Compression exertion device
Embodiments of the present invention are directed to devices, systems and methods adapted for implementing intermittent displacement of blood to mitigate peripheral nerve neuropathy such as that induced by chemotherapeutic agents (i.e., chemotherapy-induced neuropathy (CIN)) that are administered to a patient. Such devices, systems and methods advantageously provide for precise, uniform and controlled blood flow occluding (and optionally blood displacing) compression along irregular surfaces of an appendage of a patient. Such precise, uniform and controlled blood occluding compression is imparted upon the epidermal and dermis skin layers within the aforementioned areas of a patient's extremities to decrease the time that free nerve endings located in the epidermal and encapsulated nerve endings located in the dermis skin layers are exposed to nerve damaging chemotherapy chemicals, thereby substantially decreasing CIN caused by prolonged exposure to such chemicals.
1. A compression exertion device of a peripheral nerve neuropathy mitigation system used during chemotherapy treatment for limiting exposure of nerve endings within a body part of a patient to chemotherapy chemicals within blood to which the nerve endings are exposed, wherein the peripheral nerve neuropathy system is operable to enable pressurization of the compression exertion device for causing compressive pressure to be exerted by the compression exertion device on the body part, the compression exertion device comprising:
an outer enclosure having a body part receiving space adapted for having a body part of a patient engaged therein, wherein the body part receiving space encompasses at least a portion of an exterior surface of the body part;
a cavity partition attached to a perimeter edge portion of the outer enclosure, wherein at least the outer enclosure and the cavity partition jointly define an expansion cavity at least partially encompassing the body part receiving space and wherein the expansion cavity is at a first side of the cavity partition;
a body part engaging seal component at the perimeter edge portion of the outer enclosure, wherein the cavity partition and the body part engaging seal component at least partially define a flowable medium receiving space and wherein the flowable medium receiving space is at a second side of the cavity partition; and
a volume of tissue-treating medium within the flowable medium receiving space, wherein the tissue-treating medium comprises a perfluorocarbon oxygen-carrying compression inducing medium.
2. A compression exertion device of a peripheral nerve neuropathy mitigation system used during chemotherapy treatment for limiting exposure of nerve endings within a body part of a patient to chemotherapy chemicals within blood to which the nerve endings are exposed, wherein the peripheral nerve neuropathy system is operable to enable pressurization of the compression exertion device for causing compressive pressure to be exerted by the compression exertion device on the body part, the compression exertion device comprising:
an outer enclosure having a body part receiving space adapted for having a body part of a patient engaged therein, wherein the body part receiving space encompasses at least a portion of an exterior surface of the body part;
a cavity partition attached to a perimeter edge portion of the outer enclosure, wherein at least the outer enclosure and the cavity partition jointly define an expansion cavity at least partially encompassing the body part receiving space and wherein the expansion cavity is at a first side of the cavity partition;
a body part engaging seal component at the perimeter edge portion of the outer enclosure, wherein the cavity partition and the body part engaging seal component at least partially define a flowable medium receiving space and wherein the flowable medium receiving space is at a second side of the cavity partition; and
a volume of tissue-treating medium within the flowable medium receiving space, wherein the tissue-treating medium comprises an aqueous oxygen carrying compression inducing medium that comprises negatively charged nano sized oxygen bubbles.
3. A compression exertion device of a peripheral nerve neuropathy mitigation system used during chemotherapy treatment for limiting exposure of nerve endings within a body part of a patient to chemotherapy chemicals within blood to which the nerve endings are exposed, wherein the peripheral nerve neuropathy system is operable to enable pressurization of the compression exertion device for causing compressive pressure to be exerted by the compression exertion device on the body part, the compression exertion device comprising:
an outer enclosure having a body part receiving space adapted for having a body part of a patient engaged therein, wherein the body part receiving space encompasses at least a portion of an exterior surface of the body part;
a cavity partition attached to a perimeter edge portion of the outer enclosure, wherein at least the outer enclosure and the cavity partition jointly define an expansion cavity at least partially encompassing the body part receiving space and wherein the expansion cavity is at a first side of the cavity partition;
a body part engaging seal component at the perimeter edge portion of the outer enclosure, wherein the cavity partition and the body part engaging seal component at least partially define a flowable medium receiving space and wherein the flowable medium receiving space is at a second side of the cavity partition; and
a volume of tissue-treating medium within the flowable medium receiving space, wherein the tissue-treating medium is oxygen enriched.
4. A compression exertion device of a peripheral nerve neuropathy mitigation system used during chemotherapy treatment for limiting exposure of nerve endings within a body part of a patient to chemotherapy chemicals within blood to which the nerve endings are exposed, wherein the peripheral nerve neuropathy system is operable to enable pressurization of the compression exertion device for causing compressive pressure to be exerted by the compression exertion device on the body part, the compression exertion device comprising:
an outer enclosure having a body part receiving space adapted for having a body part of a patient engaged therein, wherein the body part receiving space encompasses at least a portion of an exterior surface of the body part;
a cavity partition attached to a perimeter edge portion of the outer enclosure, wherein at least the outer enclosure and the cavity partition jointly define an expansion cavity at least partially encompassing the body part receiving space and wherein the expansion cavity is at a first side of the cavity partition;
a body part engaging seal component at the perimeter edge portion of the outer enclosure; and
a pressure distribution article at least one of adjacent to and attached to at least one of the cavity partition, the outer enclosure, and the body part engaging seal component, wherein the cavity partition and the pressure distribution article at least partially define a flowable medium receiving space, wherein the flowable medium receiving space is at a second side of the cavity partition, and wherein at least a portion of the pressure distribution article is made from a material having an open pore structure extending through a thickness thereof; and
a volume of tissue-treating medium within the flowable medium receiving space, wherein pores of the open pore structure have an oxygen carrying medium therein.
5. The compression exertion device of claim 1 wherein the body part engaging seal component, the outer enclosure and the cavity partition jointly define the flowable medium receiving space.
6. The compression exertion device of claim 2 wherein the body part engaging seal component, the outer enclosure and the cavity partition jointly define the flowable medium receiving space.
7. The compression exertion device of claim 3 wherein the tissue-treating medium comprises at least one of dissolved oxygen, oxygen bubbles, and oxygen-enriched air.
8. The compression exertion device of claim 3 further comprising:
at least one sensor at least one of attached to and in functional contact with at least one of the outer enclosure, the cavity partition, and the body part engaging seal component, wherein the at least one sensor is operable to enable monitoring of at least one of compressive pressure, blood oxygen, and blood flow and adjusting the compressive pressure to mitigate peripheral nerve neuropathy resulting from reduced blood flow within at least a portion of the body part.
9. The compression exertion device of claim 3 , further comprising:
a pressure distribution article at least one of adjacent to and attached to at least one of the cavity partition, the outer enclosure, and the body part engaging seal component, wherein the pressure distribution article and at least one of the cavity partition, the outer enclosure, and the body part engaging seal component jointly form the flowable medium receiving space.
10. The compression exertion device of claim 3 further comprising:
at least one sensor at least one of attached to and in functional contact with at least one of the outer enclosure, the cavity partition, and the body part engaging seal component, wherein the at least one sensor is operable to enable monitoring at least one of compressive pressure, blood oxygen, and blood flow and adjusting the compressive pressure to mitigate peripheral nerve neuropathy resulting from reduced blood flow within at least a portion of the body part.
11. The compression exertion device of claim 4 wherein the pressure distribution article is a self-contouring pressure distribution article that uniformly applies compressive pressure onto irregular surfaces of the body part.
12. The compression exertion device of claim 9 wherein the pressure distribution article includes an oxygen-carrying medium.
13. The compression exertion device of claim 9 wherein at least a portion of the pressure distribution article is made from a material having an open pore structure extending through a thickness thereof.
14. The compression exertion device of claim 4 further comprising:
at least one sensor at least one of attached to and in functional contact with at least one of outer enclosure, the cavity partition, the body part engaging seal component, and the pressure distribution article, wherein the at least one sensor is operable to enable monitoring at least one of compressive pressure, blood oxygen, and blood flow and adjusting the compressive pressure to mitigate peripheral nerve neuropathy resulting from reduced blood flow within at least a portion of the body part.
15. The compression exertion device of claim 3 , further comprising:
an outer body at an exterior surface of the outer enclosure, wherein the outer body constrains expansion of the outer enclosure during said pressurization of the compression exertion device.
16. The compression exertion device of claim 3 wherein the compression inducing medium is one of a thermally-conditioned gas and thermally-conditioned liquid.