Compositions comprising an urolithin compound
The invention provides compositions comprising a source of protein and a urolithin. The invention also provides uses and methods associated with, or making use of the compositions, such as a medicament, dietary supplement, functional food or medical food and in the treatment and/or prophylaxis of a muscle-related pathological condition. The invention also provides kits comprising urolithin and protein.
1. A method of improving physical performance, comprising administering to a subject in need thereof an effective amount of a composition comprising a urolithin and a source of protein; wherein the physical performance is walking or running.
2. The method of claim 1 , wherein the subject's performance in the six-minute walk test (MWT) is improved.
3. The method of claim 1 , wherein the subject's time to walk a certain distance (gait speed) is improved.
4. The method of claim 1 , wherein the subject's time to run a certain distance (running speed) is improved.
5. The method of claim 1 , wherein the subject's running economy is improved.
6. The method of claim 1 , wherein the subject's International Physical Activity Questionnaire (IPAQ) score is improved.
7. The method of claim 1 , wherein the subject's number of chair-stands in a certain time is increased.
8. A method of improving muscle function, comprising administering to a subject in need thereof an effective amount of a composition comprising a urolithin and a source of protein; wherein the muscle function is muscle endurance.
9. The method of claim 8 , wherein the subject's muscular contraction strength is increased.
10. The method of claim 8 , wherein the subject's amplitude of muscle contracting is increased.
11. The method of claim 8 , wherein subject's muscle reaction time between stimulation and contraction is shortened.
12. The method of claim 8 , wherein the subject's upper body and/or lower body muscle endurance is improved.
13. The method of claim 12 , wherein the subject's hand grip strength is improved.
14. The method of claim 8 , wherein the subject's skeletal muscle respiratory capacity is increased.
15. The method of claim 14 , wherein the subject's maximal oxygen consumption (VO 2 max ) is increased.
16. The method of claim 8 , wherein the subject's muscle mass is increased.
17. The method of claim 8 , wherein the subject's muscle stem cell regenerative ability is improved.
18. A method of improving physical performance, comprising administering to a subject in need thereof an effective amount of a composition comprising urolithin A and a source of protein.
19. The method of claim 18 , wherein the physical performance is walking or running.
20. A method of improving muscle function, comprising administering to a subject in need thereof an effective amount of a composition comprising urolithin A and a source of protein.
21. The method of claim 20 , wherein the muscle function is muscle endurance.