IKAROS zinc finger family degraders and uses thereof
The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.
1. A compound of the formula:
or a pharmaceutically acceptable salt thereof.
2. The compound or pharmaceutically acceptable salt thereof of claim 1 , wherein the compound is
3. The compound or pharmaceutically acceptable salt thereof of claim 1 , wherein the compound is
4. The compound or pharmaceutically acceptable salt thereof of claim 1 , wherein the compound is
5. The compound or pharmaceutically acceptable salt thereof of claim 1 , wherein the compound is
6. The compound or pharmaceutically acceptable salt thereof of claim 1 , wherein the compound is
7. The compound or pharmaceutically acceptable salt thereof of claim 1 , wherein the compound is
8. The compound or pharmaceutically acceptable salt thereof of claim 1 , wherein the compound is
9. The compound or pharmaceutically acceptable salt thereof of claim 1 , wherein the compound is
10. The compound or pharmaceutically acceptable salt thereof of claim 1 , wherein the compound is