Composition for improving, preventing or treating skin disease comprising induced pluripotency stem cell-derived mesenchymal stem cells pretreated with interferon gamma and exosomes derived therefrom
View Patent ↗The present invention may provide a method for producing induced pluripotency stem cell-derived mesenchymal stem cells (IFNγ-iMSC) pretreated with interferon-gamma; induced pluripotency stem cell-derived mesenchymal stem cells pretreated with interferon-gamma prepared by the method; a pharmaceutical composition for preventing or treating skin diseases, and a cosmetic composition for preventing or improving skin diseases, comprising culture thereof or exosome (IFNγ-iMSC-exo) isolated therefrom as an active ingredient. When the composition of the present invention is used, it is possible to provide a composition for skin diseases and a stem cell therapeutic agent, which have an improved immunomodulating function over conventional mesenchymal stem cells.
1. A method for treating or alleviating a skin disease selected from the group consisting of atopic dermatitis, contact dermatitis, and psoriasis, in a subject in need thereof, comprising:
administering to the subject a composition comprising (i) interferon-gamma-pretreated mesenchymal stem cells or a culture thereof, or (ii) exosomes isolated from interferon-gamma-pretreated mesenchymal stem cells or a culture thereof,
wherein the mesenchymal stem cells are induced pluripotent stem cell-derived mesenchymal stem cells (iMSC).
2. The method of claim 1 , wherein the subject is a mammal or a human.