IP Library Granted Patent US 11,872,068
Granted Patent B2
US 11,872,068 · App. 17/290,815 · Granted Jan 16, 2024

Pulsed X-ray imaging

Inventors: Rejean Fontaine (Sherbrooke, CA); Julien Rossignol (Sherbrooke, CA); Yves Bérubé-Lauzière (Sherbrooke, CA)
A61B6/483A61B6/4085A61B6/4241G01T1/17H01J35/065H05G1/085
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Quick Facts
Patent No.
US 11,872,068
App. No.
17/290,815
Granted
Jan 16, 2024
Kind
B2
Abstract

The X-ray imager combines a pulsed X-ray source with a time-sensitive X-ray detector to provide a measure of ballistic photons with a reduction of scattered photons. The imager can provide a comparable contrast-to-noise X-ray image using significantly less radiation exposure than conventional X-ray imagers, notably about half of the radiation.

Claims (37)

1. An X-ray imaging apparatus comprising:

a pulsed X-ray source having a control signal, wherein said pulsed X-ray source produces a fan or a cone shaped beam;

a time-sensitive X-ray detector having a time-dependent X-ray photon detection signal output and for one of:

providing for each photon detected at each pixel element a time of detection signal; and

being responsive to a gate signal controlling a time when photon detection is enabled or disabled;

wherein said time-sensitive X-ray detector comprises an X-ray sensitive scintillator and a light sensor array coupled with said scintillator for measuring X-ray detection events in said scintillator;

a processor, connected to said control signal and said time-dependent X-ray photon detection signal output, having an output for providing a measure of ballistic photons with a reduction in a measurement of scattered photons received by said time-sensitive detector;

wherein said time-sensitive X-ray detector is arranged with respect to said pulsed X-ray source so as to provide a different time of flight for said ballistic photons as a function of a pixel location within said time-sensitive X-ray detector; and

wherein said processor provides said measure of ballistic photons with said reduction in the measurement of scattered photons received by said time-sensitive detector using different timing as a function of location of said pixels.

2. The apparatus as defined in claim 1 , wherein said pulsed X-ray source comprises a high voltage source, electrodes connected to said high voltage source for accelerating electrons, and an X-ray emitting target material arranged to receive said electrons following acceleration by said electrodes so as to produce a pulse of X-rays.

3. The apparatus as defined in claim 2 , wherein said pulsed X-ray source comprises:

a pulsed laser source responsive to said control signal;

a photoelectric material arranged to receive a light pulse from said pulsed laser source and to emit a burst of electrons in response thereto;

wherein electrodes are arranged to accelerate said burst of electrons.

4. The apparatus as defined in claim 3 , wherein said photoelectric material is at least a part of a cathode of said electrodes.

5. The apparatus as defined in claim 2 , wherein said pulsed X-ray source comprises deflection electrodes for steering said electrons accelerated by said electrodes connected to said high voltage source to controllably hit said X-ray emitting target material.

6. The apparatus as defined in claim 2 , wherein said electrodes connected to said high voltage source comprise a gated carbon nanotube cathode.

7. The apparatus as defined in claim 1 , wherein said time- sensitive X-ray detector is responsive to a gate signal controlling a time when photon detection is enabled or disabled, and said processor collects, when in use, X-ray photons detected within different time frames with respect to said control signal and determine said measure of ballistic photons with a reduction in the measurement of scattered photons received by said time-sensitive detector through subtraction of said X-ray photons detected within different time frames.

8. The apparatus as defined in claim 1 , wherein said gate signal controlling said time when photon detection is enabled or disabled is a pulsed gate signal.

9. The apparatus as defined in claim 1 , wherein said apparatus is operative to obtain an image with a given contrast to noise ratio (CNR) while delivering a dosage of X-rays to a typical human abdominal region of at least 20 cm thickness that is at least 50% less than when-said time-sensitive X-ray detector and said processor having an output for providing, when in use, a measure both ballistic and scattered photons without a reduction in the measurement of scattered photons from said pulsed X-ray source.

10. The apparatus as defined in claim 9 , wherein said delivered dosage of said X-rays to said typical human abdominal region is at least 50% lower.

11. The apparatus as defined in claim 1 , wherein said pulsed X-ray source produces a cone beam and said a time-sensitive X-ray detector is arranged to detect a 2D array of pixels.

12. The apparatus as defined in claim 1 , wherein a rise time of a pulse emitted by said pulsed X-ray source is less than 0.15 nanoseconds, and a response time of a combination of said pulsed X-ray source and said time-sensitive detector is less than 0.9 nanoseconds.

13. The apparatus as defined in claim 1 , wherein said processor for measuring an impulse response time of a combination of said pulsed X-ray source and said time-sensitive detector to obtain a measure of ballistic photons without an object or patient between said pulsed X-ray source and said time-sensitive detector and to derive therefrom and store in memory a gate parameter for said measure of ballistic photons with a reduction in the measurement of scattered photons received by said time-sensitive detector when thereafter measuring objects or patients that provide scatter.

14. A method of acquiring a medical diagnostic image of a human patient comprising using an apparatus as defined in claim 1 to obtain an image of a region of interest and having a contrast-to-noise ratio using X-rays of a given energy, wherein an amount of radiation delivered to said patient is about 60% or less of an amount of radiation delivered to a same patient for continuous, polychromatic X-ray imaging of said region of interest using said given energy of X-rays.

15. The method as defined in claim 14 , wherein said amount of radiation delivered to said patient is about 30% or less of an amount of radiation delivered to a same patient for continuous, polychromatic X-ray imaging of said region of interest using said given energy of X-rays.

16. The apparatus as defined in claim 1 , wherein a rise time of a pulse emitted by said pulsed X-ray source is less than 0.15 nanoseconds, and a response time of a combination of said pulsed X-ray source and said time-sensitive detector is less than 0.3 nanoseconds.

17. An X-ray imaging apparatus comprising:

a pulsed X-ray source having a control signal;

a time-sensitive X-ray detector having a time-dependent X-ray photon detection signal output;

a processor, connected to said control signal and said time-dependent X-ray photon detection signal output, having an output for providing, when in use, a measure of ballistic photons with a reduction in a measurement of scattered photons received by said time-sensitive detector; and

wherein said time-sensitive X-ray detector is arranged with respect to said pulsed X-ray source so as to provide a different time of flight for said ballistic photons as a function of a pixel location within said time-sensitive X-ray detector, wherein said processor provides said measure of ballistic photons with said reduction in the measurement of scattered photons received by said time-sensitive detector using different timing as a function of location of said pixels.

18. An X-ray imaging apparatus comprising:

a pulsed X-ray source having a control signal;

a time-sensitive X-ray detector having a time-dependent X-ray photon detection signal output;

a processor, connected to said control signal and said time-dependent X-ray photon detection signal output, having an output for providing a measure of ballistic photons with a reduction in a measurement of scattered photons received by said time-sensitive detector and to generate a 2D and/or a 3D image from said measure;

wherein said apparatus is operative to obtain said image with a given contrast to noise ratio (CNR) while delivering a dosage of X-rays that is at least 30% lower to a typical human abdominal region of at least 20 cm thickness than when continuous X-rays of a same energy are used in a similarly-structured continuous X-ray imaging apparatus.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 3, 2021
From: FONTAINE, REJEAN; ROSSIGNOL, JULIEN; BÉRUBÉ-LAUZIÈRE, YVES
To: UNIVERSITÉ DE SHERBROOKE
Reel/Frame 056117/0433 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 3, 2021
From: UNIVERSITÉ DE SHERBROOKE
To: SOCPRA SCIENCES ET GÉNIE S.E.C.
Reel/Frame 056117/0565 →
Continuity (2)
Provisional Application 62755813 · Nov 5, 2018
Related Publication 20210369222A1 · Dec 2, 2021