Substituted heterocyclic compounds
There are disclosed compounds of the following formula I: or a stereoisomer or pharmaceutically acceptable salt thereof, wherein all substituents are as defined herein, which are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition. The compounds of the invention may be useful for treating neurodegenerative diseases or disorders.
1. A compound of formula I
or a stereoisomer or pharmaceutically acceptable salt thereof,
wherein
X is —N— or —CH—;
R 1 is —C(O)R 1a ;
R 1a is C 3-6 cycloalkyl;
R 2 is C 1-6 alkoxy;
R 3 is C 1-6 alkyl or C 3-6 cycloalkyl.
2. The compound according to claim 1 of the formula
or a stereoisomer or pharmaceutically acceptable salt thereof,
wherein
R 1 is —C(O)R 1a ;
R 1a is C 3-6 cycloalkyl;
R 2 is C 1-6 alkoxy;
R 3 is C 1-6 alkyl or C 3-6 cycloalkyl.
3. The compound according to claim 1 of the formula
or a stereoisomer or pharmaceutically acceptable salt thereof,
wherein
R 1 is —C(O)R 1a ;
R 1a is C 3-6 cycloalkyl;
R 2 is C 1-6 alkoxy;
R 3 is C 1-6 alkyl or C 3-6 cycloalkyl.
4. A compound or a pharmaceutically acceptable salt thereof, selected from
N-(4-((3-methoxy-4-(2-methyl-2H-1,2,3-triazol-4-yl)pyridin-2-yl)amino)-5-propionylpyridin-2-yl)cyclopropanecarboxamide,
N-(4-((3-methoxy-4-(2-cyclopropyl-2H-1,2,3-triazol-4-yl)pyridin-2-yl)amino)-5-propionylpyridin-2-yl)cyclopropanecarboxamide,
N-(4-((2-methoxy-3-(2-methyl-2H-1,2,3-triazol-4-yl)phenyl)amino)-5-propionylpyridin-2-yl)cyclopropanecarboxamide,
N-(4-((4-fluoro-2-methoxy-3-(2-methyl-2H-1,2,3-triazol-4-yl)phenyl)amino)-5-propionylpyridin-2-yl)cyclopropanecarboxamide,
N-(4-((3-fluoro-2-methoxy-3-(2-methyl-2H-1,2,3-triazol-4-yl)phenyl)amino)-5-propionylpyridin-2-yl)cyclopropanecarboxamide, and
N-(4-((3-methyl-2-methoxy-3-(2-methyl-2H-1,2,3-triazol-4-yl)phenyl)amino)-5-propionylpyridin-2-yl)cyclopropanecarboxamide.
5. A pharmaceutical composition comprising one or more compounds according to claim 1 and a pharmaceutically acceptable carrier or diluent.
6. A pharmaceutical composition comprising one or more compounds according to claim 4 and a pharmaceutically acceptable carrier or diluent.