IP Library › Granted Patent US 11,874,240
Granted Patent B2
US 11,874,240 · App. 17/282,206 · Granted Jan 16, 2024

Systems and methods for interpreting high energy interactions

Inventor: Brandon Lee Goodchild Drake (Greeley, CO)
Assignees: Decision Tree, LLC; Veracio Ltd.
G01N23/223G01N23/2076G06F18/214G06F18/24G06N20/00
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Quick Facts
Patent No.
US 11,874,240
App. No.
17/282,206
Granted
Jan 16, 2024
Kind
B2
Abstract

Systems and methods for interpreting high-energy interactions on a sample are described in this application. In particular, this application describes an analysis method that comprises impinging radiation from a source on an analyte, detecting the energy interactions resulting from the impinging radiation using a radiation detector, adjusting the signal from the radiation detector using a machine learning module to emphasize specific parts of the detector signal, training the machine learning module in a supervised or unsupervised manner, producing quantitative and qualitative models using the machine leaning module, and then applying the machine learning module to additional energy interactions. The signal received by the detector can be preprocessed to emphasize specific parts of the detector signal, which is then mapped to a machine learning module for training in a supervised or unsupervised manner. The quantitative and qualitative models derived from this training can be applied to new detector inputs from the same or similar instruments. Other embodiments are described.

Claims (40)

1. An analysis method, comprising:

impinging radiation from a source on an analyte;

detecting energy interactions resulting from the impinging radiation using a radiation detector, wherein the radiation detector produces a signal indicative of the detected energy interactions;

adjusting the signal from the radiation detector using a machine learning module to emphasize specific parts of the signal;

training the machine learning module in a supervised or unsupervised manner;

producing quantitative and qualitative models using the machine leaning module; and

applying the machine learning module to additional energy interactions.

2. The method of claim 1 , wherein the machine learning module uses existing measurements, wherein the existing measurements comprise compositional data about the analyte though empirical measurements or estimated values, membership of the analyte in a class, or a known energy peak for a material of the analyte.

3. The method of claim 1 , wherein the signal is determined by a counting mechanism within the radiation detector that provides data in a continuous interval, which can be used either in a full or summarized form by the machine learning module.

4. The method of claim 1 , further comprising a normalization or data pre-processing step that adjusts detector counts to highlight distinctive features for input mapping into the machine learning module.

5. The method of claim 1 , wherein the machine-learning module uses one or more algorithms to identify relationships in the signal of the detector, wherein the relationships in the signal of the detector comprise random forests, gradient boosting, support vector machines, neural networks, or k-nearest neighbors.

6. The method of claim 1 , wherein the machine learning module provides an output having fluorescent peaks that are guided by relationships within the signal from the radiation detector.

7. The method of claim 1 , wherein detecting energy interactions resulting from the impinging radiation using a radiation detector;

wherein the machine learning module is trained in a supervised manner, wherein the radiation detector is a first radiation detector, and wherein information from at least a second radiation detector used as a part of supervised training of the machine learning module.

8. The method of claim 1 , wherein the radiation comprises photons, and wherein the photons have ionizing effects on the analyte.

9. The method of claim 8 , wherein the signal of the detector that is input into the machine learning module is indicative of photon-fermion interactions that are not the product of ionization.

10. The method of claim 1 , wherein the additional energy interactions result from impinging radiation on an analyte, and wherein the method further comprises applying the quantitative and qualitative models during analysis of the additional energy interactions.

11. The method of claim 10 , wherein the radiation detector that produces the signal is a first radiation detector, and wherein the additional energy interactions are detected by a second radiation detector that produces a second signal indicative of the additional energy interactions.

12. The method of claim 1 , wherein the radiation comprises charged particles, and wherein the charged particles include photons, electrons, or protons with the ability to ionize the analyte.

13. The method of claim 1 , wherein the source is an X-ray source, and wherein the radiation detector is an X-ray detector.

14. The method of claim 13 , wherein signal of the X-ray detector is indicative of the fluorescent X-ray emitted from the analyte, and wherein the machine learning module determines a chemistry of the analyte.

15. The method of claim 1 , wherein the signal is indicative of fluorescence peaks, background radiation scatter, coherent (Bragg) scattering, inelastic (Compton) scattering, or elastic (Rayleigh) scattering.

16. The method of claim 15 , wherein the machine learning module provides an output showing energy spectra of elements that are present in the analyte.

17. The method of claim 16 , wherein the machine learning module provides the output to a remote computing device.

18. An analysis method, comprising:

using a radiation detector to detect energy interactions resulting from radiation impinging on an analyte, wherein the radiation detector produces a signal indicative of the detected energy interactions;

adjusting the signal from the radiation detector using a machine learning module to emphasize specific parts of the signal;

training the machine learning module in a supervised or unsupervised manner;

producing quantitative and qualitative models using the machine leaning module; and

applying the machine learning module to additional energy interactions.

19. An analysis system, comprising:

a radiation source;

a radiation detector; and

a machine learning module configured to:

receive a signal from the radiation detector, the signal being indicative of detected energy interactions from radiation impinging on an analyte;

adjust the signal to emphasize specific parts of the signal;

train itself in a supervised or unsupervised manner; and

produce quantitative and qualitative models.

20. The analysis system of claim 19 , wherein the machine leaning module is further configured to apply the quantitative and qualitative models to additional energy interactions.

21. The analysis system of claim 20 , wherein the radiation source is an X-ray source, and wherein the radiation detector is an X-ray detector.

Assignments (3)
CORRECTIVE ASSIGNMENT TO CORRECT THE CONVEYING PARTY DATA PREVIOUSLY RECORDED ON REEL 65784 FRAME 128. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Jul 18, 2025
From: DRAKE, BRANDON LEE GOODCHILD
To: DECISION TREE, LLC; VERACIO LTD.
Reel/Frame 072066/0306 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 6, 2023
From: DECISION TREE, LLC
To: DECISION TREE, LLC; VERACIO LTD.
Reel/Frame 065784/0128 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 18, 2021
From: DRAKE, BRANDON LEE GOODCHILD
To: DECISION TREE, LLC
Reel/Frame 057815/0841 →
Continuity (2)
Provisional Application 62741231 · Oct 4, 2018
Related Publication 20210341400A1 · Nov 4, 2021
Cited By (1)
US 12,292,398