Systems and methods for reduction of oxygen tension in electrochemical biosensors
In one embodiment, a system for detecting an analyte in a bodily fluid sample includes an electrochemical biosensor, the electrochemical biosensor configured to receive the bodily fluid sample, test for the analyte, and produce an analyte level for the analyte. The system further includes a mediator, the mediator configured to provide for the testing of the analyte by facilitating electron exchange between the analyte and the biosensor. The system further includes an oxygen tension reducing agent, the oxygen tension reducing agent reducing interference of oxygen with the operation of the mediator.
1. A method of testing for an analyte, with reduced interference of oxygen, the method comprising:
providing a system including:
an electrochemical biosensor, the electrochemical biosensor configured to receive a bodily fluid sample, test for the analyte, and produce an analyte level for the analyte;
a mediator, the mediator configured to provide for the testing of the analyte by facilitating electron exchange between the analyte and the biosensor, wherein the mediator is ferrocyanide and the analyte is hemoglobin;
an oxygen tension reducing agent;
a meter for receiving the electrochemical biosensor;
dosing the electrochemical biosensor with a sample containing the analyte;
reducing the interference of oxygen with the operation of the mediator with the oxygen tension reducing agent;
detecting an electrical property of the sample with the meter and electrochemical biosensor; and,
calculating an analyte level of the analyte with the meter,
wherein the oxygen tension reducing agent is laccase.
2. The method of claim 1 , further comprising reducing the interference of oxygen with the oxygen tension reducing agent, wherein the oxygen reducing reagent is laccase.
3. A method of testing for an analyte, with reduced interference of oxygen, the method comprising:
providing a system including:
an electrochemical biosensor, the electrochemical biosensor configured to receive a bodily fluid sample, test for the analyte, and produce an analyte level for the analyte;
a mediator, the mediator configured to provide for the testing of the analyte by facilitating electron exchange between the analyte and the biosensor, wherein the mediator is ferrocyanide and the analyte is hemoglobin;
an oxygen tension reducing agent;
a meter for receiving the electrochemical biosensor;
dosing the electrochemical biosensor with a sample containing the analyte;
reducing the interference of oxygen with the operation of the mediator with the oxygen tension reducing agent;
detecting an electrical property of the sample with the meter and electrochemical biosensor; and,
calculating an analyte level of the analyte with the meter,
wherein the oxygen tension reducing agent is a platinum electrode.
4. The method of claim 3 , wherein the reducing includes activating the platinum electrode at oxygen reducing voltage, which causes the platinum electrode to reduce oxygen interference, and then activating the platinum electrode at a detection voltage.