Hydroxypropyl methyl cellulose phthalate and method for producing the same
There is provided a method for producing hydroxypropyl methyl cellulose phthalate (HPMCP), including an esterification step of reacting hydroxypropyl methyl cellulose with a carboxybenzoylating agent in the presence of an aliphatic carboxylic acid in a kneader reactor equipped with two or more stirring blades rotating around their own axes and orbitally revolving, to obtain a reaction product solution containing HPMCP; a precipitation step of precipitating the HPMCP by mixing the reaction product solution with water to obtain a suspension of the precipitated HPMCP; and a washing and recovery step of washing the HPMCP in the suspension and recovering the washed HPMCP. Further, there is provided HPMCP having yellowness at 20° C. of 10.0 or less, as determined in a 10% by mass solution of the HPMCP in acetone.
1. A method for producing hydroxypropyl methyl cellulose phthalate comprising:
an esterification step of reacting hydroxypropyl methyl cellulose with a carboxybenzoylating agent in the presence of an aliphatic carboxylic acid in a kneader reactor equipped with two or more stirring blades rotating around their own axes and orbitally revolving, to obtain a reaction product solution containing hydroxypropyl methyl cellulose phthalate;
a precipitation step of precipitating the hydroxypropyl methyl cellulose phthalate by mixing the reaction product solution with water to obtain a suspension of the precipitated hydroxypropyl methyl cellulose phthalate; and
a washing and recovering step of washing the hydroxypropyl methyl cellulose phthalate in the suspension and recovering the washed hydroxypropyl methyl cellulose phthalate.
2. The method for producing the hydroxypropyl methyl cellulose phthalate according to claim 1 , wherein a shape of each of the stirring blades is selected from the group consisting of a frame, a turbine, a ribbon, and an anchor wing.