Altering temperature in a mammalian body
The present application relates to systems and methods for altering temperature in a mammalian body. Optionally, the systems and methods can be used to lower or raise core body temperature of a mammalian subject. Optionally, the systems and methods can be used to lower or raise the temperature of glabrous skin of a mammalian subject.
1. A method of cooling or maintaining a cooled core body temperature of a mammal subject, comprising:
inducing and maintaining a condition of vasodilation in glabrous tissue of the subject, wherein the inducing and maintaining of vasodilation in the glabrous tissue does not include applying a mechanical force caused by application of pressure to the glabrous tissue of the subject sufficient to induce or maintain increased blood flow in the glabrous tissue; and
applying a cooling stimulus using a cooling device localized to the glabrous tissue, to skin overlying the glabrous tissue, or both, during the maintenance of the vasodilation condition therein the glabrous tissue, wherein the localized cooling application cools blood in the vasodilated vasculature of the glabrous tissue, said cooled blood circulating to the subject's body core to cause cooling or maintenance of the subject's cooled core body temperature.
2. The method of claim 1 , wherein the induction and maintenance of vasodilation is activated by localized heating of the subject's peripheral thermoregulatory control tissue located in the cervical or lumbar spine region of the subject.
3. The method of claim 1 , wherein the induction and maintenance of vasodilation is a result of anesthesia.