Eye drop composition
The present invention relates to an eye-drop composition comprising 2-amino-9-[[(1S,2R)-1,2-bis(hydroxymethyl)cyclopropyl]methyl]-1,9-dihydro-6H-Purin-6-one, and the use thereof for the diagnosis and treatment of herpetic eye infections in companion animals.
1. A composition comprising:
at least 0.1% w/v 2-amino-9-[[(1S,2R)-1,2-bis(hydroxymethyl)cyclopropyl]methyl]-1,9-dihydro-6H-Purin-6-one; and
at least 10% w/v of a cyclodextrin.
2. The composition according to claim 1 , which is an aqueous solution.
3. The composition according to claim 1 , wherein said composition is an ophthalmic solution.
4. The composition according to claim 1 , wherein said cyclodextrin is hydroxypropyl beta-cyclodextrin.
5. The composition according to claim 1 , further comprising at least 0.008% w/v thiomersal.
6. A composition according to claim 1 , for use as a diagnostic or a therapeutic composition.
7. The composition according to claim 6 , for use in a method for the treatment of an ocular herpetic infection.
8. The composition according to claim 7 , wherein said ocular infection is an ocular infection of a companion animal.
9. The composition according to claim 8 , wherein said companion animal is a feline.
10. The composition according to claim 7 , wherein said method comprises applying said composition onto the eye two or three times per day for at least seven days.
11. The composition according to claim 6 , for use in a method of diagnosis of an ocular herpetic infection.
12. The composition according to claim 10 , wherein said ocular infection is an ocular infection in a companion animal.
13. The composition according to claim 12 , wherein said companion animal is a feline.
14. A method for preparing an ophthalmic solution, comprising the steps of:
a) providing a solution comprising at least 10% w/v of a cyclodextrin;
b) adding 2-amino-9-[[(1S,2R)-1,2-bis(hydroxymethyl)cyclopropyl]methyl]-1,9-dihydro-6H-Purin-6-one to said solution;
c) solubilizing the 2-amino-9-[[(1S,2R)-1,2-bis(hydroxymethyl)cyclopropyl]methyl]-1,9-dihydro-6H-Purin-6-one added in step b);
d) repeating steps b) and c) until a concentration of 2-amino-9-[[(1S,2R)-1,2-bis(hydroxymethyl)cyclopropyl]methyl]-1,9-dihydro-6H-Purin-6-one in said solution of at least 1 mg/mL is obtained;
e) optionally, adding at least 0.008 mg/mL thiomersal.
15. The method according to claim 14 , wherein said cyclodextrin is hydroxypropyl beta-cyclodextrin.