generator configured to generate an RF signal coupled to a control circuitry, the control circuitry configured to set phases and amplitudes of a plurality of replicas of the RF signal generated by the signal generator with a plurality of non-linear amplifiers to amplify the plurality of replicas of the RF signal and drive a respective plurality of n ablation electrodes in a patient body with the amplified replicas; and a processor, configured to analyze a return signal comprising a superposition of the plurality of replicas sensed by a patch electrode attached to the patient body, the method comprising the steps of: switching the replicas of current injected to the n ablation electrodes to be in-phase while applying a voltage at increasing level and measuring the replicas of current with an analyzer, checking whether tissue is in contact when the in-phase replicas of current injected into each electrode requires a change in voltage greater than a zero base value, and changing the n ablation electrodes to be out of-phase to continue ablation of the tissue such that phases of the plurality of replicas are adjusted to be out of phase with each other and cross-talk between electrodes of the n ablation electrodes is reduced.
18. The method of claim 17 , wherein the steps of switching the n ablation electrodes to be in-phase and changing the n ablation electrodes to be out-of-phase are conducted at a rate many times per second.
19. The method of claim 18 , wherein the rate comprises a rate of 50 Hz.
20. The method of claim 17 , wherein the n ablation electrodes comprise any number of electrodes from 2 to 192.