Macrocyclic heterocycles and uses thereof

1. A compound of the formula:

or a pharmaceutically acceptable salt or solvate thereof, wherein:

is selected from C 5-7 carbocycle and 5- to 7-membered heterocycle, each of which is optionally substituted with one or more R 11 ;

is absent or selected from C 3-8 carbocycle and 3- to 8-membered heterocycle, each of which is optionally substituted with one or more R 11a ;

L 1 is selected from a bond, C 1-6 alkylene, and C 1-6 haloalkylene;

L 2 is selected from C 5-25 alkylene, C 5-25 alkenylene, C 5-25 alkynylene, 5- to 25-membered heteroalkylene, and 5- to 25-membered heteroalkenylene, each of which is optionally substituted with one or more R 11b , wherein L 2 is covalently bound to one of W 3 , W 4 , W 5 , W 6 , or W 7 ;

W 3 is selected from N(R 3b ), N, C(R 3 ), and C(O);

W 4 is selected from N(R 4b ), N, C(R 4 ), and C(O);

W 5 is selected from N(R 5b ), N, and C(R 5 );

W 6 is selected from C(R 6 ) and C(O);

W 7 is C(R 7 );

R 1 is C 1-3 alkyl optionally substituted with one or more R 11c ;

R 8 is selected from hydrogen, halogen, —CN, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 carbocycle, 3- to 10-membered heterocycle, —OR 12 , —SR 12 , —N(R 12 )(R 13 ), —C(O)OR 12 , —OC(O)N(R 12 )(R 13 ), —N(R 14 )C(O)N(R 12 )(R 13 ), —N(R 14 )C(O)OR 15 , —N(R 14 )S(O) 2 R 15 , —C(O)R 15 , —S(O)R 15 , —OC(O)R 15 , —C(O)N(R 12 )(R 13 ), —C(O)C(O)N(R 12 )(R 13 ), —N(R 14 )C(O)R 15 , —S(O) 2 R 15 , —S(O) 2 N(R 12 )(R 13 ), —S(═O)(═NH)N(R 12 )(R 13 ), —CH 2 C(O)N(R 12 )(R 13 ), —CH 2 N(R 14 )C(O)R 15 , —CH 2 S(O) 2 R 15 , and —CH 2 S(O) 2 N(R 12 )(R 13 ), wherein each C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 carbocycle, and 3- to 10-membered heterocycle is independently optionally substituted with one, two, or three R 20 ;

R 3 , R 4 , R 5 , R 6 , and R 7 are each independently selected from a bond to L 2 , hydrogen, halogen, —CN, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 carbocycle, 3- to 10-membered heterocycle, —OR 12 , —SR 12 , —N(R 12 )(R 13 ), —C(O)OR 12 , —OC(O)N(R 12 )(R 13 ), —N(R 14 )C(O)N(R 12 )(R 13 ), —N(R 14 )C(O)OR 15 , —N(R 14 )S(O) 2 R 15 , —C(O)R 15 , —S(O)R 15 , —OC(O)R 15 , —C(O)N(R 12 )(R 13 ), —C(O)C(O)N(R 12 )(R 13 ), —N(R 14 )C(O)R 15 , —S(O) 2 R 15 , —S(O) 2 N(R 12 )(R 13 ), —S(═O)(═NH)N(R 12 )(R 13 ), —CH 2 C(O)N(R 12 )(R 13 ), —CH 2 N(R 14 )C(O)R 15 , —CH 2 S(O) 2 R 15 , and -CH 2 S(O) 2 N(R 12 )(R 13 ), wherein each C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 carbocycle, and 3- to 10-membered heterocycle is independently optionally substituted with one, two, or three R 20 ;

R 3b , R 4b , and R 5b are each independently selected from a bond to L 2 , hydrogen, —CN, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 carbocycle, 3- to 10-membered heterocycle, —OR 12 , —SR 12 , —C(O)OR 12 , —OC(O)N(R 12 )(R 13 ), —C(O)R 15 , —S(O)R 15 , —OC(O)R 15 , —C(O)N(R 12 )(R 13 ), —C(O)C(O)N(R 12 )(R 13 ), —S(O) 2 R 15 , —S(O) 2 N(R 12 )(R 13 ), —S(═O)(═NH)N(R 12 )(R 13 ), —CH 2 C(O)N(R 12 )(R 13 ), —CH 2 N(R 14 )C(O)R 15 , —CH 2 S(O) 2 R 15 , and —CH 2 S(O) 2 N(R 12 )(R 13 ), wherein each C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 carbocycle and 3- to 10-membered heterocycle is independently optionally substituted with one, two, or three R 20 ;

R 11 and R 11a are each independently selected at each occurrence from halogen, —CN, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 carbocycle, 3- to 10-membered heterocycle, —OR 12 , —SR 12 , —N(R 12 )(R 13 ), —C(O)OR 12 , —OC(O)N(R 12 )(R 13 ), —N(R 14 )C(O)N(R 12 )(R 13 ), —N(R 14 )C(O)OR 15 , —N(R 14 )S(O) 2 R 15 , —C(O)R 15 , —S(O)R 15 , —OC(O)R 15 , —C(O)N(R 12 )(R 13 ), —C(O)C(O)N(R 12 )(R 13 ), —N(R 14 )C(O)R 15 , —S(O) 2 R 15 , —S(O) 2 N(R 12 )(R 13 ), —S(═O)(═NH)N(R 12 )(R 13 ), —CH 2 C(O)N(R 12 )(R 13 ), —CH 2 N(R 14 )C(O)R 15 , —CH 2 S(O) 2 R 15 , —CH 2 S(O) 2 N(R 12 )(R 13 ), —CH 2 N(R 12 )S(O) 2 (R 13 ), and —P(O)(R 17 )(R 17a ), wherein C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 carbocycle, and 3- to 10-membered heterocycle are optionally substituted with one, two, or three R 20 ;

R 11b is independently selected at each occurrence from halogen, oxo, —CN, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 carbocycle, 3- to 10-membered heterocycle, —OR 12 , —SR 12 , —N(R 12 )(R 13 ), —C(O)OR 12 , —OC(O)N(R 12 )(R 13 ), —N(R 14 )C(O)N(R 12 )(R 13 ), —N(R 14 )C(O)OR 15 , —N(R 14 )S(O) 2 R 15 , —C(O)R 15 , —S(O)R 15 , —OC(O)R 15 , —C(O)N(R 12 )(R 13 ), —C(O)C(O)N(R 12 )(R 13 ), —N(R 14 )C(O)R 15 , —S(O) 2 R 15 , —S(O) 2 N(R 12 )(R 13 ), —S(═O)(═NH)N(R 12 )(R 13 ), —CH 2 C(O)N(R 12 )(R 13 ), —CH 2 N(R 14 )C(O)R 15 , —CH 2 S(O) 2 R 15 , —CH 2 S(O) 2 N(R 12 )(R 13 ), —CH 2 N(R 12 )S(O) 2 (R 13 ), and —P(O)(R 17 )(R 17a ), wherein C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 carbocycle, and 3- to 10-membered heterocycle are optionally substituted with one, two, or three R 20 ;

R 11c is independently selected at each occurrence from halogen, —OR 12 , and —N(R 12 )(R 13 );

R 12 is independently selected at each occurrence from hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 carbocycle, and 3- to 10-membered heterocycle, wherein C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 carbocycle, and 3- to 10-membered heterocycle are optionally substituted with one, two, or three R 20 ;

R 13 is independently selected at each occurrence from hydrogen, C 1-6 alkyl, and C 1-6 haloalkyl; or R 12 and R 13 , together with the nitrogen atom to which they are attached, form a 3- to 10-membered heterocycle optionally substituted with one, two, or three R 20 ;

R 14 is independently selected at each occurrence from hydrogen, C 1-6 alkyl, and C 1-6 haloalkyl;

R 15 is independently selected at each occurrence from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 carbocycle, and 3- to 10-membered heterocycle, wherein C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 carbocycle, and 3- to 10-membered heterocycle are optionally substituted with one, two, or three R 20 ;

R 17 and R 17a are each independently selected at each occurrence from C 1-6 alkyl and C 3-6 cycloalkyl, wherein C 1-6 alkyl and C 3-6 cycloalkyl are optionally substituted with one, two or three R 20 ; or R 17 and R 17a , together with the phosphorous atom to which they are attached, form a 3- to 10-membered heterocycle;

R 20 is independently selected at each occurrence from halogen, oxo, ═NH, —CN, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 carbocycle, —CH 2 -(C 3-10 carbocycle), 3- to 10-membered heterocycle, —CH 2 -(3- to 10-membered heterocycle), —OR 21 , —SR 21 , —N(R 22 )(R 23 ), —C(O)OR 22 , —C(O)N(R 22 )(R 23 ), —C(O)C(O)N(R 22 )(R 23 ), —OC(O)N(R 22 )(R 23 ), —N(R 24 )C(O)N(R 22 )(R 23 ), —N(R 24 )C(O)OR 25 , —N(R 24 )C(O)R 25 , —N(R 24 )S(O) 2 R 25 , —C(O)R 25 , —S(O) 2 R 25 , —S(O) 2 N(R 22 )(R 23 ), —OCH 2 C(O)OR 22 , and —OC(O)R 25 , wherein C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 carbocycle, —CH 2 -(C 3-10 carbocycle), 3- to 10-membered heterocycle, and —CH 2 -(3- to 10-membered heterocycle) are optionally substituted with one, two, or three groups independently selected from halogen, oxo, ═NH, —CN, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 haloalkoxy, —OR 21 , —SR 21 , —N(R 22 )(R 23 ), —C(O)OR 22 , —C(O)N(R 22 )(R 23 ), —C(O)C(O)N(R 22 )(R 23 ), —OC(O)N(R 22 )(R 23 ), —N(R 24 )C(O)N(R 22 )(R 23 ), —N(R 24 )C(O)OR 25 , —N(R 24 )C(O)R 25 , —N(R 24 )S(O) 2 R 25 , —C(O)R 25 , —S(O) 2 R 25 , —S(O) 2 N(R 22 )(R 23 ), and —OC(O)R 25 ;

R 21 is independently selected at each occurrence from H, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 carbocycle, and 3- to 10-membered heterocycle, wherein C 3-10 carbocycle and 3- to 10-membered heterocycle are optionally substituted with one, two, or three groups independently selected from halogen and C 1-6 alkyl;

R 22 is independently selected at each occurrence from H, C 1-6 alkyl, C 1-6 haloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 carbocycle, and 3- to 10-membered heterocycle, wherein C 3-10 carbocycle and 3- to 10-membered heterocycle are optionally substituted with one, two, or three groups independently selected from halogen and C 1-6 alkyl;

R 23 is independently selected at each occurrence from H and C 1-6 alkyl;

R 24 is independently selected at each occurrence from H and C 1-6 alkyl;

R 25 is independently selected at each occurrence from C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-10 carbocycle, and 3- to 10-membered heterocycle, wherein C 1-6 alkyl, C 3-10 carbocycle, and 3- to 10-membered heterocycle are optionally substituted with one, two, or three groups independently selected from halogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 3-10 carbocycle, and 3- to 10-membered heterocycle; and

indicates a single or double bond such that all valences are satisfied.

2. The compound of claim 1 having the structure of Formula (I-B1) or (I-B2):

or a pharmaceutically acceptable salt or solvate thereof.

3. The compound of claim 1 having the structure of Formula (I-C1), (I-C2), or (I-C3):

or a pharmaceutically acceptable salt or solvate thereof.

4. The compound, salt, or solvate of claim 1 , wherein R 1 is —CH 3 .

5. The compound, salt, or solvate of claim 1 , wherein R 3 is selected from hydrogen, —CN, —OR 12 , and —CH 3 .

6. The compound, salt, or solvate of claim 1 , wherein R 6 is selected from hydrogen, —OR 12 , and C 1-6 alkyl optionally substituted with one, two, or three R 20 , and wherein R 12 is selected from C 1-6 alkyl.

7. The compound, salt, or solvate of claim 1 , wherein R 7 is selected from C 1-6 alkyl, C 3-10 cycloalkyl, 3- to 10-membered heterocycloalkyl, and —N(R 12 )(R 13 ), wherein C 1-6 alkyl, C 3-10 cycloalkyl, and 3- to 10-membered heterocycloalkyl are optionally substituted with one, two, or three R 20 .

8. The compound, salt, or solvate of claim 1 , wherein R 7 is selected from

9. The compound, salt, or solvate of claim 1 , wherein R 7 is selected from

10. The compound, salt, or solvate of claim 1 , wherein R 8 is hydrogen.

11. The compound, salt, or solvate of claim 1 , wherein

is selected from phenyl and 5- to 7-membered heteroaryl, each of which is optionally substituted with one or more R 11 .

12. The compound, salt, or solvate of claim 1 , wherein

is selected from

13. The compound, salt, or solvate of claim 12 , wherein R 11 is independently selected from fluorine and —CH 3 .

14. The compound, salt, or solvate of claim 1 , wherein L 1 is C 1-3 haloalkylene.

15. The compound, salt, or solvate of claim 14 , wherein L 1 is selected from —CF 2 —, —CF 2 CH 2 —, and —CF 2 CH 2 CH 2 —.

16. The compound, salt, or solvate of claim 1 , wherein

is selected from absent, phenyl, and 4- to 8-membered heterocycle, wherein the phenyl and 4- to 8-membered heterocycle are optionally substituted with one or more R 11a .

17. The compound, salt, or solvate of claim 16 , wherein

is selected from azetidine, pyrrolidine, and piperidine, each of which is optionally substituted with one or more —CH 3 .

18. The compound, salt, or solvate of claim 1 , wherein L 2 is selected from C 6-15 alkylene, C 6-15 alkenylene, C 6-15 alkynylene, 6- to 15-membered heteroalkylene, and 6- to 15-membered heteroalkenylene, each of which is optionally substituted with one or more R 11b .

19. The compound, salt, or solvate of claim 1 , wherein L 2 is selected from C 5-10 alkylene, C 5-10 alkenylene, 5- to 10-membered heteroalkylene, and 5- to 10-membered heteroalkenylene, each of which is optionally substituted with one or more R 11b .

20. The compound, salt, or solvate of claim 18 , wherein the alkenylene and heteroalkenylene contain one carbon-carbon double bond.

21. The compound, salt, or solvate of claim 18 , wherein the heteroalkylene and heteroalkenylene comprise at least one oxygen or nitrogen atom.

22. The compound, salt, or solvate of claim 2 , wherein:

R 5 is hydrogen;

R 5b is —CH 3 ;

R 6 is selected from hydrogen and —OCH 3 ;

R 7 is selected from C 1-6 alkyl, C 3-10 carbocycle, 3- to 10-membered heterocycle, —N(R 12 )(R 13 ), —C(O)R 15 , —C(O)N(R 12 )(R 13 ), —S(O) 2 R 15 , and —SO 2 N(R 12 )(R 13 ), wherein C 1-6 alkyl, C 3-10 carbocycle, and 3- to 10-membered heterocycle are optionally substituted with one, two, or three R 20 ; and

R 8 is hydrogen.

23. The compound, salt, or solvate of claim 3 , wherein:

R 3 is hydrogen or —CH 3 ;

R 3b is —CH 3 ;

R 6 is selected from hydrogen and —OCH 3 ;

R 7 is selected from C 1-6 alkyl, C 3-10 carbocycle, 3- to 10-membered heterocycle, —N(R 12 )(R 13 ), —C(O)R 15 , —C(O)N(R 12 )(R 13 ), —S(O) 2 R 15 , and —SO 2 N(R 12 )(R 13 ), wherein C 1-6 alkyl, C 3-10 carbocycle, and 3- to 10-membered heterocycle are optionally substituted with one, two, or three R 20 ; and

R 8 is hydrogen.

24. The compound of claim 1 , wherein the compound is selected from

or a pharmaceutically acceptable salt or solvate thereof.

25. The compound of claim 1 having the structure

or a pharmaceutically acceptable salt or solvate thereof.

26. The compound of claim 1 having the structure

or a pharmaceutically acceptable salt or solvate thereof.

27. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt or solvate thereof, and a pharmaceutically acceptable excipient.

28. A method of inhibiting cell growth, comprising administering to a cell expressing SOS1 an effective amount of a compound of claim 1 , or a pharmaceutically acceptable salt or solvate thereof, thereby inhibiting growth of said cells.

29. The method of claim 28 , wherein the cell is a cancer cell.

30. The method of claim 28 , further comprising administering an additional agent to the cell.