IP Library › Granted Patent US 11,857,981
Granted Patent B2
US 11,857,981 · App. 16/835,090 · Granted Jan 2, 2024

Magnetic separator for an automated single cell sequencing system

Inventors: Pratomo Alimsijah (Pleasanton, CA); John Richard Chevillet (Pleasanton, CA)
Assignee: 10x Genomics, Inc.
B03C1/288B01L3/5085B01L3/50855B01L9/523B03C1/01B03C1/0332B01L2400/043B03C2201/18B03C2201/26
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Quick Facts
Patent No.
US 11,857,981
App. No.
16/835,090
Granted
Jan 2, 2024
Kind
B2
Abstract

A magnetic separator is disclosed. The magnetic separator comprises an array of magnets configured to interact with a tube holder plate, wherein the tube holder plate comprises an array of tubes. The magnetic separator comprises a raised frame extending around a periphery of the array of magnets such that the raised frame is configured to support the tube holder plate such that the array of tubes is suspended above the array of magnets.

Claims (20)

1. A magnetic separator, comprising:

an array of magnets configured to interact with a tube holder plate, wherein the tube holder plate comprises an array of tubes, wherein the array of magnets and the array of tubes are two-dimensional and each tube of the array of tubes has a different corresponding magnet of the array of magnets; and

a raised frame extending around a periphery of the array of magnets such that the raised frame is configured to support the tube holder plate such that the array of tubes is suspended above the array of magnets.

2. The magnetic separator of claim 1 , wherein the array of tubes is suspended above the array of magnets at a height such that each tube of the array of tubes does not come in contact with the corresponding magnet of the array of magnets.

3. The magnetic separator of claim 1 , wherein the array of magnets comprises an array of ring magnets, and wherein the array of tubes is suspended above the array of ring magnets such that the bottom ends of the tubes are not resting within the hollow spaces of the ring magnets at different depths.

4. The magnetic separator of claim 3 , wherein the array of tubes is suspended above the array of ring magnets such that the tube holder plate is leveled with respect to the array of ring magnets.

5. The magnetic separator of claim 1 , wherein the array of magnets is held by a magnet holder plate, and wherein the raised frame comprises a plurality of feet, wherein each foot of the plurality of feet fits into a corresponding hole on the magnet holder plate such that the raised frame is mounted on the magnet holder plate.

6. The magnetic separator of claim 5 , wherein the raised frame is mounted on the magnet holder plate such that the raised frame is raised above the magnet holder plate.

7. The magnetic separator of claim 1 , wherein the raised frame comprises a plurality of collars, wherein each of the collars constrains a x location and a y location of the tube holder plate.

8. The magnetic separator of claim 7 , wherein each of the collars constrains the x location and the y location of the tube holder plate by having a tube of the array of tubes inserted into the collar.

9. A method, comprising:

providing an array of magnets configured to interact with a tube holder plate, wherein the tube holder plate comprises an array of tubes, wherein the array of magnets and the array of tubes are two-dimensional and each tube of the array of tubes has a different corresponding magnet of the array of magnets; and

providing a raised frame extending around a periphery of the array of magnets such that the raised frame is configured to support the tube holder plate such that the array of tubes is suspended above the array of magnets.

10. The method of claim 9 , wherein the array of tubes is suspended above the array of magnets at a height such that each tube of the array of tubes does not come in contact with the corresponding magnet of the array of magnets.

11. The method of claim 9 , wherein the array of magnets comprises an array of ring magnets, and wherein the array of tubes is suspended above the array of ring magnets such that the bottom ends of the tubes are not resting within the hollow spaces of the ring magnets at different depths.

12. The method of claim 11 , wherein the array of tubes is suspended above the array of ring magnets such that the tube holder plate is leveled with respect to the array of ring magnets.

13. The method of claim 9 , wherein the array of magnets is held by a magnet holder plate, and wherein the raised frame comprises a plurality of feet, wherein each foot of the plurality of feet fits into a corresponding hole on the magnet holder plate such that the raised frame is mounted on the magnet holder plate.

14. The method of claim 13 , wherein the raised frame is mounted on the magnet holder plate such that the raised frame is raised above the magnet holder plate.

15. The method of claim 9 , wherein the raised frame comprises a plurality of collars, wherein each of the collars constrains a x location and a y location of the tube holder plate.

16. The method of claim 15 , wherein each of the collars constrains the x location and the y location of the tube holder plate by having a tube of the array of tubes inserted into the collar.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 13, 2020
From: ALIMSIJAH, PRATOMO; CHEVILLET, JOHN RICHARD
To: 10X GENOMICS, INC.
Reel/Frame 054359/0648 →
Continuity (3)
Provisional Application 62980768 · Feb 24, 2020
Provisional Application 62953050 · Dec 23, 2019
Related Publication 20210187515A1 · Jun 24, 2021