Patches for localized use

1. A device comprising a patch comprising:

(i) a substrate, wherein the substrate is selected from the group consisting of ethane-acetic acid ethenyl ester, polyvinyl alcohol, ethyl cellulose, Polylactic acid, poly-ε-caprolactone (PCL) film and triglycidylamine;

(ii) an adhesive on the substrate, wherein the adhesive is selected from the group consisting of an epoxyamine, methyl acrylate, ethyl acrylate, ethyl methacrylate, methyl methacrylate, n-butyl acrylate, n-butyl methacrylate, n-pentyl acrylate, n-hexyl acrylate, n-heptyl acrylate, and n-octyl acrylate, and a branched (meth)acrylic isomer selected from i-butyl acrylate, i-butyl methacrylate, n-butyl methacrylate, 2-ethylhexyl acrylate, stearyl methacrylate or isooctyl acrylate;

(iii) a pocket under the substrate prefilled with a first material and a second material, wherein the first material is a combination of penetration enhancer and dye; wherein the penetration enhancer is selected from the group consisting of ethanol, isopropyl alcohol, decanol, hexanol, lauryl alcohol, myristyl alcohol, octanol, octyl dodecanol, oleyl alcohol;

(iv) an opening in the substrate, and

(v) a flap, wherein the flap covers the opening and is different than the substrate, and is configured for the introduction of materials in the patch; and

wherein the patch is configured to:

(a) attach to a skin via the adhesive to form the pocket between the patch and a skin, wherein the adhesive circumscribes the pocket,

(b) allow introduction of a second material into the pocket through the opening, and

(c) hold the first material and the second material within the pocket;

wherein the first material is configured to activate under a specific condition by reacting the first material with the second material; wherein the device is configured to image a portion of the skin on which the patch is placed.

2. The device of claim 1 , wherein the device further comprises a peelable liner.

3. The device of claim 2 , wherein the peelable liner is below the patch and attached to the patch via the adhesive to form the pocket between the patch and the peelable liner.

4. The device of claim 1 , wherein the flap comprises a net structure to hold a surface tension of a liquid.

5. The device of claim 1 , wherein the substrate and the adhesive are compatible with the first material and the second material.

6. The device of claim 1 , wherein the substrate and the adhesive are compatible with DMSO.

7. The device of claim 1 , wherein the substrate is flexible.

8. The device of claim 1 , wherein the dye comprises a molecular dye, a tag, a nanoparticle, a radionucleotide, or a combination thereof.

9. The device of claim 1 , wherein the pocket comprises a space or a pattern.

10. The device of claim 1 , wherein the opening comprises a protrusion or a tubular structure.

11. The device of claim 10 , wherein said protrusion or said tubular structure comprises a clamp configured to open or close the opening.

12. The device of claim 1 , wherein the patch is configured to allow a skin-substance to emerge from the skin into the patch.

13. The device of claim 1 , wherein the specific condition comprises an ionizing radiation.

14. The device of claim 1 , wherein the activation of the first material allows the first material to react with the skin for imaging of the skin.

15. The device of claim 1 , further comprising a heat pouch within the patch configured to heat the patch.

16. The device of claim 1 , wherein the patch is configured to hold a material inside the pocket by a surface tension.